Diversity-Oriented Synthesis of Coumarin-Fused Cyclopentanones via a Nucleophilic Phosphine Controlled Cascade Reaction

Abstract

A phosphine-promoted intermolecular annulation reaction of functionalized 3-benzoyl coumarin with alkynone has been disclosed. This reaction was found to be highly dependent on the nucleophilicity of the phosphine. Two classes of coumarin-fused cyclopentanones were selectively afforded in moderate to good yields with excellent diastereoselectivities under the mild reaction conditions.

Key words

diversity-oriented - cyclopentanone - phosphine - annulation

• References and Notes

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