Synthesis of Aryl Carboxylic Acids through Ambient Electro-oxidation of Arylacetylenes

Abstract

An efficient and environment-friendly synthesis of aryl carboxylic acids through the ambient electro-oxidation of the arylacetylenes is demonstrated. The reaction proceeds smoothly at certain applied potentials in a mixed solution of acetonitrile and water with potassium peroxymonosulfate (Oxone) as the additive. The isolated yields of the desired products are good up to 90%, and the reaction exhibits excellent functional-group tolerance. In this electrochemical system, transition metal catalysts, extra acids/bases, and high temperature are not required. This method may open up a pathway for the synthesis of carboxylic acids by the electrochemistry strategy.

Key words

arylacetylenes - aryl carboxylic acids - electrochemistry - oxidation - organic synthesis

Publication History

Received: 21 July 2023

Accepted after revision: 05 September 2023

Article published online:
18 October 2023

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