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CC BY-NC-ND 4.0 · Journal of Coloproctology 2022; 42(01): 063-067
DOI: 10.1055/s-0041-1739299
Original Article

Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma

Thiago da Silveira Manzione 
1   Surgery Department, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, SP, Brazil
2   Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brazil
,
Sidney Roberto Nadal 
2   Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brazil
,
Antônio José Gonçalves 
3   Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil
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Abstract

Objectives To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs).

Methods This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance < 5% was adopted for all statistical tests.

Results Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test.

Conclusion The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL.

Keywords

anal colposcopy - high-resolution anoscopy - anal high-grade squamous intraepithelial lesion - anal condyloma

Financial Support

None.




Publication History

Received: 16 July 2021

Accepted: 23 August 2021

Article published online:
10 December 2021

© 2021. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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