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CC BY 4.0 · Journal of Child Science 2021; 11(01): e327-e330
DOI: 10.1055/s-0041-1740466
Case Report

A Case of Postoperative SMART Syndrome in a Medulloblastoma Survivor

Cristian Cirjan
1   Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, Saint Louis, Missouri, United States
,
Ali Jamal
2   Department of Neurology, Cardinal Glennon Children's Hospital, Saint Louis University, Saint Louis, Missouri, United States
,
Philippe Mercier
3   Department of Neurosurgery, Cardinal Glennon Children's Hospital, Saint Louis University, Saint Louis, Missouri, United States
,
Rachel Berkovich
4   Department of Radiology, Cardinal Glennon Children's Hospital, Saint Louis University, Saint Louis, Missouri, United States
,
Pournima Navalkele 
5   Division of Hematology Oncology, Department of Pediatrics, Cardinal Glennon Children's Hospital, Saint Louis University, Saint Louis, Missouri, United States
› Author Affiliations Funding None.
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Abstract

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare neurological phenomenon characterized by reversible symptoms of headache, seizure, hemiparesis, and visual changes associated with a remote history of cranial irradiation. We describe a case of a medulloblastoma survivor, presenting with postoperative neurological deficits, along with neuroimaging findings and subsequent resolution of symptoms, highly suggestive of SMART syndrome. We have also reviewed the common epidemiological and diagnostic factors associated with this rare disease, as well as discussed pathophysiological mechanisms.

Keywords

radiation - migraine - stroke - SMART syndrome

Note

Written informed consent for publication of the clinical details was obtained from the legal guardian. A copy of the consent form is available for review by the editor of this journal.




Publication History

Received: 27 August 2021

Accepted: 02 November 2021

Article published online:
13 December 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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