Download PDF
Thorac Cardiovasc Surg 2023; 71(03): 197-205
DOI: 10.1055/s-0041-1740558
Original Basic Science

Dexmedetomidine Can Reduce the Level of Oxidative Stress and Serum miR-10a in Patients with Lung Cancer after Surgery

Yan Zhou
1   Department of Anesthesiology, The First People's Hospital of Jinan, Jinan, Shandong Province, China
,
Xia Dong
2   Department of Anesthesiology, Shizhong District People's Hospital of Jinan, Jinan, Shandong Province, China
,
Lei Zhang
3   Department of Operating Room, The First People's Hospital of Jinan, Jinan, Shandong Province, China
› Author Affiliations Funding Not applicable.
› Further Information
    Permissions and Reprints All articles of this category

Abstract

Objective Lung cancer is a primary cause of cancer death. This study assessed the action of dexmedetomidine (DEX) on oxidative stress (OS) and microRNA 10a (miR-10a) in patients with lung cancer.

Methods Patients were given 1 µg/kg DEX before anesthesia and control patients were given saline. The duration of intraoperative one-lung ventilation (OLV) and fluid intake were determined, and mean arterial pressure, heart rate and bispectral index were observed at the time of before anesthesia (T0), immediately after endotracheal intubation (T1), 1 hour after OLV (T2), and 10 minutes before the end of surgery (T3). The expressions and correlations of miR-10a, inflammation and OS levels in the serum were analyzed. The effects of DEX intervention and miR-10a level on pulmonary complications were analyzed.

Results Patients with DEX intervention had lower levels of inflammation and OS during perioperative period than the controls. DEX intervention reduced miR-10a levels in patients during perioperative period. miR-10a in serum of patients with DEX intervention after surgery was positively-correlated with the concentrations of malondialdehyde, and inflammatory factors, while negatively-correlated with superoxide dismutase. The total incidence of postoperative pulmonary complications after DEX intervention was lowered. Patients with high miR-10a expression had a higher cumulative incidence of pulmonary complications than those with low miR-10a expression.

Conclusion DEX can reduce postoperative OS and plasma miR-10a level in patients with lung cancer, and high expression of miR-10a predicts a high incidence of postoperative pulmonary complications.

Keywords

dexmedetomidine - lung cancer - miR-10a - inflammatory cytokines - oxidative stress - pulmonary complications - Pearson coefficients

Ethics Approval

This study was ratified by the Academic Ethics Committee of The First People's Hospital of Jinan. All patients in this study were fully informed of the purpose of this study and signed the informed consent before sampling.


Availability of Data and Materials

All the data generated or analyzed during this study are included in this published article.


Authors' Contributions

YZ contributed to the study concepts, study design, and guarantor of integrity of the entire study; XD contributed to the literature research; YZ, LZ contributed to the experimental studies and data acquisition; YZ, XD contributed to the manuscript preparation and LZ contributed to the manuscript editing and review. All authors read and approved the final manuscript.


Competing Interests

The authors declare that they have no competing interests.


Supplementary Material



Publication History

Received: 22 July 2021

Accepted: 19 October 2021

Article published online:
18 January 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Wang Y, Wu G, Li R. et al. Chinese medicine combined with EGFR-TKIs prolongs progression-free survival and overall survival of non-small cell lung cancer (NSCLC) patients harboring EGFR mutations, compared with the use of TKIs alone. Front Public Health 2021; 9: 677862
    CrossrefPubMedSearch in Google Scholar
  • 2 Xu T, Zhang X, Zhang S. et al. Imaging features and prognostic value of 18F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study. BMC Cancer 2020; 20 (01) 596
    CrossrefPubMedSearch in Google Scholar
  • 3 Li Y, Wang C, Bi M, Gao J, Zhang X, Tian H. Effect of dexmedetomidine on brain function and hemodynamics in patients undergoing lung cancer resection. Oncol Lett 2020; 20 (02) 1077-1082
    CrossrefPubMedSearch in Google Scholar
  • 4 Wang L, Sun J, Zhang X, Wang G. The effect of lidocaine on postoperative quality of recovery and lung protection of patients undergoing thoracoscopic radical resection of lung cancer. Drug Des Devel Ther 2021; 15: 1485-1493
    CrossrefPubMedSearch in Google Scholar
  • 5 Guo YB, Xu JD, Ji XX, Zhang JX, Liang JX, Zhou GB. [Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer]. Nan Fang Yi Ke Da Xue Xue Bao 2017; 37 (12) 1673-1677
    PubMedSearch in Google Scholar
  • 6 Ramaswamy SM, Weerink MAS, Struys MMRF, Nagaraj SB. Dexmedetomidine-induced deep sedation mimics non-rapid eye movement stage 3 sleep: large-scale validation using machine learning. Sleep (Basel) 2021; 44 (02) zsaa167
    CrossrefPubMedSearch in Google Scholar
  • 7 Jannu V, Dhorigol MG. Effect of Intraoperative dexmedetomidine on postoperative pain and pulmonary function following video-assisted thoracoscopic surgery. Anesth Essays Res 2020; 14 (01) 68-71
    CrossrefPubMedSearch in Google Scholar
  • 8 Xie Y, Jiang W, Zhao L, Wu Y, Xie H. Effect of dexmedetomidine on perioperative inflammation and lung protection in elderly patients undergoing radical resection of lung cancer. Int J Clin Exp Pathol 2020; 13 (10) 2544-2553
    PubMedSearch in Google Scholar
  • 9 Patel M, Wang Y, Bartom ET. et al. The ratio of toxic-to-nontoxic microRNAs predicts platinum sensitivity in ovarian cancer. Cancer Res 2021; 81 (15) 3985-4000
    CrossrefPubMedSearch in Google Scholar
  • 10 Bao M, Pan S, Yang W, Chen S, Shan Y, Shi H. Serum miR-10a-5p and miR-196a-5p as non-invasive biomarkers in non-small cell lung cancer. Int J Clin Exp Pathol 2018; 11 (02) 773-780
    PubMedSearch in Google Scholar
  • 11 Strycharz J, Wróblewski A, Zieleniak A. et al. Visceral adipose tissue of prediabetic and diabetic females shares a set of similarly upregulated microRNAs functionally annotated to inflammation, oxidative stress and insulin signaling. Antioxidants 2021; 10 (01) 101
    CrossrefPubMedSearch in Google Scholar
  • 12 Xiong Z, Jiang B, Li G. Downregulation of miR-10a inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion by targeting Syndecan-1. Int J Clin Exp Pathol 2020; 13 (10) 2502-2512
    PubMedSearch in Google Scholar
  • 13 Gao Y, Zhao H, Mu L. LncRNA-KAT7 negatively regulates miR-10a through an epigenetic pathway to participate in nonsmall cell lung cancer. Cancer Biother Radiopharm 2021; 36 (05) 441-445
    PubMedSearch in Google Scholar
  • 14 Travis WD, Brambilla E, Nicholson AG. et al; WHO Panel. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 2015; 10 (09) 1243-1260
    CrossrefPubMedSearch in Google Scholar
  • 15 Lee SH, Lee CY, Lee JG, Kim N, Lee HM, Oh YJ. Intraoperative dexmedetomidine improves the quality of recovery and postoperative pulmonary function in patients undergoing video-assisted thoracoscopic surgery: a CONSORT-prospective, randomized, controlled trial. Medicine (Baltimore) 2016; 95 (07) e2854
    CrossrefPubMedSearch in Google Scholar
  • 16 Xu D, Li W, Zhang T, Wang G. miR-10a overexpression aggravates renal ischemia-reperfusion injury associated with decreased PIK3CA expression. BMC Nephrol 2020; 21 (01) 248
    CrossrefPubMedSearch in Google Scholar
  • 17 Araki O, Matsumura Y, Inoue T. et al. Association of perioperative redox balance on long-term outcome in patients undergoing lung resection. Ann Thorac Cardiovasc Surg 2018; 24 (01) 13-18
    CrossrefPubMedSearch in Google Scholar
  • 18 Njock MS, Cheng HS, Dang LT. et al. Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood 2015; 125 (20) 3202-3212
    CrossrefPubMedSearch in Google Scholar
  • 19 Wang L, Tang S, Wang Z, Chen H, Rajcha SS, Qian J. The administration of dexmedetomidine changes microRNA expression profiling of rat hearts. Biomed Pharmacother 2019; 120: 109463
    CrossrefPubMedSearch in Google Scholar
  • 20 Chelazzi C, Villa G, Mancinelli P. et al. Perioperative levels of adiponectin and oxidative stress in patients undergoing laparoscopic abdominal surgery for cancer. Antiinflamm Antiallergy Agents Med Chem 2017; 16 (03) 168-174
    CrossrefPubMedSearch in Google Scholar
  • 21 Gunay S, Taskin A, Eser I, Yalcin S, Yalcin F. Oxidative stress and DNA damage due to one-lung ventilation. Ann Ital Chir 2018; 89: 24-29
    PubMedSearch in Google Scholar
  • 22 Kim S, Park SJ, Nam SB. et al. Pulmonary effects of dexmedetomidine infusion in thoracic aortic surgery under hypothermic circulatory arrest: a randomized placebo-controlled trial. Sci Rep 2021; 11 (01) 10975
    CrossrefPubMedSearch in Google Scholar
  • 23 Araújo AS, Nogueira IC, Gomes Neto A. et al. The impact of lung cancer resection surgery on fibrinogen and C-reactive protein and their relationship with patients outcomes: a prospective follow up study. Cancer Biomark 2016; 16 (01) 47-53
    CrossrefPubMedSearch in Google Scholar
  • 24 Wang Z, Shen Z, Wang H, Zhang L, Dong R. Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the PI3K/AKT signaling pathway. Oncol Lett 2020; 19 (02) 1151-1156
    PubMedSearch in Google Scholar
  • 25 Li YJ, Zhang DZ, Xi Y, Wu CA. Protective effect of dexmedetomidine on neuronal hypoxic injury through inhibition of miR-134. Hum Exp Toxicol 2021; 9603271211023784: 9603271211023784
    CrossrefPubMedSearch in Google Scholar
  • 26 Liu Y, Gu X, Liu Y. The effect of dexmedetomidine on biological behavior of osteosarcoma cells through miR-1307 expression. Am J Transl Res 2021; 13 (05) 4876-4883
    PubMedSearch in Google Scholar
  • 27 Zhu Y, Zhao H, Zhang W, Ma X, Liu Y. Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia–reperfusion by regulating miR–199a. Mol Med Rep 2021; 24 (02) 574
    CrossrefPubMedSearch in Google Scholar
  • 28 Poznyak AV, Bharadwaj D, Prasad G, Grechko AV, Sazonova MA, Orekhov AN. Anti-inflammatory therapy for atherosclerosis: focusing on cytokines. Int J Mol Sci 2021; 22 (13) 7061
    CrossrefPubMedSearch in Google Scholar
  • 29 Wei Y, Corbalán-Campos J, Gurung R. et al. Dicer in macrophages prevents atherosclerosis by promoting mitochondrial oxidative metabolism. Circulation 2018; 138 (18) 2007-2020
    CrossrefPubMedSearch in Google Scholar
  • 30 Çınar HU, Çelik B, Taşkın G, İnce Ö. Low thoracic muscle mass index on computed tomography predicts adverse outcomes following lobectomy via thoracotomy for lung cancer. Interact Cardiovasc Thorac Surg 2021; 33 (05) 712-720 .ivab150
    CrossrefPubMedSearch in Google Scholar
  • 31 Bai YX, Zhang JH, Zhao BC, Liu KX, Bai YW. Dexmedetomidine attenuates one-lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta-analysis. Clin Exp Pharmacol Physiol 2021; 48 (09) 1203-1214
    CrossrefPubMedSearch in Google Scholar