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CC BY 4.0 · Eur J Dent 2022; 16(04): 737-741
DOI: 10.1055/s-0041-1741012
Review Article

Future of Decellularized Dental Pulp Matrix in Regenerative Endodontics

Zohaib Khurshid 
1   Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Ahmed Jamil Ahmed Alnaim 
2   Dental Complex, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Ahmed Abdulhakim Ahmed Alhashim 
2   Dental Complex, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Eisha Imran
3   Department of Dental Materials, Islamabad Medical and Dental College, Islamabad, Pakistan
,
Necdet Adanir 
4   Department of Restorative Dentistry, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
› Author Affiliations Funding None.
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Abstract

With the advancements in tissue engineering, the repair and regeneration of oral/dental tissue are becoming possible and productive. Due to periodontal diseases, the tooth loses bone support resulting in tooth loss, but bone grafting stabilizes with new bone. It is seen that due to the progression of dental caries, pulp damage happens, and the vitality of the tooth is compromised. The current theme of dental pulp regeneration through biological and synthetic scaffolds, is becoming a potential therapy for pulp revitalization.

Keywords

tooth - dental pulp tissue - root canal treatment - decellularization - regenerative endodontics


Publication History

Article published online:
06 January 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Bakhtiar H, Pezeshki-Modaress M, Kiaipour Z. et al. Pulp ECM-derived macroporous scaffolds for stimulation of dental-pulp regeneration process. Dent Mater 2020; 36 (01) 76-87
    CrossrefPubMedSearch in Google Scholar
  • 2 Zhang X, Li H, Sun J. et al. Cell-derived micro-environment helps dental pulp stem cells promote dental pulp regeneration. Cell Prolif 2017; 50 (05) e12361
    CrossrefPubMedSearch in Google Scholar
  • 3 Smith AJ. Reflections and future visions for pulp biology research. J Endod 2020; 46 (9S): S42-S45
    CrossrefPubMedSearch in Google Scholar
  • 4 Paduano F, Marrelli M, White LJ, Shakesheff KM, Tatullo M. Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I. PLoS One 2016; 11 (02) e0148225
    CrossrefPubMedSearch in Google Scholar
  • 5 Simon S, Smith AJ. Regenerative endodontics. Br Dent J 2014; 216 (06) E13
    CrossrefPubMedSearch in Google Scholar
  • 6 Zafar MS, Khurshid Z, Almas K. Oral tissue engineering progress and challenges. Tissue Eng Regen Med 2015; 12 (06) 387-397
    CrossrefSearch in Google Scholar
  • 7 Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B. Regenerative endodontics: a comprehensive review. Int Endod J 2018; 51 (12) 1367-1388
    CrossrefPubMedSearch in Google Scholar
  • 8 Nygaard-Ostby B, Hjortdal O. Tissue formation in the root canal following pulp removal. Scand J Dent Res 1971; 79 (05) 333-349
    PubMedSearch in Google Scholar
  • 9 Alqahtani Q, Zaky SH, Patil A, Beniash E, Ray H, Sfeir C. Decellularized swine dental pulp tissue for regenerative root canal therapy. J Dent Res 2018; 97 (13) 1460-1467
    CrossrefPubMedSearch in Google Scholar
  • 10 Hu L, Gao Z, Xu J. et al. Decellularized swine dental pulp as a bioscaffold for pulp regeneration. BioMed Res Int 2017; 2017: 9342714
    CrossrefPubMedSearch in Google Scholar
  • 11 Bakhtiar H, Rajabi S, Pezeshki-Modaress M. et al. Optimizing methods for bovine dental pulp decellularization. J Endod 2021; 47 (01) 62-68
    CrossrefPubMedSearch in Google Scholar
  • 12 Lee DJ, Miguez P, Kwon J. et al. Decellularized pulp matrix as scaffold for mesenchymal stem cell mediated bone regeneration. J Tissue Eng 2020; 11: 2041731420981672
    CrossrefSearch in Google Scholar
  • 13 Li J, Rao Z, Zhao Y. et al. A decellularized matrix hydrogel derived from human dental pulp promotes dental pulp stem cell proliferation, migration, and induced multidirectional differentiation in vitro. J Endod 2020; 46 (10) 1438-1447.e5
    CrossrefPubMedSearch in Google Scholar
  • 14 Song JS, Takimoto K, Jeon M, Vadakekalam J, Ruparel NB, Diogenes A. Decellularized human dental pulp as a scaffold for regenerative endodontics. J Dent Res 2017; 96 (06) 640-646
    CrossrefPubMedSearch in Google Scholar
  • 15 Matoug-Elwerfelli M, Duggal MS, Nazzal H, Esteves F, Raïf E. A biocompatible decellularized pulp scaffold for regenerative endodontics. Int Endod J 2018; 51 (06) 663-673
    CrossrefPubMedSearch in Google Scholar
  • 16 Zhang W, Vazquez B, Oreadi D, Yelick PC. Decellularized tooth bud scaffolds for tooth regeneration. J Dent Res 2017; 96 (05) 516-523
    CrossrefPubMedSearch in Google Scholar