Pädiatrie up2date, Inhaltsverzeichnis Pädiatrie up2date 2016; 11(01): 15-30DOI: 10.1055/s-0042-100054 Entwicklung © Georg Thieme Verlag KG Stuttgart · New York Perinatale Programmierung Eva Nüsken , Felix Lechner , Kai-Dietrich Nüsken Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Siehe auch: Perinatale ProgrammierungFrauenheilkunde up2date 2016; 10(04): 335-350DOI: 10.1055/s-0042-111926 Volltext Referenzen Literatur 1 Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986; 1: 1077-1081 2 Barker DJ, Winter PD, Osmond C et al. Weight in infancy and death from ischaemic heart disease. Lancet 1989; 2: 577-580 3 Barker DJ. In utero programming of chronic disease. Clin Sci 1998; 95: 115-128 4 Barker DJ. Developmental origins of adult health and disease. J Epidemiol Community Health 2004; 58: 114-115 5 Kermack WO, McKendrick AG, McKinlay PL. Death-rates in Great Britain and Sweden. Some general regularities and their significance. Int J Epidemiol 2001; 30: 678-683 6 Dorner G. Problems and terminology of functional teratology. Acta Biol Med Ger 1975; 34: 1093-1095 7 Dorner G. Possible significance of prenatal and-or perinatal nutrition for the pathogenesis of obesity Acta Biol Med Ger. 1973; 30: K19-22 8 Dorner G, Grychtolik H. [Significance of early postnatal environmental influences for the late postnatal learning ability in children]. Acta Biol Med Ger 1973; 31: K53-56 9 Dorner G, Haller H, Leonhardt W. [Possible significance of pre- and or early postnatal nutrition in the pathogenesis of arteriosclerosis]. Acta Biol Med Ger 1973; 31: K31-35 10 Dorner G, Mohnike A. [Possible importance of pre- and-or early postnatal nutrition in the pathogenesis of diabetes mellitus]. Acta Biol Med Ger 1973; 31: K7-10 11 Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. NEJM 1976; 295: 349-353 12 Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?. Br J Prev Soc Med 1977; 31: 91-95 13 Freinkel N. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 1980; 29: 1023-1035 14 Barker DJ, Bull AR, Osmond C et al. Fetal and placental size and risk of hypertension in adult life. BMJ 1990; 301: 259-262 15 Hales CN, Barker DJ, Clark PM et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991; 303: 1019-1022 16 Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35: 595-601 17 Stanner SA, Bulmer K, Andres C et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 1997; 315: 1342-1348 18 Ravelli AC, van der Meulen JH, Michels RP et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998; 351: 173-177 19 Roseboom TJ, van der Meulen JH, Osmond C et al. Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45. Heart 2000; 84: 595-598 20 Claris O, Beltrand J, Levy-Marchal C. Consequences of intrauterine growth and early neonatal catch-up growth. Semin Perinatol 2010; 34: 207-210 21 Fewtrell MS, Doherty C, Cole TJ et al. Effects of size at birth, gestational age and early growth in preterm infants on glucose and insulin concentrations at 9–12 years. Diabetologia 2000; 43: 714-717 22 Lynch J, Smith GD. A life course approach to chronic disease epidemiology. Annu Rev Public Health 2005; 26: 1-35 23 Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004; 304: 108-110 24 Hinchliffe SA, Lynch MR, Sargent PH et al. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol 1992; 99: 296-301 25 Khulan B, Drake AJ. Glucocorticoids as mediators of developmental programming effects. Best Pract Res Clin Endocrinol Metab 2012; 26: 689-700 26 Reynolds RM, Walker BR, Syddall HE et al. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab 2001; 86: 245-250 27 Waterland RA, Lin JR, Smith CA et al. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet 2006; 15: 705-716 28 Heijmans BT, Tobi EW, Stein AD et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc National Academy of Sciences of the USA 2008; 105: 17046-17049 29 Tobi EW, Lumey LH, Talens RP et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Gen 2009; 18: 4046-4053 30 Burdge GC, Slater-Jefferies J, Torrens C et al. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr 2007; 97: 435-439 31 Delage B, Dashwood RH. Dietary manipulation of histone structure and function. Annu Rev Nutr 2008; 28: 347-366 32 Iorio MV, Piovan C, Croce CM. Interplay between microRNAs and the epigenetic machinery: an intricate network. Biochim Biophys Acta 2010; 1799: 694-701 33 Lee PA, Chernausek SD, Hokken-Koelega AC et al. International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24–October 1, 2001. Pediatrics 2003; 111: 1253-1261 34 Nusken KD, Schneider H, Plank C et al. Fetal programming of gene expression in growth-restricted rats depends on the cause of low birth weight. Endocrinol 2011; 152: 1327-1335 35 Baschat AA. Pathophysiology of fetal growth restriction: implications for diagnosis and surveillance. Obstet Gynecol Surv 2004; 59: 617-627 36 Gaillard R, Steegers EA, Tiemeier H et al. Placental vascular dysfunction, fetal and childhood growth, and cardiovascular development: the generation R study. Circulation 2013; 128: 2202-2210 37 Cosmi E, Visentin S, Fanelli T et al. Aortic intima media thickness in fetuses and children with intrauterine growth restriction. Obstet Gynecol 2009; 114: 1109-1114 38 Skilton MR, Evans N, Griffiths KA et al. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 2005; 365: 1484-1486 39 Zanardo V, Fanelli T, Weiner G et al. Intrauterine growth restriction is associated with persistent aortic wall thickening and glomerular proteinuria during infancy. Kidney Int 2011; 80: 119-123 40 Altin H, Karaarslan S, Karatas Z et al. Evaluation of cardiac functions in term small for gestational age newborns with mild growth retardation: a serial conventional and tissue Doppler imaging echocardiographic study. Early Hum Dev 2012; 88: 757-764 41 Crispi F, Bijnens B, Figueras F et al. Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation 2010; 121: 2427-2436 42 Sehgal A, Doctor T, Menahem S. Cardiac function and arterial indices in infants born small for gestational age: analysis by speckle tracking. Acta Paediatr 2014; 103: e49-54 43 Stampalija T, Casati D, Monasta L et al. Brain sparing effect in growth-restricted fetuses is associated with decreased cardiac acceleration and deceleration capacities: a case-control study. BJOG 2015 Sep 23 [Epub ahead of print] 44 Klebanoff MA, Secher NJ, Mednick BR et al. Maternal size at birth and the development of hypertension during pregnancy: a test of the Barker hypothesis. Arch Intern Med 1999; 159: 1607-1612 45 Konje JC, Bell SC, Morton JJ et al. Human fetal kidney morphometry during gestation and the relationship between weight, kidney morphometry and plasma active renin concentration at birth. Clin Sci 1996; 91: 169-175 46 Manalich R, Reyes L, Herrera M et al. Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 2000; 58: 770-773 47 Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 1996; 49: 1774-1777 48 Simonetti GD, Raio L, Surbek D et al. Salt sensitivity of children with low birth weight. Hypertension 2008; 52: 625-630 49 Hallan S, Euser AM, Irgens LM et al. Effect of intrauterine growth restriction on kidney function at young adult age: the Nord Trondelag Health (HUNT 2) Study. Am J Kidney Dis 2008; 51: 10-20 50 Lei X, Chen Y, Ye J et al. The optimal postnatal growth trajectory for term small for gestational age babies: a prospective cohort study. J Pediatr 2015; 167: 54-58 51 Singhal A, Cole TJ, Fewtrell M et al. Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure?. Circulation 2007; 115: 213-220 52 Giapros V, Papadimitriou P, Challa A et al. The effect of intrauterine growth retardation on renal function in the first two months of life. Nephrol Dial Transplant 2007; 22: 96-103 53 Henrichs J, Schenk JJ, Barendregt CS et al. Fetal growth from mid- to late pregnancy is associated with infant development: the Generation R Study. Dev Med Child Neurol 2010; 52: 644-651 54 van Batenburg-Eddes T, de Groot L, Steegers EA et al. Fetal programming of infant neuromotor development: the generation R study. Pediatr Res 2010; 67: 132-137 55 Levine TA, Grunau RE, McAuliffe FM et al. Early childhood neurodevelopment after intrauterine growth restriction: a systematic review. Pediatrics 2015; 135: 126-141 56 Murray E, Fernandes M, Fazel M et al. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG 2015; 122: 1062-1072 57 Geva R, Eshel R, Leitner Y et al. Neuropsychological outcome of children with intrauterine growth restriction: a 9-year prospective study. Pediatrics 2006; 118: 91-100 58 Leitner Y, Heldman D, Harel S et al. Deficits in spatial orientation of children with intrauterine growth retardation. Brain Res Bull 2005; 67: 13-18 59 Leitner Y, Fattal-Valevski A, Geva R et al. Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study. J Child Neurol 2007; 22: 580-587 60 Berle JO, Mykletun A, Daltveit AK et al. Outcomes in adulthood for children with foetal growth retardation. A linkage study from the Nord-Trondelag Health Study (HUNT) and the Medical Birth Registry of Norway. Acta Psychiatr Scand 2006; 113: 501-509 61 Rao MR, Hediger ML, Levine RJ et al. Effect of breastfeeding on cognitive development of infants born small for gestational age. Acta Paediatr 2002; 91: 267-274 62 Hediger ML, Overpeck MD, Kuczmarski RJ et al. Muscularity and fatness of infants and young children born small- or large-for-gestational-age. Pediatrics 1998; 102: E60 63 Hediger ML, Overpeck MD, McGlynn A et al. Growth and fatness at three to six years of age of children born small- or large-for-gestational age. Pediatrics 1999; 104: e33 64 Ibanez L, Lopez-Bermejo A, Suarez L et al. Visceral adiposity without overweight in children born small for gestational age. J Clin Endocrinol Metab 2008; 93: 2079-2083 65 Euser AM, Dekker FW, Hallan SI. Intrauterine growth restriction: no unifying risk factor for the metabolic syndrome in young adults. Eur J Cardiovasc Prev Rehab 2010; 17: 314-320 66 de Zegher F, Sebastiani G, Diaz M et al. Body composition and circulating high-molecular-weight adiponectin and IGF-I in infants born small for gestational age: breast- versus formula-feeding. Diabetes 2012; 61: 1969-1973 67 de Zegher F, Sebastiani G, Diaz M et al. Breast-feeding vs formula-feeding for infants born small-for-gestational-age: divergent effects on fat mass and on circulating IGF-I and high-molecular-weight adiponectin in late infancy. J Clin Endocrinol Metab 2013; 98: 1242-1247 68 Barker DJ, Godfrey KM, Fall C et al. Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ 1991; 303: 671-675 69 Kotecha SJ, Watkins WJ, Henderson AJ et al. The effect of birth weight on lung spirometry in white, school-aged children and adolescents born at term: a longitudinal population based observational cohort study. J Pediatr 2015; 167: 1163-1167 70 Nikolajev K, Heinonen K, Hakulinen A et al. Effects of intrauterine growth retardation and prematurity on spirometric flow values and lung volumes at school age in twin pairs. Pediatr Pulmonol 1998; 25: 367-370 71 Mu M, Ye S, Bai MJ et al. Birth weight and subsequent risk of asthma: a systematic review and meta-analysis. Heart Lung Circ 2014; 23: 511-519 72 Pirkola J, Pouta A, Bloigu A et al. Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus. Diabetes Care 2010; 33: 1115-1121 73 Perng W, Gillman MW, Mantzoros CS et al. A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood. Ann Epidemiol 2014; 24: 793-800e1 74 Kral JG, Biron S, Simard S et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 2006; 118: e1644-e1649 75 Guo L, Liu J, Ye R et al. Gestational Weight Gain and Overweight in Children Aged 3–6 Years. J Epidemiol 2015; 25: 536-543 76 Tie HT, Xia YY, Zeng YS et al. Risk of childhood overweight or obesity associated with excessive weight gain during pregnancy: a meta-analysis. Arch Gynecol Obstet 2014; 289: 247-257 77 Starling AP, Brinton JT, Glueck DH et al. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr 2015; 101: 302-309 78 Karachaliou M, Georgiou V, Roumeliotaki T et al. Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood. Am J Obstet Gynecol 2015; 212: 502 e1-14 79 Pugh SJ, Richardson GA, Hutcheon JA et al. Maternal Obesity and Excessive Gestational Weight Gain Are Associated with Components of Child Cognition. J Nutr 2015; 145: 2562-2569 80 Hinkle SN, Schieve LA, Stein AD et al. Associations between maternal prepregnancy body mass index and child neurodevelopment at 2 years of age. Int J Obes 2012; 36: 1312-1319 81 Jo H, Schieve LA, Sharma AJ et al. Maternal prepregnancy body mass index and child psychosocial development at 6 years of age. Pediatrics 2015; 135: e1198-e1209 82 Ou X, Thakali KM, Shankar K et al. Maternal adiposity negatively influences infant brain white matter development. Obesity 2015; 23: 1047-1054 83 Harpsoe MC, Basit S, Bager P et al. Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J Allergy Clin Immunol 2013; 131: 1033-1040 84 Leermakers ET, Sonnenschein-van der Voort AM, Gaillard R et al. Maternal weight, gestational weight gain and preschool wheezing: the Generation R Study. Eur Resp J 2013; 42: 1234-1243 85 Amir LH, Donath S. A systematic review of maternal obesity and breastfeeding intention, initiation and duration. BMC Pregnancy Childbirth 2007; 7: 9 86 Philipps LH, Santhakumaran S, Gale C et al. The diabetic pregnancy and offspring BMI in childhood: a systematic review and meta-analysis. Diabetologia 2011; 54: 1957-1966 87 Boney CM, Verma A, Tucker R et al. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: e290-e296 88 Landon MB, Rice MM, Varner MW et al. Mild gestational diabetes mellitus and long-term child health. Diabetes Care 2015; 38: 445-452 89 Stuart A, Amer-Wahlin I, Persson J et al. Long-term cardiovascular risk in relation to birth weight and exposure to maternal diabetes mellitus. Int J Cardiol 2013; 168: 2653-2657 90 Aceti A, Santhakumaran S, Logan KM et al. The diabetic pregnancy and offspring blood pressure in childhood: a systematic review and meta-analysis. Diabetologia 2012; 55: 3114-3127 91 Al-Biltagi M, Tolba OA, Rowisha MA et al. Speckle tracking and myocardial tissue imaging in infant of diabetic mother with gestational and pregestational diabetes. Pediatr Cardiol 2015; 36: 445-453 92 Russell NE, Higgins MF, Kinsley BF et al. Heart rate variability in neonates of type 1 diabetic pregnancy. Early Hum Dev 2016; 92: 51-55 93 Krishnaveni GV, Veena SR, Jones A et al. Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians. J Clin Endocrinol Metab 2015; 100: 986-993 94 Timmermans SH, Mommers M, Gubbels JS et al. Maternal smoking during pregnancy and childhood overweight and fat distribution: the KOALA Birth Cohort Study. Pediatr Obes 2014; 9: e14-25 95 Kooijman MN, Bakker H, Franco OH et al. Fetal Smoke Exposure and Kidney Outcomes in School-Aged Children. Am J Kidney Dis 2015; 66: 412-420 96 den Dekker HT, Sonnenschein-van der Voort AM, de Jongste JC et al. Tobacco Smoke Exposure, Airway Resistance, and Asthma in School-age Children: The Generation R Study. Chest 2015; 148: 607-617 97 Dolan CV, Geels L, Vink JM et al. Testing Causal Effects of Maternal Smoking During Pregnancy on Offspring’s Externalizing and Internalizing Behavior. Behav Genet 2015 Sep 1 [Epub ahead of print] 98 Moylan S, Gustavson K, Overland S et al. The impact of maternal smoking during pregnancy on depressive and anxiety behaviors in children: the Norwegian Mother and Child Cohort Study. BMC Med 2015; 13: 24 99 Williams GM, O'Callaghan M, Najman JM et al. Maternal cigarette smoking and child psychiatric morbidity: a longitudinal study. Pediatrics 1998; 102: e11 100 Stroud LR, Papandonatos GD, Rodriguez D et al. Maternal smoking during pregnancy and infant stress response: test of a prenatal programming hypothesis. Psychoneuroendocrinology 2014; 48: 29-40 101 Eiden RD, Molnar DS, Granger DA et al. Prenatal tobacco exposure and infant stress reactivity: role of child sex and maternal behavior. Dev Psychobiol 2015; 57: 212-225 102 Cohen G, Vella S, Jeffery H et al. Cardiovascular stress hyperreactivity in babies of smokers and in babies born preterm. Circulation 2008; 118: 1848-1853 103 Gollenberg AL, Addo OY, Zhang Z et al. In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in US girls approaching puberty. Horm Res Paediatr 2015; 83: 36-44 104 Mattsson K, Jonsson I, Malmqvist E et al. Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype. Eur J Epidemiol 2015; 30: 231-238 105 Mamun AA, O'Callaghan MJ, Williams GM et al. Maternal smoking during pregnancy predicts adult offspring cardiovascular risk factors – evidence from a community-based large birth cohort study. PloS one 2012; 7: e41106 106 Sevelsted A, Stokholm J, Bonnelykke K et al. Cesarean section and chronic immune disorders. Pediatrics 2015; 13 5: e92-98 107 Puff R, D'Orlando O, Heninger AK et al. Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section. Clin Immunol 2015; 160: 282-285 108 Poston L, Bell R, Croker H et al. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol 2015; 3: 767-777