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Planta Med 2016; 82(09/10): 857-871
DOI: 10.1055/s-0042-101763
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products

Ignacio Pérez-Victoria
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, Spain
,
Jesús Martín
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, Spain
,
Fernando Reyes
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, Spain
› Institutsangaben
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Publikationsverlauf

received 23. Oktober 2015
revised 22. Dezember 2015

accepted 05. Januar 2016

Publikationsdatum:
22. März 2016 (online)

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Erratum zu diesem Artikel:

Erratum for: Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural ProductsPlanta Med 2016; 82(09/10): E5-E5
DOI: 10.1055/s-0035-1568644

Abstract

Drug discovery from marine natural products has experienced a revival since the beginning of this century. To be successful in this field, rapid dereplication (identification of already known bioactive compounds) is essential in order to assess the chemical novelty of crude extracts and their fractions. Access to the appropriate state-of-the-art analytical instrumentation and to suitable databases is a fundamental requirement in such a task. A brief survey of the most robust LC/UV/MS- and NMR-based approaches employed for marine natural product dereplication is presented alongside a description of the procedures followed to achieve this goal in our research group.

Key words

marine natural products - dereplication - databases - microfractionation - LC/UV/MS - NMR - MS Gold - MEDINA-HRMS
 

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