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Pharmacopsychiatry 2016; 49(03): 97-106
DOI: 10.1055/s-0042-102457
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Azapirones for Attention Deficit Hyperactivity Disorder: A Systematic Review

Y. Matsui   *
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
S. Matsunaga   *
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
Y. Matsuda
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
T. Kishi
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
,
N. Iwata
1   Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 25. November 2015
revised 26. Januar 2016

accepted 27. Januar 2016

Publikationsdatum:
13. April 2016 (online)

Auch verfügbar auf
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Abstract

Introduction: No meta-analysis has evaluated azapirones (serotonin1A receptor partial agonists) as anxiolytics for attention deficit hyperactivity disorder (ADHD).

Methods: Randomized controlled trials (RCTs) and single-arm trials published before October 27, 2015 were retrieved from major healthcare databases and clinical trial registries. Relative risk and 95% confidence intervals were calculated.

Results: 5 RCTs (n=429) and 3 single-arm studies (n=70) were identified. 3 RCTs compared buspirone vs. methylphenidate in children/adolescents, one buspirone patches vs. placebo patches in children/adolescents, and one atomoxetine plus buspirone vs. atomoxetine vs. placebo in adults. The single-arm studies were buspirone trails in children/adolescents. All-cause discontinuation rates and adverse events did not differ between pooled buspirone and methylphenidate groups. No other meta-analyses of buspirone efficacy and safety vs. comparators were conducted due to insufficient data. 2 RCTs found no significant differences in parent and teacher ADHD-Rating Scale total scores between buspirone and methylphenidate, while one reported that methylphenidate improved parent and teacher ADHD-RS total scores vs. buspirone.

Discussion: It remains unclear whether buspirone use has benefit for ADHD patients and therefore further evidence is needed for better clinical use of buspirone in patients with ADHD.

Key words

azapirone - buspirone - attention deficit hyperactivity disorder - systematic review and meta-analysis - guidelines

* These authors contributed equally to this work.


 

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