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Planta Med 2016; 82(09/10): 872-876
DOI: 10.1055/s-0042-102885
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Zhenzhen Zhang
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Wenqiang Guo
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Xueqian He
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Qian Che
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Tianjiao Zhu
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Qianqun Gu
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
,
Dehai Li
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
› Author Affiliations
Further Information

Publication History

received 21 August 2015
revised 01 February 2016

accepted 03 February 2016

Publication Date:
22 March 2016 (online)

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Abstract

Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (1–2) and dimeric peniphenylanes C–G (3–7), together with four known biogenetically related compounds (8–11) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC50 = 9.3 µM).

Key words

Penicillium fellutanum - Trichocomaceae - 6-methylsaligenin - peniphenylanes - deep-sea-derived fungus - cytotoxic activity

Supporting Information

 

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