Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Zhenzhen Zhang; Wenqiang Guo; Xueqian He; Qian Che; Tianjiao Zhu; Qianqun Gu; Dehai Li

doi:10.1055/s-0042-102885

Planta Medica, Table of Contents

Planta Med 2016; 82(09/10): 872-876
DOI: 10.1055/s-0042-102885

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Zhenzhen Zhang

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Wenqiang Guo

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Xueqian He

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Qian Che

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Tianjiao Zhu

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Qianqun Gu

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

,

Dehai Li

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

› Author Affiliations

Abstract

Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (1–2) and dimeric peniphenylanes C–G (3–7), together with four known biogenetically related compounds (8–11) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC₅₀ = 9.3 µM).

Key words

Penicillium fellutanum - Trichocomaceae - 6-methylsaligenin - peniphenylanes - deep-sea-derived fungus - cytotoxic activity

Full Text

References

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