Mechanismen der Hautentzündung bei der Kontaktdermatitis

Zusammenfassung

Viele Chemikalien können eine allergische Kontaktdermatitis verursachen. Diese wird von T-Zellen vermittelt, die Hautzellen schädigen. Voraussetzung für die Aktivierung und Differenzierung kontaktallergenspezifischer T-Zellen ist die Aktivierung des angeborenen Immunsystems. Die daraus resultierende Hautentzündung ähnelt mechanistisch der angeborenen Immunantwort gegen Bakterien und Viren. Diese Übersicht beschreibt die Orchestrierung der Hautentzündung bei der Kontaktallergie auf molekularer und zellulärer Ebene.

Abstract

Many chemicals can cause allergic contact dermatitis. This skin disease is mediated by T cells which damage skin cells. A prerequisite for the activation and differentiation of contact allergen specific T cells is the activation of the innate immune system. The resulting skin inflammation mechanistically resembles the innate immune response to bacteria and viruses. This overview describes the orchestration of skin inflammation in allergic contact dermatitis at the molecular and cellular level.

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