Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications

Delphine Parrot; Nathalie Legrave; David Delmail; Martin Grube; Marcelino Suzuki; Sophie Tomasi

doi:10.1055/s-0042-105571

Planta Medica, Inhaltsverzeichnis

Planta Med 2016; 82(13): 1143-1152
DOI: 10.1055/s-0042-105571

Reviews

Georg Thieme Verlag KG Stuttgart · New York

Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications

Delphine Parrot^*

¹UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM “Produits naturels – Synthèses – Chimie Médicinale”, UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France

,

Nathalie Legrave^*

¹UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM “Produits naturels – Synthèses – Chimie Médicinale”, UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France

,

David Delmail

¹UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM “Produits naturels – Synthèses – Chimie Médicinale”, UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France

,

Martin Grube

³Institut für Pflanzenwissenschaften, Karl-Franzens-Universität, Graz, Austria

,

Marcelino Suzuki

²Sorbonne Universités, UPMC Univ. Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, F-66650 Banyuls/Mer, France

,

Sophie Tomasi

¹UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM “Produits naturels – Synthèses – Chimie Médicinale”, UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France

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Abstract

This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with a predominance of Alphaproteobacteria. Bacterial groups more relevant for secondary metabolite synthesis have also been revealed. This article summarizes studies reporting the abilities of these communities to produce metabolites with relevant bioactivities. The biotechnological interest of these bacteria for drug discovery is highlighted regarding the production of compounds with therapeutic potential. Special focus is given to the synthesis of the most promising compound, uncialamycin, a potent enediyne isolated from a Streptomyces sp. associated with Cladonia uncialis.

Key words

lichens - bacterial communities - chemodiversity - drug discovery - bioactive compounds - uncialamycin

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Referenzen

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