PDF herunterladen
Aktuelle Rheumatologie 2017; 42(05): 391-398
DOI: 10.1055/s-0042-105866
Übersichtsarbeit
Georg Thieme Verlag KG Stuttgart · New York

Kapillarmikroskopie

Nailfold Capillary Microscopy
O. Sander
1   Poliklinik und Funktionsbereich für Rheumatologie & Hiller Forschungszentrum Rheumatologie, Heinrich Heine-Universität Düsseldorf, Düsseldorf
,
C. Dechant
2   Rheuma-Einheit, Medizinische Klinik und Poliklinik IV, Universitätsklinikum München – Campus Innenstadt, München
,
C. Sunderkötter
3   Abteilung für translationale Dermatoinfektiologie, Westfälische Wilhelms-Universität Münster, Münster
,
P. Klein-Weigel
4   Klinik für Angiologie, HELIOS Klinikum Berlin-Buch, Berlin
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. Mai 2016 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Zusammenfassung

Die Kapillarmikroskopie spielt als bildgebendes Verfahren eine große Bedeutung in der Differenzialdiagnose mikrovaskulärer Pathologien der Haut. Bei Systemerkrankungen, insbesondere Kollagenosen werden hier spezifische Veränderungen gesehen. Zur Differenzierung eines Raynaud Syndroms ist sie unerlässlich. Diese interdisziplinär erstellte Arbeit bietet dem Leser eine aktuelle Übersicht der wichtigsten Anwendungsgebiete der Methode, Möglichkeiten, Grenzen der Kapillarmikroskopie und wagt einen Ausblick auf die zukünftige Entwicklung.

Abstract

Nailfold capillary microscopy is an imaging procedure of great diagnostic value in the differential diagnosis of microvascular skin pathologies. It enables the detection of specific changes in systemic diseases, especially connective tissue diseases, and is essential for the differentiation between primary and secondary Raynaud´s phenomenon. This interdisciplinary review provides a current overview of the most important applications of nailfold capillary microscopy as well as the chances and limitations of this procedure. Also it gives an outlook on the expected future development.

Schlüsselwörter

Kapillarmikroskopie - systemische Sklerose - Raynaud-Syndrom

Key words

nailfold capillary microscopy - systemic sclerosis - Raynaud’s phenomenon
 

  • Literatur

  • 1 Sander O, Sunderkötter C, Kötter I. et al. Kapillarmikroskopie Durchführung und Nomenklatur. Z Rheumatol 2010; 69: 253-262
    CrossrefPubMedGoogle Scholar
  • 2 Klein-Weigel P, Sunderkötter C, Sander O. Nailfold capillaroscopy microscopy – an interdisciplinary appraisal. VASA 2016 (accepted)
    PubMed
  • 3 Batticciotto A, Atzeni F, Foglia S. et al. Feet nailfold capillaroscopy is not useful to detect the typical scleroderma pattern. Clin Exp Rheumatol 2012; Mar-Apr 30 (Suppl. 71) S116-S117
    PubMedGoogle Scholar
  • 4 Lambova S, Hermann W, Müller-Ladner U. Capillaroscopic pattern at the toes of systemic sclerosis patients: does it „tell“ more than those of fingers?. J Clin Rheumatol 2011; 17: 311-314
    CrossrefPubMedGoogle Scholar
  • 5 Berks M, Tresadern P, Dinsdale G. et al. An automated system for detecting and measuring nailfold capillaries. Med Image Comput Comput Assist Interv 2014; 17: 658-654
    PubMedGoogle Scholar
  • 6 Sebastiani M, Manfredi A, Lo Monaco A. et al. Capillaroscopic Skin Ulcers Risk Index (CSURI) calculated with different videocapillaroscopy devices: how its predictive values change. Clin Exp Rheumatol 2013; 31 (Suppl. 76) 115-117
    PubMedGoogle Scholar
  • 7 Meli M, Gitzelmann G, Koppensteiner R. et al. Predictive value of nailfold capillaroscopy in patients with Raynaud’s phenomenon. Clin Rheumatol 2006; 25: 153-158
    CrossrefPubMedGoogle Scholar
  • 8 Sekiyama JY, Camargo CZ, Eduardo L. et al. Reliability of widefield nailfold capillaroscopy and video capillaroscopy in the assessment of patients with Raynaud’s phenomenon. Arthritis Care Res (Hoboken) 2013; 65: 1853-1861
    CrossrefPubMedGoogle Scholar
  • 9 Sebastiani M, Manfredi A, Vukatana G. et al. Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study. Ann Rheum Dis 2012; 71: 67-70
    CrossrefPubMedGoogle Scholar
  • 10 Sebastiani M, Manfredi A, Colaci M. et al. Capillaroscopic skin ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients. Arthritis Rheum 2009; 61: 688-694
    CrossrefPubMedGoogle Scholar
  • 11 Hoerth C, Kundi M, Katzenschlager R. et al. Qualitative and quantitative assessment of nailfold capillaries by capillaroscopy in healthy volunteers. Vasa 2012; 41: 19-2615
    CrossrefPubMedGoogle Scholar
  • 12 Sander O, Schroeder M, Ostendorf B. et al. Capillary microscopy – a cross-sectional study in the population. Arthritis Rheum 2010; 62: S671-S672
    PubMedGoogle Scholar
  • 13 Jung P, Trautinger F. Capillaroscopy of toes. J Dtsch Dermatol Ges 2013; 11: 855-866 Epub 2013 Jun 14
    PubMedGoogle Scholar
  • 14 Richter JG, Klein-Weigel P, Brinks R. et al. Geschlechtsspezifische Unterschiede und der Kapillarmikroskopie bei Gesunden und Patienten mit entzündlich rheumatischen Erkrankungen. Z Rheumatol 2014; 73: 615-622
    CrossrefPubMedGoogle Scholar
  • 15 Dolezalova P, Young SP, Bacon PA. et al. Nailfold capillary microscopy in health children and in childhood rheumatic diseases: a prospective single blind observational study. Ann Rheum Dis 2003; 62: 444-449
    CrossrefPubMedGoogle Scholar
  • 16 Terreri MT, Andrade LE, Puccinelli ML. et al. Nailfold capillaroscopy: normal findings in children and adolescents. Semin Arthritis Rheum 1999; 29: 36-42
    CrossrefPubMedGoogle Scholar
  • 17 Cony M, Klene-Boudard C, Fontan I. et al Periungual capillaroscopy patterns in normal children. Arch Fr Pediatr 1992; 49: 171-174
    PubMedGoogle Scholar
  • 18 Martino F, Agolini D, Aprigliano D. et al. Nailfold capillaroscopy in normal children between 0 and 16 years of age. Minerva Pediatr 1997; 49: 197-201
    PubMedGoogle Scholar
  • 19 Bollinger A, Fagrell B. Clinical capillaroscopy: A guide for its use in clinical research and practice. Toronto: Hogrefe & Huber; 1990
    Google Scholar
  • 20 Prete M, Fatone MC, Favoino E. et al. Raynaud’s phenomenon: from molecular pathogenesis to therapy. Autoimmun Rev 2014; 13: 655-667
    CrossrefPubMedGoogle Scholar
  • 21 Linnemann B, Erbe M. Raynaud’s phenomenon – assessment and differential diagnoses. Vasa 2015; 44: 166-177
    CrossrefPubMedGoogle Scholar
  • 22 Czirják L, Kiss CG, Lövei C. et al. Survey of Raynaud’s phenomenon and systemic sclerosis based on a representative study of 10,000 south Transdanubian Hungarian inhabitants. Clin Exp Rheumatol 2005; 23: 801-808
    PubMedGoogle Scholar
  • 23 Ziegler S, Brunner M, Eigenbauer E. et al. Long-term outcome of primary Raynaud’s phenomenon and its conversion to connective tissue disease: a 12-year retrospective patient analysis. Scand J Rheumatol 2003; 32: 343-347
    CrossrefPubMedGoogle Scholar
  • 24 Hirschl M, Hirschl K, Lenz M. et al. Transition from primary Raynaud’s phenomenon to secondary Raynaud’s phenomenon identified by diagnosis of an associated disease: results of ten years of prospective surveillance. Arthritis Rheum 2006; 54: 1974-1981
    CrossrefPubMedGoogle Scholar
  • 25 Jones GT, Herrick AL, Woodham SE. et al. Occurrence of Raynaud’s phenomenon in children ages 12–15 years: prevalence and association with other common symptoms. Arthritis Rheum 2003; 48: 3518-3521
    CrossrefPubMedGoogle Scholar
  • 26 Heslop J, Coggon D, Acheson ED. The prevalence of intermittent digital ischaemia (Raynaud’s phenomenon) in a general practice. J R Coll Gen Pract 1983; 33: 85-89
    PubMedGoogle Scholar
  • 27 Pavlov-Dolijanović S, Damjanov N, Ostojić P. et al. The prognostic value of nailfold capillary changes for the development of connective tissue disease in children and adolescents with primary raynaud phenomenon: a follow-up study of 250 patients. Pediatr Dermatol 2006; 23: 437-442
    CrossrefPubMedGoogle Scholar
  • 28 Nigrovic PA, Fuhlbrigge RC, Sundel RP. Raynaud’s phenomenon in children: a retrospective review of 123 patients. Pediatrics 2003; 111: 715-721
    CrossrefPubMedGoogle Scholar
  • 29 Heidrich H. Functional vascular diseases: Raynaud’s syndrome, acrocyanosis and erythromelalgia. Vasa 2010; 39: 33-41
    CrossrefPubMedGoogle Scholar
  • 30 Maricq H, Weinberger A, LeRoy E. Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud’s phenomenon. J Rheumatol 1982; 9: 289-291
    PubMedGoogle Scholar
  • 31 Carpentier P, Franco A., (Hrsg.). Atlas der Kapillaroskopie. Wiesbaden1983, Abbott GmbH.
    PubMed
  • 32 Cutolo M, Smith V. State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology?. Rheumatology (Oxford) 2013; 52: 1933-1940
    CrossrefPubMedGoogle Scholar
  • 33 Smith V, Pizzorni C, De Keyser F. et al. Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study. Ann Rheum Dis 2010; 69: 1092-1096
    CrossrefPubMedGoogle Scholar
  • 34 Sulli A, Soldano S, Pizzorni C. et al. Raynaud's phenomenon and plasma endothelin: correlations with capillaroscopic patterns in systemic sclerosis. J Rheumatol 2009; 36: 1235-1239
    CrossrefPubMedGoogle Scholar
  • 35 Smith V, Decuman S, Sulli A. et al. Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? A pilot study. Ann Rheum Dis 2012; 71: 1636-1639
    CrossrefPubMedGoogle Scholar
  • 36 Kayser C, Sekiyama JY, Próspero LC. et al. Nailfold capillaroscopy abnormalities as predictors of mortality in patients with systemic sclerosis. Clin Exp Rheumatol 2013; 31 (Suppl. 76) 103-108
    PubMedGoogle Scholar
  • 37 Avouac J, Vallucci M, Smith V. et al Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis. Arthritis Res Ther 2013; 15: R55
    CrossrefPubMedGoogle Scholar
  • 38 Aschwanden M, Daikeler T, Jaeger KA. et al. Rapid improvement of nailfold capillaroscopy after intense immunosuppression for systemic sclerosis and mixed connective tissue disease. Ann Rheum Dis 2008; 67: 1057-1059
    CrossrefPubMedGoogle Scholar
  • 39 Cutolo M, Zampogna G, Vremis L. et al. Longterm effects of endothelin receptor antagonism on microvascular damage evaluated by nailfold capillaroscopic analysis in systemic sclerosis. J Rheumatol 2013; 40: 40-45
    CrossrefPubMedGoogle Scholar
  • 40 Richter J, Klein-Weigel P. Acar et al. Kapillarmikroskopische Befunde bei Lupus erythematodes – Einflüsse der klinischen Manifestationen und des Geschlechts. Z Rheumatol S 2012; 71 Suppl.2 S21
    PubMedGoogle Scholar
  • 41 Lambova SN, Müller-Ladner U. Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn?. Rheumatol Int 2013; 33: 689-695
    CrossrefPubMedGoogle Scholar
  • 42 Aslanidis S, Pyrpasopoulou A, Doumas M. et al. Association of capillaroscopic microhaemorrhages with clinical and immunological antiphospholipid syndrome. Clin Exp Rheumatol 2011; 29: 307-309
    PubMedGoogle Scholar
  • 43 Leu AJ, Yanar A, Geiger M. et al. Dermatomyositis diagnostischer Wert der Kapillarmikroskopie. Schweiz Med Wochenschr 1991; 121: 363-367
    PubMedGoogle Scholar
  • 44 Mugii N, Hasegawa M, Matsushita T. et al. Association between nail-fold capillary findings and disease activity in dermatomyositis. Rheumatology (Oxford) 2011; 50: 1091-1098
    CrossrefPubMedGoogle Scholar
  • 45 Manfredi A, Sebastiani M, Cassone G. et al. Nailfold capillaroscopic changes in dermatomyositis and polymyositis. Clin Rheumatol 2015; 34: 279-284
    CrossrefPubMedGoogle Scholar
  • 46 Rossi D, Mansouri M, Baldovino S. et al. Nail fold videocapillaroscopy in mixed cryoglobulinaemia. Nephrol Dial Transplant 2004; 19: 2245-2249
    CrossrefPubMedGoogle Scholar
  • 47 Capobianco KG, Xavier RM, Bredemeier M. et al. Nailfold capillaroscopic findings in primary Sjögren’s syndrome: clinical and serological correlations. Clin Exp Rheumatol 2005; 23: 789-794
    PubMedGoogle Scholar
  • 48 Aguiar T, Furtado E, Dorigo D. et al. Nailfold videocapillaroscopy in primary Sjögren’s syndrome. Angiology 2006; 57: 593-599
    CrossrefPubMedGoogle Scholar
  • 49 Lambova SN, Müller-Ladner U. Capillaroscopic pattern in inflammatory arthritis. Microvasc Res 2012; 83: 318-322
    CrossrefPubMedGoogle Scholar
  • 50 Nash JW, Ross Jr P, Neil Crowson A. et al. The histopathologic spectrum of cryofibrinogenemia in four anatomic sites. Skin, lung, muscle, and kidney. Am J Clin Pathol 2003; 119: 114-122
    CrossrefPubMedGoogle Scholar
  • 51 Koenig M, Joyal F, Fritzler MJ. et al. Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed riteria for early systemic sclerosis. Arthritis Rheum 2008; 58: 3902-3912
    CrossrefPubMedGoogle Scholar
  • 52 Schlager O, Kiener HP, Stein L. et al. Associations of nailfold capillary abnormalities and immunological markers in early Raynaud’s phenomenon. Scand J Rheumatol 2014; 43: 226-233
    CrossrefPubMedGoogle Scholar
  • 53 Ingegnoli F, Boracchi P, Gualtierotti R. et al. Prognostic model based on nailfold capillaroscopy for identifying Raynaud’s phenomenon patients at high risk for the development of a scleroderma spectrum disorder: PRINCE (prognostic index for nailfold capillaroscopic examination). Arthritis Rheum 2008; 58: 2174-2182
    CrossrefPubMedGoogle Scholar
  • 54 Ingegnoli F, Boracchi P, Gualtierotti R. et al. Improving outcome prediction of systemic sclerosis from isolated Raynaud’s phenomenon: role of autoantibodies and nail-fold capillaroscopy. Rheumatology (Oxford) 2010; 49: 797-805
    CrossrefPubMedGoogle Scholar
  • 55 Avouac J, Fransen J, Walker UA et al. EUSTAR Group. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. Ann Rheum Dis 2011; 70: 476–481
    PubMed
  • 56 van den Hoogen F, Khanna D, Fransen J. et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 2013; 65: 2737-2747
    CrossrefPubMedGoogle Scholar
  • 57 Cutolo M, Pizzorni C, Sulli A. Identification of transition from primary Raynaud’s phenomenon to secondary Raynaud’s phenomenon by nailfold videocapillaroscopy: comment on the article by Hirschl et al. Arthritis Rheum 2007; 56: 2102-2103
    CrossrefPubMedGoogle Scholar
  • 58 McCann LJ, Pain CE. A Practical Approach to Juvenile Dermatomyositis and Juvenile Scleroderma. Indian J Pediatr 2015 Oct 22. [Epub ahead of print] PubMed PMID: 26489640
    PubMed
  • 59 Sebastiani M, Manfredi A, Cassone G. et al. Measuring microangiopathy abnormalities in systemic sclerosis patients: the role of capillaroscopy-based scoring models. Am J Med Sci 2014; 348: 331-336
    CrossrefPubMedGoogle Scholar
  • 60 Smith V, De Keyser F, Pizzorni C. et al. Nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions. Ann Rheum Dis 2011; 70: 180-183
    CrossrefPubMedGoogle Scholar
  • 61 Wildt M, Wuttge DM, Hesselstrand R. et al. Assessment of capillary density in systemic sclerosis with three different capillaroscopic methods. Clin Exp Rheumatol 2012; 30 (Suppl. 71) S50-S54
    PubMedGoogle Scholar
  • 62 Berks M, Tresadern P, Dinsdale G. et al. An automated system for detecting and measuring nailfold capillaries. Med Image Comput Comput Assist Interv 2014; 17: 658-665
    PubMedGoogle Scholar