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DOI: 10.1055/s-0042-112031
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd
Publication History
received 16 March 2016
revised 26 June 2016
accepted 05 July 2016
Publication Date:
21 July 2016 (online)
![](https://www.thieme-connect.de/media/plantamedica/20170304/lookinside/thumbnails/10-1055-s-0042-112031_pma0246-1.jpg)
Abstract
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 µM, IC50 = 34.7 µM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 µM, IC50 = 6.4 µM pentamidine, 29–13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 µM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
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