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Planta Med 2017; 83(01/02): 158-163
DOI: 10.1055/s-0042-112998
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Butyrolactones and Diketopiperazines from Marine Microbes: Inhibition Effects on Dengue Virus Type 2 Replication

Chun-Kuang Lin
1   Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan
,
Yu-Ting Wang
2   Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
,
Er-Mao Hung
2   Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
,
Yu-Liang Yang
1   Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan
3   Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
4   Graduate Institute of Natural products, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Jin-Ching Lee
5   Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Jyh-horng Sheu
1   Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan
2   Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
4   Graduate Institute of Natural products, Kaohsiung Medical University, Kaohsiung, Taiwan
6   Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan
,
Chih-Chuang Liaw
1   Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan
2   Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
4   Graduate Institute of Natural products, Kaohsiung Medical University, Kaohsiung, Taiwan
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Weitere Informationen

Publikationsverlauf

received 18. November 2015
revised 29. Juni 2016

accepted 13. Juli 2016

Publikationsdatum:
19. August 2016 (online)

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Abstract

Two new compounds, 4S,10R-dihydroxy-11-methyl-dodec-2-en-1,4-olide (1) (butyrolactone-type) and cyclo-(4-trans-6-dihydroxy-proline-D-leucine) (2) (diketopiperazine-type), as well as one known 4S,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (3) and three known diketopiperazines, cyclo-(L-proline-L-leucine) (4), cyclo-(4-trans-hydroxy-L-proline-L-leucine) (5), and cyclo-(4-trans-hydroxy-L-proline-L-phenylalanine) (6), were isolated from the ethyl acetate extracts of Streptomyces gougerotii GT and Microbulbifer variabilis C-03. Compounds 3, 4, 5, and 6 exhibited a significant reduction effect on dengue virus type 2 replication with EC50 values of 21.2, 16.5, 12.3, and 11.2 µM, respectively.

Key words

Streptomyces gougerotii - Streptomycetaceae - Microbulbifer variabilis - Alteromonadaceae - Butyrolactone - diketopiperazine - dengue virus type 2 replication

Supporting Information

 

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