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Drug Res (Stuttg) 2017; 67(02): 127-130
DOI: 10.1055/s-0042-113458
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

Antitumour and Apoptotic Effects of a Plant Extract Mixture Containing Rhus verniciflua and Other Herbs in Human Leukaemia Cells

Kohei Suruga
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Wataru Hiruma
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Kazunari Kadokura
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Tsuyoshi Tomita
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Ayaka Miyata
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Yoshihiro Sekino
1   International Operation Department (FM Center for R & D), Kibun Foods Inc., Tokyo, Japan
,
Masahiko Kimura
2   Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
,
Nobuo Yamaguchi
3   Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan
4   Department of Fundamental Research for CAM, Kanazawa Medical University, Ishikawa, Japan
,
Tae Murai
5   Kinder-Care Veterinary Clinic, Tochigi, Japan
,
Yasuhiro Komatsu
6   Kitasato Institution for Life Science, Kitasato University, Tokyo, Japan
7   Sun R & D Institute for Natural Medicines Co. Inc., Tokyo, Japan
,
Nobufumi Ono
2   Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
› Author Affiliations
Further Information

Publication History

received 04 April 2016

accepted 22 July 2016

Publication Date:
14 September 2016 (online)

Also available at
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Abstract

The apoptotic effects of a novel antitumour agent (Rv-PEM01) prepared from 6 kinds of herbs, including Rhus verniciflua were investigated using flow cytometry and western blot analysis. Rv-PEM01 induced apoptosis but not necrosis in MOLT-3, KG-1, and K562 human leukaemia cell lines. Further, Rv-PEM01-treated cells showed significantly upregulated expression of caspase-3 and 9 and cleaved caspase-3 and 9 compared to the control cells. Taken together, the results suggest that Rv-PEM01 induced apoptosis via the mitochondrial-mediated pathway, and is a potential natural anticancer agent and/or a functional food material.

Key words

anticancer drugs - apoptosis - cell proliferation and malignancy
 

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