Allgemein- und Viszeralchirurgie up2date, Table of Contents Allgemein- und Viszeralchirurgie up2date 2016; 10(06): 433-447DOI: 10.1055/s-0042-115984 Interventionelle und diagnostische Endoskopie Georg Thieme Verlag KG Stuttgart · New York Palliative Optionen bei Klatskin-Tumoren S. Belle II. Medizinische Klinik, Universitätsmedizin Mannheim › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Die Gallengangskarzinome sind eine seltene Entität, aber eine besondere klinische Herausforderung. Eine Heilung ist nur chirurgisch möglich. Bei der initialen Präsentation der Patienten können ⅔ nicht mehr kurativ operiert werden. Aufgrund der Lage des Tumors weisen insbesondere extrahepatische Gallengangskarzinome auch schon als kleine Tumoren eine relevante klinische Symptomatik auf und stellen hohe Anforderungen an die Therapie der Erkrankung. Full Text References Literatur 1 Vienne A, Hobeika E, Gouya H et al. Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment. Gastrointest Endosc 2010; 72: 728-735 2 Walter D, van Boeckel PGA, Groenen MJ et al. Cost efficacy of metal stents for palliation of extrahepatic bile duct obstruction in a randomized controlled trial. Gastroenterology 2015; 149: 130-138 3 Hara K, Yamao K, Mizuno N et al. Endoscopic ultrasonography-guided biliary drainage: Who, when, which, and how?. World J Gastroenterol 2016; 22: 1297-1298 4 Paik WH, Park YS, Hwang JH et al. Palliative treatment with self-expandable metallic stents in patients with advanced type III or IV hilar cholangiocarcinoma: a percutaneous versus endoscopic approach. Gastrointest Endosc 2009; 69: 55-62 5 Wiggers J, Koerkamp B, Coelen R et al. Preoperative biliary drainage in perihilar cholangiocarcinoma: identifying patients who require percutaneous drainage after failed endoscopic drainage. Endoscopy 2015; 18: 1-8 6 Ortner MA, Dorta G. Technology insight: photodynamic therapy for cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 459-467 7 Ortner ME, Caca K, Berr F et al. Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology 2003; 125: 1355-1363 8 Zoepf T, Jakobs R, Arnold JC et al. Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy. Am J Gastroenterol 2005; 100: 2426-2430 9 Lu Y, Liu L, Wu JC et al. Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis. Clin Res Hepatol Gastroenterol 2015; 39: 718-724 10 Pahernik SA, Dellian M, Berr F et al. Distribution and pharmacokinetics of Photofrin in human bile duct cancer. J Photochem Photobiol B 1998; 47: 58-62 11 Wiedmann M, Caca K, Berr F et al. Neoadjuvant photodynamic therapy as a new approach to treating hilar cholangiocarcinoma. Cancer 2003; 97: 2783-2790 12 Dougherty TJ, Gomer CJ, Henderson BW et al. Photodynamic therapy. J Natl Cancer Inst 1998; 90: 889-905 13 Gollnick SO, Vaughan L, Henderson BW. Generation of effective antitumor vaccines using photodynamic therapy. Cancer Res 2002; 62: 1604-1608 14 Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer 2003; 3: 380-387 15 Dolak W, Schreiber F, Schwaighofer H et al. Endoscopic radiofrequency ablation for malignant biliary obstruction: a nationwide retrospective study of 84 consecutive applications. Surg Endosc 2014; 28: 854-860 16 Kallis Y, Phillips N, Steel A et al. Analysis of endoscopic radiofrequency ablation of biliary malignant strictures in pancreatic cancer suggests potential survival benefit. Dig Dis Sci 2015; 60: 3449-3455 17 Sharaiha RZ, Natov N, Glockenberg KS et al. Comparison of metal stenting with radiofrequency ablation versus stenting alone for treating malignant biliary strictures: Is there an added benefit?. Dig Dis Sci 2014; 59: 3099-3102 18 Eckel F, Schmid RM. Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 2007; 96: 896-902 19 Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 2010; 362: 1273-1281 20 Okusaka T, Nakachi K, Fukutomi A et al. Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan. Br J Cancer 2010; 103: 469-474 21 Witzigmann H, Berr F, Ringel U et al. Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma. Ann Surg 2006; 244: 230-239 22 Matull WR, Dhar DK, Ayaru L et al. R0 but not R1/R2 resection is associated with better survival than palliative photodynamic therapy in biliary tract cancer. Liver Int 2010; 31: 99-107 23 Park DH, Lee SS, Park SE et al. Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma. Eur J Cancer 2014; 50: 1259-1268 24 Wentrup R, Winkelmann N, Mitroshkin A et al. Photodynamic therapy plus chemotherapy compared with photodynamic therapy alone in hilar nonresectable cholangiocarcinoma. Gut Liver 2016; 10: 470-475 25 Chen MH, Liang PC, Chang KC et al. Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning. Biomed Eng Online 2014; 13: 118
