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Horm Metab Res 2016; 48(11): 779-784
DOI: 10.1055/s-0042-117636
Review
© Georg Thieme Verlag KG Stuttgart · New York

Normal and Delayed Fracture Healing: Symphony and Cacophony

S. Jha
1   National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
,
J. E. Blau
2   Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD, USA
,
T. Bhattacharyya
1   National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
› Author Affiliations
Further Information

Publication History

received 08 July 2016

accepted 08 September 2016

Publication Date:
11 October 2016 (online)

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Abstract

The incidence of any fracture in the US is estimated to be 2 704 fractures per 100,000 person-years. Approximately 10 percent of these fractures develop complications of healing. The processes that occur during fracture healing mimic the processes that take place in the growth plate during development. The study of fracture healing represents a window to enhance our understanding of the processes of growth and development of bones and its reparative biology. This review is aimed for clinicians evaluating non-unions as an overview of different factors that inhibit fracture healing.

Key words

skeletal injury - bone repair - callus formation
 

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