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Planta Medica International Open 2016; 3(03): e60-e62
DOI: 10.1055/s-0042-118778
Letter
Georg Thieme Verlag KG Stuttgart · New York

Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12

Jiro Takito   *
1   Department of Anti-Dementia Functional Food Development, Graduate School of Engineering, Tohoku University, Aoba, Aramaki, Sendai, Japan
2   Department of Oral Anatomy and Developmental Biology, School of Dentistry, Showa University, Hatanodai, Shinagawa, Tokyo, Japan
,
Masaki Ota
3   Research Center of Supercritical Fluid Technology, Tohoku University, Aoba-ku, Aramaki, Sendai, Japan
,
Chisato Oba
3   Research Center of Supercritical Fluid Technology, Tohoku University, Aoba-ku, Aramaki, Sendai, Japan
,
Hironori Fujiwara
1   Department of Anti-Dementia Functional Food Development, Graduate School of Engineering, Tohoku University, Aoba, Aramaki, Sendai, Japan
,
Kiyoshi Murata
4   Japan Royal Jelly (JRJ) Co. Ltd., R&D Center, Ganbara, Kami-machi, Kami-gun, Miyagi, Japan
,
Kikuji Yamaguchi   *
1   Department of Anti-Dementia Functional Food Development, Graduate School of Engineering, Tohoku University, Aoba, Aramaki, Sendai, Japan
5   Japan Royal Jelly (JRJ) Co. Ltd., Kyobashi, Chuo-ku, Tokyo, Japan
,
Nobuyuki Uozumi
6   Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aoba, Aramaki, Sendai, Japan
,
Masanori Nakamura
2   Department of Oral Anatomy and Developmental Biology, School of Dentistry, Showa University, Hatanodai, Shinagawa, Tokyo, Japan
,
Hiroshi Inomata
3   Research Center of Supercritical Fluid Technology, Tohoku University, Aoba-ku, Aramaki, Sendai, Japan
,
Yasushi Ohizumi   *
1   Department of Anti-Dementia Functional Food Development, Graduate School of Engineering, Tohoku University, Aoba, Aramaki, Sendai, Japan
7   Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
8   Kansei Fukushi Research Center, Tohoku Fukushi University, Kunimi, Aoba-ku, Sendai, Japan
› Author Affiliations
Further Information

Publication History

received 10 February 2016
revised 30 July 2016

accepted 08 August 2016

Publication Date:
17 January 2017 (online)

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Abstract

Prevention and treatment of Alzheimerʼs disease are urgent problems for elderly people in developed countries. To seek useful compounds that treat, delay the onset, or prevent the development of Alzheimerʼs disease, we screened natural resources using the cyclic AMP response element-dependent transcription in the PC12 cell line. We previously found that honey bee royal jelly stimulates the cyclic AMP response element-dependent transcription activity in PC12 cells. Here, we report that R-limonene, a monoterpene, enhanced the royal jelly-induced cyclic AMP response element-dependent transcription activity, whereas R-limonene showed no effect in absence of royal jelly. The enhancement was inhibited by ZM241385, an antagonist for adenosine A2 A receptor. R-limonene also enhanced the cyclic AMP response element-dependent transcription activity activated by adenosine and AMP. Thus, R-limonene represents a novel type of modulator that enhances the CRE-dependent transcription via adenosine A2 A receptor pathway.

Key words

adenosine receptor - CRE-dependent transcription - limonene - memory - royal jelly

* These authors contributed equally to this work.


Supporting Information

 

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