Planta Medica International Open, Inhaltsverzeichnis Planta Medica International Open 2017; 4(01): e1-e7DOI: 10.1055/s-0042-121608 Letter Georg Thieme Verlag KG Stuttgart · New York Inhibition of Degranulation of RBL-2H3 Cells by Extracts and Compounds from Armillaria ostoyae Simon Merdivan 1 Institute of Pharmacy, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany , Kristina Jenett-Siems 2 Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany , Karsten Siems 3 AnalytiCon Discovery GmbH, Potsdam, Germany , Timo Niedermeyer 4 Interfaculty Institute of Microbiology and Infection Medicine, Eberhard Karls University Tübingen, Tübingen, Germany , Michael J. Solis 5 Institute of Botany and Landscape Ecology, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany 6 Department of Natural Sciences, College of Science and Information Technology, Ateneo de Zamboanga University, Zamboanga City, Philippines , Martin Unterseher 5 Institute of Botany and Landscape Ecology, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany , Ulrike Lindequist 1 Institute of Pharmacy, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany › Institutsangaben Artikel empfehlen Abstract Abstract Armillaria ostoyae (Romagn.) Herink is an edible honey mushroom from the family Physalacriaceae (Agaricales, Basidiomycota). Dichloromethane extracts of mushroom mycelium and fruiting bodies exhibited a significant degranulation inhibiting effect on RBL-2H3 cells using noncytotoxic concentrations. Bioactivity-guided fractionation of the mycelial dichloromethane extract led to the isolation of sesquiterpen aryl esters. Methyl linoleate could also be isolated. These substances were obtained from A. ostoyae for the first time, with one compound representing an undescribed natural product. Purified compounds melleolide H and J inhibited degranulation significantly. A. ostoyae could be a candidate for support of allergy treatments. Key words Key words Armillaria ostoyae - Physalacriaceae - RBL-2H3 - sesquiterpene aryl esters - β-hexosaminidase assay - melleolide - cytotoxicity Volltext Referenzen References 1 Romagnesi H. Observations on Armillaria. Bull Trimest Soc Mycol Fr 1970; 86: 257-265 2 Dobbertin M, Baltensweiler A, Rigling D. Tree mortality in an unmanaged mountain pine (Pinus mugo var. uncinata) stand in the Swiss National Park impacted by root rot fungi. For Ecol Manage 2001; 145: 79-89 3 Cleary MR, van der Kamp BJ, Morrison DJ. Effects of wounding and fungal infection with Armillaria ostoyae in three conifer species. II. Host response to the pathogen. 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