Die CE-MARC-Studien: Vom Saulus zum Paulus oder „Manchmal kommt es anders als man denkt“

Zusammenfassung

Die CE-MARC-Studie und die CE-MARC-2-Studie sind direkte bzw. indirekte Vergleichsstudien zwischen Myokard-SPECT-Untersuchungen und kardialer MRT. Nachdem die kardiale MRT die Myokard-SPECT in der Single-Center CE-MARC-Studie bez. Sensitivität und negativem prädiktiven Wert signifikant übertroffen hat, erfolgte die CE-MARC-2 Studie in einem multizentrischen Setting mit wesentlich besserer Myokard-SPECT-Technik als in der Initialstudie. Die Vorteile der kardialen MRT gegenüber der Myokard-SPECT aus der initialen Studie waren in der besser designten Folgestudie nicht mehr nachweisbar. Im Gegensatz zur ersten Studie schnitt die Myokard-SPECT in der CE-MARC-2 Studie in fast allen Parametern besser als die kardiale MRT ab, trotz ausschließlichem Einsatz von 3 Tesla MRT-Scannern.

Abstract

CE-MARC and CE-MARC 2 are high-ranking published studies comparing myocardial SPECT and cardiac MRI directly and indirectly resp. CE-MARC showed a superiority of cardiac MRI in comparison to myocardial SPECT concerning sensitivity and negative predictive value in a single center study design. The successive CE-MARC 2 study was designed and performed in a multi-center setting and with improved techniques concerning myocardial SPECT in comparison to the initial study. Advantages for cardiac MRI over SPECT shown in the initial CE-MARC study could not be obtained any more in the current CE-MARC-2 trial. Despite of using high-end 3 Tesla MRI scanner the performance of myocardial SPECT in the current CE-MARC-2 study was considerably better in comparison to cardiac MRI in almost all parameters.

Schlüsselwörter

CE-MARC - cardiale MRT - Myokard-SPECT

Key words

CE-MARC - MRI - SPECT

• Literatur

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