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DOI: 10.1055/s-0042-123788
Vitamin D in Klinik und Praxis
Vitamin D in Clinic and PracticePublication History
Publication Date:
21 April 2017 (online)
Abstract
Vitamin D is unique among the vitamins, since its major source is skin synthesis by solar UVB exposure, whereas dietary intake plays only a minor role. In the general population, cutaneous vitamin D synthesis is clearly below the recommended amount. Dietary vitamin D does not fill this gap. Severe vitamin D deficiency results in rickets in infants and osteomalacia in adults. In the absence of endogenous vitamin D synthesis (e. g. during winter), oral supplements should ensure adequate daily vitamin D intake, where appropriate. This is particularly true for nursing home residents, non-European migrants and dark-skinned people.
Vitamin-D-Mangel und seine Konsequenzen – seit Jahren schon ein sehr präsentes Thema. Nicht zu Unrecht: In der Allgemeinbevölkerung verfehlt die kutane Vitamin-D-Synthese besonders im Winter deutlich die Zufuhrempfehlung. Klar ist, aufgrund der vielfältigen Wirkungen wird Vitamin D auch in Zukunft weiter an Bedeutung gewinnen. Der CME-Beitrag hilft Ihnen, in der Informationsflut die Relevanz des Themas für Klinik und Praxis zu bewahren.
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Literatur
- 1 Holick MF. Bioavailability of vitamin D and its metabolites in black and white adults. N Engl J Med 2013; 369: 2047-2048
- 2 Wang TJ. Zhang F. Richards JB. et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010; 376: 180-188
- 3 Schlingmann KP. Kaufmann M. Weber S. et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med 2011; 365: 410-421
- 4 Hintzpeter B. Scheidt-Nave C. Müller MJ. et al. Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr 2008; 138: 1482-1490
- 5 Hintzpeter B. Mensink GB. Thierfelder W. et al. Vitamin D status and health correlates among German adults. Eur J Clin Nutr 2008; 62: 1079-1089
- 6 Zittermann A. von Helden R. Grant W. et al. An estimate of the survival benefit of improving vitamin D status in the adult german population. Dermatoendocrinol 2009; 1: 300-306
- 7 Kramer J. Diehl A. Lehnert H. Epidemiologische Untersuchung zur Häufigkeit eines Vitamin-D-Mangels in Nordeutschland. Dtsch Med Wochenschr 2014; 139: 470-475
- 8 Schilling S. Epidemic vitamin D deficiency among patients in an elderly care rehabilitation facility. Dtsch Arztebl Int 2012; 109: 33-38
- 9 Pilz S. Dobnig H. Tomaschitz A. et al. Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents. J Clin Endocrinol Metab 2012; 97: 653-657
- 10 Mahlstedt J. Moka D. Vitamin D-Mangel und sekundärer Hyperparathyreoidismus im Ruhrgebiet (Nordrhein-Westfalen/Deutschland). Nuklearmediziner 2009; 32: 1-8
- 11 Spiro A. Buttriss JL. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull 2014; 39: 322-350
- 12 Engelsen O. The relationship between ultraviolet radiation exposure and vitamin D status. Nutrients 2010; 2: 482-495
- 13 Wortsman J. Matsuoka LY. Chen TC. et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690-693
- 14 Rock CL. Emond JA. Flatt SW. et al. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity (Silver Spring) 2012; 20: 2296-2301
- 15 Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung. Referenzwerte für die Nährstoffzufuhr. 1. Aufl. Neustadt an derWeinstraße: Neuer Umschau Buchverlag; 2013. (5. korrigierter Nachdruck)
- 16 Ross AC. Taylor CL. Yaktine AL. Del Valle HB. Hrsg. Institute of Medicine of the National Academies, Food and Nutrition Board. Dietary Reference Intakes Calcium Vitamin D. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Washington, D.C: The National Academies Press; 2010
- 17 Holick MF. Binkley NC. Bischoff-Ferrari HA. et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930
- 18 European Food Safety Authority. Scientific Opinion on the Tolerable Upper Intake Level of vitamin D. EFSA Journal 2012; 10: 2813
- 19 Godar DE. Pope SJ. Grant WB. et al. Solar UV doses of adult Americans and vitamin D(3) production. Dermatoendocrinol 2011; 3: 243-250
- 20 Max Rubner-Institut, Bundesforschungsinstitut für Ernährung und Lebensmittel. Nationale Verzehrstudie II, Ergebnisbericht Teil 2. 2008. Im Internet: http://www.was-esse-ich.de/uploads/media/NVSII_Abschlussbericht_Teil_2.pdf (Stand: 17.11.2015)
- 21 Pérez-López FR. Pasupuleti V. Mezones-Holguin E. et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103: 1278-1288.e4
- 22 Elder CJ. Bishop NJ. Rickets. Lancet 2014; 383: 1665-1676
- 23 Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281
- 24 Priemel M. von Domarus C. Klatte TO. et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 2010; 25: 305-312
- 25 Linseisen J. Bechthold A. Bischoff-Ferrari HA. et al. Vitamin D Prävention ausgewählter chronischer Krankheiten. Bonn: Stellungnahme der Deutschen Gesellschaft für Ernährung e. V.; 2011
- 26 Chung M. Lee J. Terasawa T. et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155: 827-838
- 27 Bischoff-Ferrari HA. Willett WC. Orav EJ. et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367: 40-49
- 28 Sanders KM. Stuart AL. Williamson EJ. et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303: 1815-1822
- 29 Bischoff-Ferrari HA. Dawson-Hughes B. Orav EJ. et al. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med 2016; 4: 1-10 [Epub ahead of print]
- 30 Zittermann A. Iodice S. Pilz S. et al. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 2012; 95: 91-100
- 31 Bjelakovic G. Gluud LL. Nikolova D. et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 2014; 1
- 32 Chowdhury R. Kunutsor S. Vitezova A. et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ 2014; 348: g1903
- 33 Afzal S. Brøndum-Jacobsen P. Bojesen SE. et al. Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ 2014; 349: g6330
- 34 Bergman P. Lindh AU. Björkhem-Bergman L. et al. Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One 2013; 8: e65835
- 35 Beveridge LA. Struthers AD. Khan F. et al. D-PRESSURE Collaboration. Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. JAMA Intern Med 2015; 175: 745-754
- 36 Vimaleswaran KS. Cavadino A. Berry DJ. et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014; 2: 719-729
- 37 Brown J. Nunez S. Russell M. et al. Hypocalcemic rickets and dilated cardiomyopathy: case reports and review of literature. Pediatr Cardiol 2009; 30: 818-823
- 38 Shedeed SA. Vitamin D supplementation in infants with chronic congestive heart failure. Pediatr Cardiol 2012; 33: 713-719
- 39 Gotsman I. Shauer A. Zwas DR. et al. Vitamin D deficiency is a predictor of reduced survival in patients with heart failure; vitamin D supplementation improves outcome. Eur J Heart Fail 2012; 14: 357-366
- 40 Ford JA. MacLennan GS. Avenell A. et al. RECORD Trial Group. Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis. Am J Clin Nutr 2014; 100: 746-755
- 41 Sempos CT. Vesper HW. Phinney KW. et al. Vitamin D Standardization Program (VDSP). Vitamin D status as an international issue: national surveys and the problem of standardization. Scand J Clin Lab Invest Suppl 2012; 243: 32-40
- 42 Cashman KD. Seamans KM. Lucey AJ. et al. Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr 2012; 95: 1350-1356
- 43 Godar DE. Landry RJ. Lucas AD. Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma. Med Hypotheses 2009; 72: 434-443
- 44 Hirvonen T. Sinkko H. Valsta L. et al. Development of a model for optimal food fortification: vitamin D among adults in Finland. Eur J Nutr 2007; 46: 264-270
- 45 Zheng YT. Cui QQ. Hong YM. et al. A meta-analysis of high dose, intermittent vitamin D supplementation among older adults. PLoS One 2015; 10: e0115850