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Ultrasound Int Open 2017; 03(01): E8-E12
DOI: 10.1055/s-0042-123840
Reviiew
© Georg Thieme Verlag KG Stuttgart · New York

Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy – A Case Report and Review of the Literature

Yannick Hurni
1   Obstetrics and Gynecology, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland
,
Francesco Vigo
2   Obstetrics and Gynecology, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland
,
Begoña Lipp von Wattenwyl
2   Obstetrics and Gynecology, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland
,
Nicole Ochsenbein
3   Department of Obstetrics, University Hospital Zurich, Zürich, Switzerland
,
Claudia Canonica
2   Obstetrics and Gynecology, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland
› Author Affiliations
Further Information

Publication History

received 31 March 2016
revised 31 July 2016

accepted 05 December 2016

Publication Date:
09 February 2017 (online)

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Abstract

Fetal cholelithiasis is a rare finding during a third-trimester ultrasound with an average incidence rate of 0.07–1.15%. We report a case of fetal cholelithiasis in twins, observed in a patient with monochorionic diamniotic twin pregnancy hospitalized at our unit for signs of premature labor. We present the outcome of the 2 neonates with a clinical and sonographic follow-up. In addition, we offer a comprehensive review of the literature available to date.

Key words

fetal cholelithiasis - fetal gallstones - intrahepatic cholestasis of pregnancy
 

  • References

  • 1 Potter AH. Gall-bladder disease in young subjects. Surg Gynecol Obstet 1928; 46: 795-808
    PubMedSearch in Google Scholar
  • 2 Beretsky I, Lankin DH. Diagnosis of fetal cholelithiasis using real-time high-resolution imaging employing digital detection. J Ultrasound Med 1983; 2: 381-383
    CrossrefPubMedSearch in Google Scholar
  • 3 Devonald KJ, Ellwood DA, Colditz PB. The variable appearances of fetal gallstones. J Ultrasound Med 1992; 11: 579-585
    CrossrefPubMedSearch in Google Scholar
  • 4 Kiserud T, Gjelland K, Bognø H, Waardal M, Reigstad H, Rosendahl K. Echogenic material in the fetal gallbladder and fetal disease. Ultrasound Obstet Gynecol 1997; 10: 103-106
    CrossrefPubMedSearch in Google Scholar
  • 5 Agnifili A, Verzaro R, Carducci G, Mancini E, Gola P, Marino M et al. Fetal cholelithiasis: a prospective study of incidence, predisposing factors, and ultrasonographic and clinical features. Clin Pediatr (Phila) 1999; 38: 371-373
    CrossrefPubMedSearch in Google Scholar
  • 6 Müller R, Döhmann S, Kordts U. Fetale Gallenblase und Gallensteine. Ultraschall Med 2000; 21: 142-144
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Cancho Candela R, Díaz González J, Perandones Fernández C, Viñuela Rueda B, Relea Sarabia A, Andrés de Llano JM. Material ecogénico en vesícula biliar fetal: diagnóstico prenatal y seguimiento posnatal. An Pediatr (Barc) 2004; 61: 326-329
    CrossrefPubMedSearch in Google Scholar
  • 8 Munjuluri N, Elgharaby N, Acolet D, Kadir RA. Fetal gallstones. Fetal Diagn Ther 2005; 20: 241-243
    CrossrefPubMedSearch in Google Scholar
  • 9 Svensson J, Makin E. Gallstone disease in children. Semin Pediatr Surg 2012; 21: 255-265
    CrossrefPubMedSearch in Google Scholar
  • 10 Afdhal NH. Epidemiology, risk factors, and pathogenesis of gallstones. In: Afdhal NH. (ed.) Gallbladder and Biliary Tract Diseases. New York: Marcel Dekker, Inc.; 2000: 127-146
    Search in Google Scholar
  • 11 Iroh Tam P-Y, Angelides A. Perinatal detection of gallstones in siblings. Am J Perinatol 2010; 27: 771-774
    Thieme ConnectPubMedSearch in Google Scholar
  • 12 Abbitt PL, McIlhenny J. Prenatal detection of gallstones. J Clin Ultrasound 1990; 18: 202-204
    CrossrefPubMedSearch in Google Scholar
  • 13 Broussin B, Daube E. La lithiase vésiculaire foetale. A propos de trois observations et revue de la littérature. J Gynecol Obstet Biol Reprod (Paris) 1990; 19: 90-95
    PubMedSearch in Google Scholar
  • 14 Brown DL, Teele RL, Doubilet PM, DiSalvo DN, Benson CB, Van Alstyne GA. Echogenic material in the fetal gallbladder: sonographic and clinical observations. Radiology 1992; 182: 73-76
    CrossrefPubMedSearch in Google Scholar
  • 15 Clarke JP, Roman JD. The outcome of two cases of fetal cholelithiasisN Z Med J. 1994 107. 270
    PubMedSearch in Google Scholar
  • 16 Heijne L, Ednay D. The development of fetal gallstones demonstrated by ultrasound. Radiography 1985; 51: 155-156
    PubMedSearch in Google Scholar
  • 17 Hertzberg BS, Kliewer MA. Fetal gallstones in a contracted gallbladder: potential to simulate hepatic or peritoneal calcification. J Ultrasound Med 1998; 17: 667-670
    CrossrefPubMedSearch in Google Scholar
  • 18 Holloway S, Edwards H. Antenatal diagnosis of fetal cholelithiasis. Ultrasound 2010; 18: 152-154
    CrossrefPubMedSearch in Google Scholar
  • 19 Klingensmith WC, Cioffi-Ragan DT. Fetal gallstones. Radiology 1988; 167: 143-144
    CrossrefPubMedSearch in Google Scholar
  • 20 Lariviere M. Having K, Bullock S. Fetal Cholelithiasis. Journal of Diagnostic Medical Sonography 2006; 22: 403-406
    CrossrefPubMedSearch in Google Scholar
  • 21 López Gutiérrez JC, Ros Mar Z, López Santamaría M, Díez Pardo JA, González Gonzalez A, Pastor Abascal I et al. Colelitiasis fetal. Caso clínico y revisión de la literatura. An Esp Pediatr 1990; 32: 468-469
    PubMedSearch in Google Scholar
  • 22 Nishi T. Ultrasonographic diagnosis of fetal cholelithiasis. J Obstet Gynaecol Res 1997; 23: 251-254
    CrossrefPubMedSearch in Google Scholar
  • 23 Ozgun MT, Batukan C, Ozcelik B, Serin S, Basbug M. Prenatal sonographic diagnosis of fetal gallstones: a case report. Ultrasound Obstet Gynecol 2006; 28: 535-536
    PubMedSearch in Google Scholar
  • 24 Petrikovsky B, Klein V, Holsten N. Sludge in fetal gallbladder: natural history and neonatal outcome. Br J Radiol 1996; 69: 1017-1018
    CrossrefPubMedSearch in Google Scholar
  • 25 Sepulveda W, Stagiannis KD. Echogenic material in the fetal gallbladder in a surviving monochorionic twin. Pediatr Radiol 1996; 26: 129-130
    CrossrefPubMedSearch in Google Scholar
  • 26 Sheiner E, Abramowicz JS, Hershkovitz R. Fetal gallstones detected by routine third trimester ultrasound. Int J Gynaecol Obstet 2006; 92: 255-256
    CrossrefPubMedSearch in Google Scholar
  • 27 Stringer MD, Lim P, Cave M, Martinez D, Lilford RJ. Fetal gallstones. J Pediatr Surg 1996; 31: 1589-1591
    CrossrefPubMedSearch in Google Scholar
  • 28 Suchet IB, Labatte MF, Dyck CS, Salgado LA. Fetal cholelithiasis: a case report and review of the literature. J Clin Ultrasound 1993; 21: 198-202
    CrossrefPubMedSearch in Google Scholar
  • 29 Suma V, Marini A, Bucci N, Toffolutti T, Talenti E. Fetal gallstones: sonographic and clinical observations. Ultrasound Obstet Gynecol 1998; 12: 439-441
    CrossrefPubMedSearch in Google Scholar
  • 30 Triunfo S, Rosati P, Ferrara P, Gatto A, Scambia G. Fetal cholelithiasis: a diagnostic update and a literature review. Clin Med Insights Case Rep 2013; 6: 153-158
    PubMedSearch in Google Scholar
  • 31 Troyano-Luque J, Padilla-Pérez A, Martínez-Wallin I, Alvarez de la Rosa M, Mastrolia SA, Trujillo JL et al. Short and long term outcomes associated with fetal cholelithiasis: a report of two cases with antenatal diagnosis and postnatal follow-up. Case Rep Obstet Gynecol 2014;
    PubMedSearch in Google Scholar
  • 32 Rodríguez Rangel DA, Pinilla Orejarena AP, Bustacara Diaz M, Henao García L, López Cadena A, Montoya Camargo R et al. Cálculos biliares asociados al uso de ceftriaxona en niños. Anales de Pediatría 2014; 80: 77-80
    CrossrefPubMedSearch in Google Scholar
  • 33 Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol 2009; 15: 2049-2066
    CrossrefPubMedSearch in Google Scholar
  • 34 Almashhrawi AA, Ahmed KT, Rahman RN, Hammoud GM, Ibdah JA. Liver diseases in pregnancy: diseases not unique to pregnancy. World J Gastroenterol 2013; 19: 7630-7638
    CrossrefPubMedSearch in Google Scholar
  • 35 Moon MH, Cho JY, Kim JH, Lee YH, Jung SI, Lee MS et al. In Utero Development of the Fetal Gall Bladder in the Korean Population. Korean Journal of Radiology 2008; 9: 54-58
    CrossrefPubMedSearch in Google Scholar
  • 36 Albay S, Malas MA, Koyuncu E, Evcil EH. Morphometry of the gallbladder during the fetal period. Surg Radiol Anat 2010; 32: 363-369
    CrossrefPubMedSearch in Google Scholar
  • 37 Gertner M, Farmer DL. Laparoscopic cholecystecomy in a 16-day-old infant with chronic cholelithiasis. J Pediatr Surg 2004; 39: E17-E19
    PubMedSearch in Google Scholar