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Ultrasound Int Open 2017; 03(01): E13-E24
DOI: 10.1055/s-0042-123841
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn’s Disease: An Observational Comparison Study

Rune Wilkens
1   Divisions of Medicine and Radiology, Diagnostic Centre, Silkeborg Regional Hospital, University Research Clinic for Innovative Diagnostic Pathways, Silkeborg, Denmark
3   Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C, Denmark
,
David A. Peters
2   Department of Clinical Engineering, Aarhus University Hospital, Aarhus N, Denmark
,
Agnete H. Nielsen
1   Divisions of Medicine and Radiology, Diagnostic Centre, Silkeborg Regional Hospital, University Research Clinic for Innovative Diagnostic Pathways, Silkeborg, Denmark
,
Valeriya P. Hovgaard
1   Divisions of Medicine and Radiology, Diagnostic Centre, Silkeborg Regional Hospital, University Research Clinic for Innovative Diagnostic Pathways, Silkeborg, Denmark
,
Henning Glerup
1   Divisions of Medicine and Radiology, Diagnostic Centre, Silkeborg Regional Hospital, University Research Clinic for Innovative Diagnostic Pathways, Silkeborg, Denmark
,
Klaus Krogh
3   Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C, Denmark
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Weitere Informationen

Publikationsverlauf

received 31. Mai 2016
revised   19. September 2016

accepted 04. Dezember 2016

Publikationsdatum:
06. März 2017 (online)

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Abstract

Purpose e Cross-sectional imaging methods are important for objective evaluationof small intestinal inflammationinCrohn’sdisease(CD).The primary aim was to compare relative parameters of intestinal perfusion between contrast-enhanced ultrasonography (CEUS) and dynamic contrast-enhanced magnetic resonance enterography (DCE-MRE) in CD. Furthermore, we aimed at testing the repeatability of regions of interest (ROIs) for CEUS.

Methods This prospective study included 25 patients: 12 females (age: 37, range: 19–66) with moderate to severe CD and a bowel wall thickness>3mm evaluated with DCE-MRE and CEUS. CEUS bolus injection was performed twice for repeatability and analyzed in VueBox®. Correlations between modalities were described with Spearman’s rho, limits of agreement(LoA) and intraclass correlation coefficient(ICC). ROIrepeatability for CEUS was assessed.

Results s The correlation between modalities was good and very good for bowel wall thickness (ICC=0.71, P<0.001) and length of the inflamed segment (ICC=0.89, P<0.001). Moderate-weak correlations were found for the time-intensity curve parameters: peak intensity (r=0.59, P=0.006), maximum wash-in-rate (r=0.62, P=0.004), and wash-in perfusion index (r=0.47, P=0.036). Best CEUS repeatability for peak enhancement was a mean difference of 0.73 dB (95% CI: 0.17 to 1.28, P=0.01) and 95% LoA from −3.8 to 5.3 dB. Good quality of curve fit improved LoA to −2.3 to 2.8 dB.

Conclusion The relative perfusion of small intestinal CD assessed with DCE-MRE and CEUS shows only a moderate correlation. Applying strict criteria for ROIs is important and allows for good CEUS repeatability

Key words

ultrasonography - magnetic resonance imaging - Crohn’s disease - reproducibility of results - contrast media
 

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