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Semin Thromb Hemost 2022; 48(03): 274-276
DOI: 10.1055/s-0042-1742737
Preface

Hemostasis and Neuroscience—Hemostasis and Fibrinolysis Involved in Brain Pathology and Brain Disorders

Christine Lodberg Hvas
1   Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark
2   Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
,
Hau C. Kwaan
3   Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Anne-Mette Hvas
2   Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
4   Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
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Vascular occlusive events and hemorrhage in the brain affect thousands of lives across the globe every day. Thrombosis and hemostasis impact outcome after cerebrovascular disease, and its prevention and treatment include manipulation of systemic coagulation factors. The brain also has its own unique system for regulation of hemostasis.[1] Local thrombin generation in the brain affects the prognosis in epileptic seizures and multiple sclerosis,[2] while tissue plasminogen activator (tPa) affects blood–brain barrier permeability and is involved in Alzheimer's disease pathology.[3] This issue of Seminars of Thrombosis and Hemostasis will, in three parts, shed light on mechanisms and potential treatment targets in vascular occlusive events, in intracerebral and subarachnoid hemorrhage, and finally in the role of platelets and endogenous tPa in Alzheimer's and Parkinson's diseases.



Publication History

Article published online:
12 April 2022

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