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CC BY 4.0 · Rev Bras Ginecol Obstet 2022; 44(07): 701-709
DOI: 10.1055/s-0042-1744288
Review Article

Relation between Selenium and Female Fertility: A Systematic Review

Relação entre o selênio e a fertilidade feminina: Uma revisão sistemática
Luiz Gustavo Lima 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
,
André Amaro Mamédio dos Santos 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
,
Tiago Daniel Gueiber 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
,
Ricardo Zanetti Gomes 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
,
Camila Marinelli Martins 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
,
Andrielle Cristina Chaikoski 
1   Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil
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Abstract

Objective To analyze the influence of selenium in female fertility.

Data source A search was performed in the following databases: MEDLINE, Web of Science, Scopus, SciELO, LILACS, MDPI, ScienceDirect, and Europe PMC. The descriptors selected were “selenium” AND “female” AND “fertility”. The search interval was from 1996 to 2021.

Study selection The evaluation was performed independently by two reviewers, and a third reviewer confirmed the inclusion of papers in case of divergence between the first two reviewers. Papers were selected after the title and abstract were read, and those that met the eligibility criteria had the full text read.

Data collection The following data was extracted: author, year of publication, country, type of study, objective, method, sample size, follow-up period, patients' mean age, inclusion and exclusion criteria, and concentration of serum and capillary selenium. The data was organized in chronological order of paper publication.

Data synthesis The number of papers identified totaled 3,800, out of which 7 were included in the systematic review. The studies indicated a positive correlation between serum selenium and antioxidant concentration in the follicular fluid, reduction in antithyroid antibodies, oocyte production and follicle number.

Conclusion Selenium supplementation is promising in women with this micronutrient deficiency to promote improvement of the reproductive efficiency and prevent damage to the pregnancy. Further studies on this theme are still required.

Resumo

Objetivo Analisar a influência do selênio na fertilidade feminina.

Fonte dos dados Uma busca foi realizada nas seguintes bases de dados: MEDLINE, Web of Science, Scopus, SciELO, LILACS, MDPI, ScienceDirect e Europe PMC. Os descritores selecionados foram “selenium” AND “female” AND “fertility”. O intervalo de busca foi de 1996 a 2021.

Seleção dos estudos A avaliação ocorreu de maneira independente por dois revisores, sendo que um terceiro corroborou a eleição dos artigos em casos de divergência. Os estudos foram selecionados através da leitura do título e resumo, e aqueles que contemplaram os critérios de elegibilidade foram lidos na íntegra.

Coleta dos dados Os seguintes dados foram extraídos: autor, ano de publicação, país, tipo de estudo, objetivo, método, tamanho da amostra, tempo de acompanhamento, média de idade das pacientes, critérios de inclusão e exclusão, concentração de selênio sérico e capilar. Os dados foram organizados em ordem cronológica de publicação do estudo.

Síntese dos dados Foram identificados 3.800 artigos e incluídos 7 estudos na revisão sistemática. Os resultados indicaram correlação positiva entre o nível de selênio sérico e a concentração de antioxidantes no fluido folicular; diminuição dos níveis de anticorpos antitireoidianos; produção de oócitos, e número de folículos.

Conclusão A suplementação de selênio é promissora em mulheres com deficiência do micronutriente, a fim de promover melhora na eficiência reprodutiva e prevenir danos na gravidez. Salientou-se a necessidade de realização de mais estudos sobre o tema.

Keywords

selenium - fertility agents, female - reproduction

Palavras-chave

selênio - fármacos para a fertilidade feminina - reprodução


Publication History

Received: 19 August 2021

Accepted: 03 January 2022

Article published online:
03 June 2022

© 2022. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Qazi IH, Angel C, Yang H. , Pan B, Zoidis E, Zeng CJ, et al. Selenium, selenoproteins, and female reproduction: a review. Molecules 2018; 23 (12) 3053
    CrossrefPubMedSearch in Google Scholar
  • 2 Pieczyńska J, Grajeta H. The role of selenium in human conception and pregnancy. J Trace Elem Med Biol 2015; 29: 31-38
    CrossrefPubMedSearch in Google Scholar
  • 3 Finley JW. Bioavailability of selenium from foods. Nutr Rev 2006; 64 (03) 146-151
    CrossrefPubMedSearch in Google Scholar
  • 4 Hariharan S, Dharmaraj S. Selenium and selenoproteins: it's role in regulation of inflammation. Inflammopharmacology 2020; 28 (03) 667-695
    CrossrefPubMedSearch in Google Scholar
  • 5 Chun OK, Floegel A, Chung SJ, Chung CE, Song WO, Koo SI. Estimation of antioxidant intakes from diet and supplements in U.S. adults. J Nutr 2010; 140 (02) 317-324
    CrossrefPubMedSearch in Google Scholar
  • 6 Mistry HD, Broughton Pipkin F, Redman CW, Poston L. Selenium in reproductive health. Am J Obstet Gynecol 2012; 206 (01) 21-30
    CrossrefPubMedSearch in Google Scholar
  • 7 Institute of Medicine. Panel on Dietary Antioxidants and Related Compounds. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids.. Washington (DC):: National Academies Press;; 2000
    Search in Google Scholar
  • 8 Ashton K, Hooper L, Harvey LJ, Hurst R, Casgrain A, Fairweather-Tait SJ. Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr 2009; 89 (06) 2025S-2039S
    CrossrefPubMedSearch in Google Scholar
  • 9 Muntau AC, Streiter M, Kappler M. , Röschinger W, Schmid I, Rehnert A, et al. Age-related reference values for serum selenium concentrations in infants and children. Clin Chem 2002; 48 (03) 555-560
    CrossrefPubMedSearch in Google Scholar
  • 10 Schrauzer GN, White DA. Selenium in human nutrition: dietary intakes and effects of supplementation. Bioinorg Chem 1978; 8 (04) 303-318
    CrossrefPubMedSearch in Google Scholar
  • 11 Yan J, Wang F, Qin H. , Guoxiong C, Eviatar N, Fahima T, and Jianping C. Natural variation in grain selenium concentration of wild barley, Hordeum spontaneum, populations from Israel. Biol Trace Elem Res 2011; 142 (03) 773-786
    CrossrefPubMedSearch in Google Scholar
  • 12 Hatfield DL, Berry MJ, Gladyshev VN. Selenium: its molecular biology and role in human health. 3rd ed. New York: Springer; 2012
    CrossrefSearch in Google Scholar
  • 13 Pappas AC, Zoidis E, Surai PF, Zervas G. Selenoproteins and maternal nutrition. Comp Biochem Physiol B Biochem Mol Biol 2008; 151 (04) 361-372
    CrossrefPubMedSearch in Google Scholar
  • 14 Banu SK, Stanley JA, Arosh JA, Aruldhas MM. Metals in female reproduction. In: Skinner MK, editor. Encyclopedia of reproduction. 2nd ed. San Diego: Academic Press; 2018: 714-722
    Search in Google Scholar
  • 15 Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004; 5 (01) 1-10
    CrossrefPubMedSearch in Google Scholar
  • 16 Tremellen K. Oxidative stress and male infertility–a clinical perspective. Hum Reprod Update 2008; 14 (03) 243-258
    CrossrefPubMedSearch in Google Scholar
  • 17 Ceko MJ, Hummitzsch K, Hatzirodos N. , Bonner WM, Aitken JB, Russell DL, et al. X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function. Metallomics 2015; 7 (01) 71-82
    CrossrefPubMedSearch in Google Scholar
  • 18 Takagi Y, Nikaido T, Toki T. , Kita N, Kanai M, Ashida T, et al. Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 2004; 444 (01) 49-55
    CrossrefPubMedSearch in Google Scholar
  • 19 Mintziori G, Mousiolis A, Duntas LH, Goulis DG. Evidence for a manifold role of selenium in infertility. Hormones (Athens) 2020; 19 (01) 55-59
    CrossrefPubMedSearch in Google Scholar
  • 20 Agarwal A, Durairajanayagam D, du Plessis SS. Utility of antioxidants during assisted reproductive techniques: an evidence based review. Reprod Biol Endocrinol 2014; 12: 112
    CrossrefPubMedSearch in Google Scholar
  • 21 Rayman MP, Searle E, Kelly L. , Johnsen S, Bodman-Smith K, Bath SC, et al. Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. Br J Nutr 2014; 112 (01) 99-111
    CrossrefPubMedSearch in Google Scholar
  • 22 Tremellen K, Miari G, Froiland D, Thompson J. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust N Z J Obstet Gynaecol 2007; 47 (03) 216-221
    CrossrefPubMedSearch in Google Scholar
  • 23 Moslemi MK, Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011; 4: 99-104
    CrossrefPubMedSearch in Google Scholar
  • 24 Özkaya MO, Nazıroğlu M, Barak C, Berkkanoglu M. Effects of multivitamin/mineral supplementation on trace element levels in serum and follicular fluid of women undergoing in vitro fertilization (IVF). Biol Trace Elem Res 2011; 139 (01) 1-9
    CrossrefPubMedSearch in Google Scholar
  • 25 Grabek M, Swies Z, Borzecki A. The influence of selenium on the reproduction of rats. Ann Univ Mariae Curie Sklodowska Med 1991; 46: 103-105
    PubMedSearch in Google Scholar
  • 26 Grazul-Bilska AT, Vonnahme KA, Bilski JJ. , Borowczyk E, Soni D, Mikkelson B, Johnson ML, et al. Expression of gap junctional connexin proteins in ovine fetal ovaries: effects of maternal diet. Domest Anim Endocrinol 2011; 41 (04) 185-194
    CrossrefPubMedSearch in Google Scholar
  • 27 Javidi H, Vettore M, Benson PE. Does orthodontic treatment before the age of 18 years improve oral health-related quality of life? A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop 2017; 151 (04) 644-655
    CrossrefPubMedSearch in Google Scholar
  • 28 Beardsley C, Škarabot J. Effects of self-myofascial release: A systematic review. J Bodyw Mov Ther 2015; 19 (04) 747-758
    CrossrefPubMedSearch in Google Scholar
  • 29 Kim K, Wactawski-Wende J, Michels KA. , Schliep KC, Plowden TC, Chaljub EN, Mumford SL. Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles. Br J Nutr 2018; 120 (01) 81-89
    CrossrefPubMedSearch in Google Scholar
  • 30 Dickerson EH, Sathyapalan T, Knight R. , Maguiness SM, Killick SR, Robinson J, Atkin SL. Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. J Assist Reprod Genet 2011; 28 (12) 1223-1228
    CrossrefPubMedSearch in Google Scholar
  • 31 Singh AK, Chattopadhyay R, Chakravarty B, Chaudhury K. Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reprod Toxicol 2013; 42: 116-124
    CrossrefPubMedSearch in Google Scholar
  • 32 Ambroziak U, Hybsier S, Shahnazaryan U. , Krasnodębska-Kiljańska M, Rijntjes E, Bartoszewicz Z, et al. Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake. J Trace Elem Med Biol 2017; 44: 186-191
    CrossrefPubMedSearch in Google Scholar
  • 33 Lozano M, Murcia M, Soler-Blasco R. , Iñiguez C, Irizar A, Lertxundi A, et al. Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain). Environ Res 2020; 181: 108943
    CrossrefPubMedSearch in Google Scholar
  • 34 Thomas VV, Knight R, Haswell SJ, Lindow SW, van der Spuy ZM. Maternal hair selenium levels as a possible long-term nutritional indicator of recurrent pregnancy loss. BMC Womens Health 2013; 13: 40
    CrossrefPubMedSearch in Google Scholar
  • 35 Mantovani G, Isidori AM, Moretti C. , Di Dato C, Greco E, Ciolli P, et al. Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial. Endocrine 2019; 66 (03) 542-550
    CrossrefPubMedSearch in Google Scholar
  • 36 Maeda E, Murata K, Kumazawa Y. , Sato W, Shirasawa H, Iwasawa T, et al. Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study. Environ Res 2019; 168: 357-363
    CrossrefPubMedSearch in Google Scholar
  • 37 Paszkowski T, Traub AI, Robinson SY, McMaster D. Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin Chim Acta 1995; 236 (02) 173-180
    CrossrefPubMedSearch in Google Scholar
  • 38 Razavi M, Jamilian M, Kashan ZF. , Heidar Z, Mohseni M, Ghandi Y, et al. Selenium supplementation and the effects on reproductive outcomes, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome. Horm Metab Res 2016; 48 (03) 185-190
    Thieme ConnectPubMedSearch in Google Scholar
  • 39 Zuo Y, Li Y, Gu X, Lei Z. The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis. Ann Palliat Med 2021; 10 (04) 4398-4408
    CrossrefPubMedSearch in Google Scholar
  • 40 Meyer AM, Reed JJ, Neville TL. , Taylor JB, Hammer CJ, Reynolds LP, et al. Effects of plane of nutrition and selenium supply during gestation on ewe and neonatal offspring performance, body composition, and serum selenium. J Anim Sci 2010; 88 (05) 1786-1800
    CrossrefPubMedSearch in Google Scholar
  • 41 Vonnahme KA, Luther JS, Reynolds LP. , Hammer CJ, Carlson DB, Redmer DA, Caton JS. Impacts of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspring in sheep. Domest Anim Endocrinol 2010; 39 (04) 240-248
    CrossrefPubMedSearch in Google Scholar
  • 42 Gierus M. Fontes orgânicas e inorgânicas de selênio na nutrição de vacas leiteiras: digestão, absorção, metabolismo e exigências. Cienc Rural 2017; 37 (04) 1212-1220
    CrossrefPubMedSearch in Google Scholar
  • 43 Lewandowska M, Sajdak S, Lubiński J. Serum selenium level in early healthy pregnancy as a risk marker of pregnancy induced hypertension. Nutrients 2019; 11 (05) 1028
    CrossrefPubMedSearch in Google Scholar