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Semin intervent Radiol 2022; 39(02): 162-166
DOI: 10.1055/s-0042-1745794
Review Article

Basivertebral Nerve Ablation

Junjian Huang
1   Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
,
Kevin Delijani
2   Georgetown Medical School, Washington, District of Columbia
,
Jesse Jones
3   Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama
,
John Di Capua
4   Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
,
Husamuddin El Khudari
1   Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
,
Andrew J. Gunn
1   Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
,
Joshua A. Hirsch
4   Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
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Basivertebral Nerve AblationSemin intervent Radiol 2022; 39(02): e1-e1
DOI: 10.1055/s-0042-1756329

Abstract

Low back pain is one of the most prevalent musculoskeletal ailments in the United States. Intraosseous radiofrequency ablation of the basivertebral nerve is an effective and durable therapy for low back pain and can be offered to patients who have chronic low back pain of greater than 6 months of duration, failure to respond to noninvasive therapies for 6 months, with either Modic Type I or Type II changes at L3–S1. This article reviews the anatomy and physiology, patient selection, technique, and evidence regarding basivertebral nerve ablation.

Keywords

interventional radiology - pain management - basivertebral nerve - nerve ablation


Publication History

Article published online:
30 June 2022

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  • References

  • 1 Wu A, March L, Zheng X. et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med 2020; 8 (06) 299
    CrossrefPubMedGoogle Scholar
  • 2 Lorio M, Clerk-Lamalice O, Beall DP, Julien T. International Society for the Advancement of Spine Surgery Guideline - intraosseous ablation of the basivertebral nerve for the relief of chronic low back pain. Int J Spine Surg 2020; 14 (01) 18-25
    CrossrefPubMedGoogle Scholar
  • 3 Deyo RA, Mirza SK, Martin BI. Back pain prevalence and visit rates: estimates from U.S. national surveys, 2002. Spine 2006; 31 (23) 2724-2727
    CrossrefPubMedGoogle Scholar
  • 4 Leggett LE, Soril LJ, Lorenzetti DL. et al. Radiofrequency ablation for chronic low back pain: a systematic review of randomized controlled trials. Pain Res Manag 2014; 19 (05) e146-e153
    CrossrefPubMedGoogle Scholar
  • 5 Botwin KP, Gruber RD, Bouchlas CG. et al. Complications of fluoroscopically guided caudal epidural injections. Am J Phys Med Rehabil 2001; 80 (06) 416-424
    CrossrefPubMedGoogle Scholar
  • 6 Golden N. ISASS Guideline. ISASS, December 10, 2019, Accessed October 9, 2021 at: www.isass.org/isass-guideline-intraosseous-ablation-of-the-basivertebral-nerve-for-the-relief-of-chronic-low-back-pain/
    PubMedGoogle Scholar
  • 7 Urits I, Noor N, Johal AS. et al. Basivertebral nerve ablation for the treatment of vertebrogenic pain. Pain Ther 2021; 10 (01) 39-53
    CrossrefPubMedGoogle Scholar
  • 8 Bailey JF, Liebenberg E, Degmetich S, Lotz JC. Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra. J Anat 2011; 218 (03) 263-270
    CrossrefPubMedGoogle Scholar
  • 9 Zhao Q, Cheng L, Yan H. et al. The anatomical study and clinical significance of the sinuvertebral nerves at the lumbar levels. Spine 2020; 45 (02) E61-E66
    CrossrefPubMedGoogle Scholar
  • 10 Standring S. Gray's Anatomy: The Anatomical Basis of Clinical Practice. 41st ed.. New York: Elsevier; 2016: 734-767
    Google Scholar
  • 11 Klawitter M, Hakozaki M, Kobayashi H. et al. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. Eur Spine J 2014; 23 (09) 1878-1891
    CrossrefPubMedGoogle Scholar
  • 12 Thomas GP, Hemmrich K, Abberton KM. et al. Zymosan-induced inflammation stimulates neo-adipogenesis. Int J Obes 2008; 32 (02) 239-248
    CrossrefPubMedGoogle Scholar
  • 13 Torkki M, Majuri ML, Wolff H. et al. Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus. Eur Spine J 2016; 25 (01) 207-216
    CrossrefPubMedGoogle Scholar
  • 14 Becker S, Hadjipavlou A, Heggeness MH. Ablation of the basivertebral nerve for treatment of back pain: a clinical study. Spine J 2017; 17 (02) 218-223
    CrossrefPubMedGoogle Scholar
  • 15 Khalil JG, Smuck M, Koreckij T. et al; INTRACEPT Trial Investigators. A prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain. Spine J 2019; 19 (10) 1620-1632
    CrossrefPubMedGoogle Scholar
  • 16 Fischgrund JS, Rhyne A, Franke J. et al. Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study. Eur Spine J 2018; 27 (05) 1146-1156
    CrossrefPubMedGoogle Scholar
  • 17 Fischgrund JS, Rhyne A, Macadaeg K. et al. Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study. Eur Spine J 2020; 29 (08) 1925-1934
    CrossrefPubMedGoogle Scholar