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Semin intervent Radiol 2022; 39(02): 125-129
DOI: 10.1055/s-0042-1745798
Review Article

Genicular Artery Embolization for Primary Knee Osteoarthritis

Ravi Tyagi
1   University of Illinois College of Medicine at Chicago, Chicago, Illinois
,
S. Samaduddin Ahmed
2   Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois
,
Yilun Koethe
3   Dotter Department of Interventional Radiology, Oregon Health and Science University, Portland, Oregon
,
Aleksandr Raskind
2   Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois
,
Osman Ahmed
4   Section of Interventional Radiology, Department of Radiology, University of Chicago, Chicago, Illinois
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Abstract

Genicular artery embolization (GAE) is a novel treatment for knee osteoarthritis (OA) with increasing interest and utilization worldwide. The genicular arteries are selectively embolized using microspheres with subsequent cessation of abnormal synovial hyperemia, a process believed to arrest the inflammatory changes and pain associated with OA. Current data indicate that GAE offers sustained, 6-month improvement in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and visual analog scale scores in 80 to 85% of patients with mild to moderate OA. As GAE gains traction, future studies are needed to establish its safety and efficacy relative to placebo and other standard-of-care therapies while also characterizing populations for which it is most effective.

Keywords

GAE - genicular artery embolization - osteoarthritis - embolization - WOMAC - WORMS - VAS - interventional radiology


Publikationsverlauf

Artikel online veröffentlicht:
30. Juni 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Goldman DT, Piechowiak R, Nissman D, Bagla S, Isaacson A. Current concepts and future directions of minimally invasive treatment for knee pain. Curr Rheumatol Rep 2018; 20 (09) 54
    CrossrefPubMedSuche in Google Scholar
  • 2 Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 2005; 44 (01) 7-16
    CrossrefPubMedSuche in Google Scholar
  • 3 Ashraf S, Mapp PI, Walsh DA. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum 2011; 63 (09) 2700-2710
    CrossrefPubMedSuche in Google Scholar
  • 4 Bagla S, Piechowiak R, Hartman T, Orlando J, Del Gaizo D, Isaacson A. Genicular artery embolization for the treatment of knee pain secondary to osteoarthritis. J Vasc Interv Radiol 2020; 31 (07) 1096-1102
    CrossrefPubMedSuche in Google Scholar
  • 5 Okuno Y, Korchi AM, Shinjo T, Kato S. Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol 2015; 38 (02) 336-343
    CrossrefPubMedSuche in Google Scholar
  • 6 Okuno Y, Korchi AM, Shinjo T, Kato S, Kaneko T. Midterm clinical outcomes and MR imaging changes after transcatheter arterial embolization as a treatment for mild to moderate radiographic knee osteoarthritis resistant to conservative treatment. J Vasc Interv Radiol 2017; 28 (07) 995-1002
    CrossrefPubMedSuche in Google Scholar
  • 7 Lee SH, Hwang JH, Kim DH. et al. Clinical outcomes of transcatheter arterial embolisation for chronic knee pain: mild-to-moderate versus severe knee osteoarthritis. Cardiovasc Intervent Radiol 2019; 42 (11) 1530-1536
    CrossrefPubMedSuche in Google Scholar
  • 8 Casadaban LC, Mandell JC, Epelboym Y. Genicular artery embolization for osteoarthritis related knee pain: a systematic review and qualitative analysis of clinical outcomes. Cardiovasc Intervent Radiol 2021; 44 (01) 1-9
    CrossrefPubMedSuche in Google Scholar
  • 9 Bagla S, Rholl KS, van Breda A, Sterling KM, van Breda A. Geniculate artery embolization in the management of spontaneous recurrent hemarthrosis of the knee: case series. J Vasc Interv Radiol 2013; 24 (03) 439-442
    CrossrefPubMedSuche in Google Scholar
  • 10 Luyckx EGR, Mondelaers AMP, van der Zijden T, Voormolen MHJ, Van den Bergh FRA, d'Archambeau OC. Geniculate artery embolization in patients with recurrent hemarthrosis after knee arthroplasty: a retrospective study. J Arthroplasty 2020; 35 (02) 550-556
    CrossrefPubMedSuche in Google Scholar
  • 11 Landers S, Hely R, Page R. et al. Genicular artery embolization to improve pain and function in early-stage knee osteoarthritis-24-month pilot study results. J Vasc Interv Radiol 2020; 31 (09) 1453-1458
    CrossrefPubMedSuche in Google Scholar
  • 12 Little MW, Gibson M, Briggs J. et al. Genicular artEry embolizatioN in patiEnts with oSteoarthrItiS of the Knee (GENESIS) using permanent microspheres: interim analysis. [published correction appears in Cardiovasc Intervent Radiol. 2021 Apr 21;] Cardiovasc Intervent Radiol 2021; 44 (06) 931-940
    CrossrefPubMedSuche in Google Scholar
  • 13 Bagla S, Piechowiak R, Hartman T. et al. 3:00 PM Abstract No. 3. DISTINGUISHED ABSTRACT multicenter prospective, randomized, sham-controlled study of genicular artery embolization. J Vasc Interv Radiol 2020; 31 (03) S6
    CrossrefPubMedSuche in Google Scholar
  • 14 Ahmed O, Block J, Mautner K. et al. Percutaneous management of osteoarthritis in the knee: proceedings from the Society of Interventional Radiology Research Consensus Panel. J Vasc Interv Radiol 2021; 32 (06) 919.e1-919.e6
    CrossrefPubMedSuche in Google Scholar
  • 15 Padia S, Plotnik A, Blumstein G. et al. Abstract No. 16 Genicular artery embolization for the treatment of knee osteoarthritis: final results from a prospective investigational device exemption trial. J Vasc Interv Radiol 2021; 32 (05) S8
    CrossrefPubMedSuche in Google Scholar