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CC BY-NC-ND 4.0 · Arch Plast Surg 2022; 49(03): 304-309
DOI: 10.1055/s-0042-1748642
Cosmetic
Original Article

Ultrasonographic Assessment of the Cutaneous Changes Induced by Topical Use of Novel Peptides Comprising Laminin 5

Kyong Chan Park
1   Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University, Bucheon, Korea
,
Se Young Kim
2   Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University, Gumi, Korea
,
Galina Khan
1   Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University, Bucheon, Korea
,
Eun Soo Park
1   Department of Plastic and Reconstructive Surgery and College of Medicine, Soonchunhyang University, Bucheon, Korea
› Author Affiliations Funding This work was supported by the Soonchunhyang University Research Fund.
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Abstract

Background Laminin 5, which is found in the basement membrane of dermal-epidermal junction (DEJ), is a major adhesive component and associated with proliferating and migrating keratinocytes. In this study, we hypothesized that the topical application of the skin care products containing the novel peptides might restore the DEJ structure by deriving deposition of laminin 5 and promoting the keratinocyte migration. Here, we evaluated the restoration of DEJ by measuring the skin thickness.

Methods Single-center retrospective analysis was performed on a total of 13 patients who underwent skin care using Baume L.C.E. (France, Laboratories d' Anjou) between January and March 2021. All patients applied the skin care agent for 2 weeks only on their left hand dorsum. Before the initiation of the application and after 2 weeks, both their hands were evaluated on photography and ultrasound. And the patients were asked to rate their satisfaction with the questionnaire after 2 weeks.

Results There was no obvious improvement in photographic assessment and questionnaire. The post–pre difference of skin thickness in ultrasound images was, in left hand, 0.1 ± 0.37 in distal point and 0.1 ± 0.35 in proximal point; and, in right hand, 0 ± 0.17 in distal point and 0 ± 0.15 in proximal point, respectively. The pre–post difference was statistically significant in proximal point (p = 0.035).

Conclusion Topical application of novel peptide derivative comprising laminin 5 demonstrated cutaneous changes including skin thickness, as assessed by ultrasound. Further studies using other modalities including dermal density measurement, three-dimensional photography, optical coherence tomography, or skin biopsy would be helpful to determine the skin-improving effects.

Keywords

basement membrane - laminin - ultrasound

Author Contributions

Conceptualization: E.S.P. Data curation: S.Y.K. and G.K. Project administration: E.S.P. Visualization: K.S.P. Writing-original draft: K.C.P. Writing-review and editing: K.C.P.


Ethical Approval

The study was approved by the Institutional Review Board of Soonchunhyang University Bucheon Hospital (IRB No. 2021–06–001) and performed in accordance with the principles of the Declaration of Helsinki.


Patient Consent

The patients provided written informed consent for the publication and the use of their images.




Publication History

Article published online:
27 May 2022

© 2022. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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