CC BY 4.0 · Rev Bras Ginecol Obstet 2022; 44(06): 609-613
DOI: 10.1055/s-0042-1748973
Review Article

Pregnancy in Patients with Non-cirrhotic Portal Hypertension: A Literature Review

Gravidez em pacientes com hipertensão portal não cirrótica: Uma revisão da literatura
1   Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
,
2   Department of Maternal and Fetal Medicine, Fernandez Hospital, Hyderabad, Telangana, India
› Author Affiliations

Abstract

Pregnancy in non-cirrhotic portal hypertension (NCPH) is an uncommon condition. Its management is challenging both to the obstetricians as well as to the gastroenterologists due to the lack of more extensive studies and standard clinical practice guidelines. These patients are at increased risk of portal hypertension (PTH) complications, especially variceal bleeding, and with an increased incidence of adverse maternal and fetal outcomes. Hence, a multidisciplinary approach is required for management of pregnancy in NCPH. This short review describes the different aspects of pregnancy with NCPH, emphasizing specific strategies for preventing and managing PTH from the preconceptional period to postpartum.

Resumo

A gravidez na hipertensão portal não cirrótica (HPNC) é uma condição incomum. Seu manejo é desafiador tanto para os obstetras quanto para os gastroenterologistas devido à falta de estudos mais extensos e diretrizes de prática clínica padrão. Esses pacientes apresentam risco aumentado de complicações da hipertensão portal (PTH) especialmente sangramento por varizes e têm maior incidência de desfechos maternos e fetais adversos. Portanto uma abordagem multidisciplinar é necessária para o manejo da gravidez na NCPH. Esta breve revisão descreve os diferentes aspectos da gravidez com HPNC enfatizando estratégias específicas para prevenção e manejo do PTH desde o período pré-concepcional até o pós-parto.



Publication History

Received: 05 October 2021

Accepted: 03 March 2022

Article published online:
27 June 2022

© 2022. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 
  • References

  • 1 Khanna R, Sarin SK. Non-cirrhotic portal hypertension - diagnosis and management. J Hepatol 2014; 60 (02) 421-441
  • 2 Gioia S, Nardelli S, Ridola L, Riggio O. Causes and management of non-cirrhotic portal hypertension. Curr Gastroenterol Rep 2020; 22 (12) 56
  • 3 Kochhar R, Kumar S, Goel RC, Sriram PV, Goenka MK, Singh K. Pregnancy and its outcome in patients with noncirrhotic portal hypertension. Dig Dis Sci 1999; 44 (07) 1356-1361
  • 4 Sandya MR, Manjula SK. Ancy Sr. Pregnancy outcome in non-cirrhotic portal hypertension. Int J Reprod Contracept Obstet Gynecol 2017; 6 (10) 4534-4537
  • 5 Keepanasseril A, Gupta A, Ramesh D, Kothandaraman K, Jeganathan YS, Maurya DK. Maternal-fetal outcome in pregnancies complicated with non-cirrhotic portal hypertension: experience from a Tertiary Centre in South India. Hepatol Int 2020; 14 (05) 842-849
  • 6 Subbaiah M, Kumar S, Roy KK, Sharma JB, Singh N. Extrahepatic portal-vein obstruction in pregnancy. Taiwan J Obstet Gynecol 2015; 54 (04) 394-397
  • 7 Aggarwal N, Chopra S, Raveendran A, Suri V, Dhiman RK, Chawla YK. Extra hepatic portal vein obstruction and pregnancy outcome: largest reported experience. J Obstet Gynaecol Res 2011; 37 (06) 575-580
  • 8 Sumana G, Dadhwal V, Deka D, Mittal S. Non-cirrhotic portal hypertension and pregnancy outcome. J Obstet Gynaecol Res 2008; 34 (05) 801-804
  • 9 Aggarwal N, Sawhney H, Vasishta K, Dhiman RK, Chawla Y. Non-cirrhotic portal hypertension in pregnancy. Int J Gynaecol Obstet 2001; 72 (01) 1-7
  • 10 Mandal D, Dattaray C, Sarkar R, Mandal S, Choudhary A, Maity TK. Is pregnancy safe with extrahepatic portal vein obstruction? An analysis. Singapore Med J 2012; 53 (10) 676-680
  • 11 Andrade F, Shukla A, Bureau C, Senzolo M, D'Alteroche L, Heurgué A. et al. VALDIG investigators. Pregnancy in idiopathic non-cirrhotic portal hypertension: A multicentric study on maternal and fetal management and outcome. J Hepatol 2018; 69 (06) 1242-1249
  • 12 Hoekstra J, Seijo S, Rautou PE, Ducarme G, Boudaoud L, Luton D. et al. Pregnancy in women with portal vein thrombosis: results of a multicentric European study on maternal and fetal management and outcome. J Hepatol 2012; 57 (06) 1214-1219
  • 13 López-Méndez E, Avila-Escobedo L. Pregnancy and portal hypertension a pathology view of physiologic changes. Ann Hepatol 2006; 5 (03) 219-223
  • 14 Aggarwal N, Negi N, Aggarwal A, Bodh V, Dhiman RK. Pregnancy with portal hypertension. J Clin Exp Hepatol 2014; 4 (02) 163-171
  • 15 Sandhu BS, Sanyal AJ. Pregnancy and liver disease. Gastroenterol Clin North Am 2003; 32 (01) 407-436 , ix
  • 16 Holdsworth RJ, Gunn A. Ruptured splenic artery aneurysm in pregnancy. A review. Br J Obstet Gynaecol 1992; 99 (07) 595-597
  • 17 Mattar SG, Lumsden AB. The management of splenic artery aneurysms: experience with 23 cases. Am J Surg 1995; 169 (06) 580-584
  • 18 Pasha SF, Gloviczki P, Stanson AW, Kamath PS. Splanchnic artery aneurysms. Mayo Clin Proc 2007; 82 (04) 472-479
  • 19 Tran TT, Ahn J, Reau NS. ACG Clinical Guideline: liver disease and pregnancy. Am J Gastroenterol 2016; 111 (02) 176-194, quiz 196
  • 20 Yakoob MY, Bateman BT, Ho E, Hernandez-Diaz S, Franklin JM, Goodman EE. et al. The risk of congenital malformations associated with exposure to β-blockers early in pregnancy: a meta-analysis. Hypertension 2013; 62 (02) 375-381
  • 21 Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Maeda A. Late pregnancy β blocker exposure and risks of neonatal hypoglycemia and bradycardia. Pediatrics 2016; 138 (03) e20160731
  • 22 Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez BoteroJ, James AH. et al. The Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients With Thrombocytopenia. Anesth Analg 2021; 132 (06) 1531-1544
  • 23 Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel BB. et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010; 115 (02) 168-186
  • 24 Dai C, Liu WX, Jiang M, Sun MJ. Endoscopic variceal ligation compared with endoscopic injection sclerotherapy for treatment of esophageal variceal hemorrhage: a meta-analysis. World J Gastroenterol 2015; 21 (08) 2534-2541
  • 25 Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology 2017; 65 (01) 310-335