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CC BY 4.0 · Eur J Dent 2023; 17(02): 337-341
DOI: 10.1055/s-0042-1749154
Original Article

Nanoparticles of Liquid Smoke Rice Husk Inhibit Porphyromonas gingivalis

Ira Arundina
1   Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Indeswati Diyatri
1   Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Wisnu Setiari Juliastuti
1   Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Theresia Indah Budhy
2   Department of Oral Pathology and Maxillofacial, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Meircurius Dwi Condro Surboyo
3   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Benni Iskandar
4   School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
5   Sekolah Tinggi Ilmu Farmasi, Pekanbaru, Riau, Indonesia
,
Anisa Nur Halimah
6   Vocational Degree, Universitas Airlangga, Surabaya, Indonesia
,
Azzahra Salsabila Adira Moelyanto
7   Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Sheryn Marcha Ramaniasari
7   Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Gustiadi Saputra
8   Magister of Immunology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
› Author Affiliations Funding This work is supported by Ministry of Higher Education Republic of Indonesia in the Schema Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) 2021 with grant number 311/UN3.15/PT/2021.
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Abstract

Objective Utilization of liquid smoke rice husk can be used as an alternative treatment because of the antimicrobial properties. Advances in drug delivery systems are increasingly developing to increase the bioavailability of drugs and reduce the side effects of these drugs, namely nanoparticles. In this study, nanoparticles of liquid smoke rice husk (nLSRH) were tested the antimicrobial against Porphyromonas gingivalis.

Materials and Method This type of research is an experimental in vitro laboratory using Porphyromonas gingivalis culture. nLSRH contained liquid smoke rice husk concentration of 1, 2.5, 5, 7.5, 10, 12.5, 15, and 17.5%. The antibacterial was performed using the dilution methods.

Results The nLRSH concentration of 1% showed clearest medium. The highest number of colonies Porphyromonas gingivalis was observed at nLSRH concentration of 1% (40.3 colony-forming unit [CFU]) and decreased at a concentration of 2.5% (11.3 CFU); other concentration or no bacterial colony growth was found. The nLSRH concentration of 2.5% can be determined as the minimum inhibitory concentration and nLSRH concentration of 5% can be determined as the minimum bactericidal concentration.

Conclusion nLSRH have antimicrobial activity against Porphyromonas gingivalis. This finding able to drive the next research to develop nLSRH as gingival and periodontitis disease is caused by Porphyromonas gingivalis.

Keywords

liquid smoke - rice husk - nanoparticle - antimicrobial - Porphyromonas gingivalis

Ethical Approval

Approval was obtained from the Ethical Clearance of Health Experimental Committee, Faculty of Dentistry, Airlangga University, Surabaya with registration number 427/HRECC.FODM/VII/2021.




Publication History

Article published online:
12 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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