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CC BY-NC-ND 4.0 · Thorac Cardiovasc Surg 2023; 71(05): 425-431
DOI: 10.1055/s-0042-1749320
Original Thoracic

Analysis of Pulmonary Function in Thymoma Subjects: A 20-Year Retrospective Cohort Study

Hongyun Ruan
1   Beijing Chest Hospital, Beijing, China
,
Bin Liu
1   Beijing Chest Hospital, Beijing, China
,
Xinting Yang
1   Beijing Chest Hospital, Beijing, China
,
Xuehui Shang
1   Beijing Chest Hospital, Beijing, China
,
Qi Li 
1   Beijing Chest Hospital, Beijing, China
› Author Affiliations Funding None.
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Abstract

Background Thymoma is the most common tumor of the anterior mediastinum. However, the correlation between thymoma stage and pulmonary function was not assessed. Our objective in this study was to describe the pulmonary function in thymoma subjects stratified with different staging systems.

Methods A total of 143 subjects with a diagnosis of thymoma who underwent extended thymectomy for thymoma between January 2001 and December 2019 were reviewed retrospectively. All the subjects experienced pulmonary function tests (PFTs) using Master Screen PFT system and total respiratory resistance measurement.

Results We evaluated 143 subjects with a diagnosis of thymoma; the significant differences were observed in mean values of vital capacity, inspiratory volume (IC), total lung capacity (TLC), ratio of residual volume to total lung capacity (RV/TLC), forced vital capacity, forced expiratory volume in 1 second, ratio of forced expiratory volume in 1 second to forced vital capacity, peak expiratory flow, peak inspiratory flow, maximum ventilation volume, total airway resistance, and diffusing capacity for carbon monoxide (DLCO) across upper airway obstruction classification. PFTs of subjects with varying Masaoka stages are different. RV and RV/TLC of subjects in stages III and IV were higher than those of normal level, while DLCO of subjects in stage IV was lower than the normal level, and the mean level of IC showed significant difference between stage II and stage III.

Discussion The pulmonary function patterns of thymoma subjects significantly correlate with tumor location and size rather than clinical Masaoka stage.

Keywords

surgery - thymoma - pulmonary function tests - upper airway obstruction (UAO) - cohort study

Ethics Approval Statement

The study design complies with the Helsinki Research Ethics Statement and was approved by the Ethics Committee of Beijing Chest Hospital (2019) interim review no. (85).


Authors' Contribution

Q.L., X.S., H.R., B.L., and X.Y. designed and supervised the project. H.R. and B.L. collected the clinical samples. H.R. did postoperative patient follow-up. H.R gathered and processed the data. H.R. and B.L. performed the data analysis. H.R. and Q.L. drafted the manuscript. All authors reviewed, discussed, and edited the final version of the manuscript. All the authors read and approved the final manuscript.




Publication History

Received: 26 October 2021

Accepted: 20 April 2022

Article published online:
27 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Lucchi M, Ricciardi R, Melfi F. et al. Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment. Eur J Cardiothorac Surg 2009; 35 (05) 812-816 discussion 816
    CrossrefPubMedGoogle Scholar
  • 2 Engels EA, Pfeiffer RM. Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies. Int J Cancer 2003; 105 (04) 546-551
    CrossrefPubMedGoogle Scholar
  • 3 Engels EA. Epidemiology of thymoma and associated malignancies. J Thorac Oncol 2010; 5 (10, Suppl 4): S260-S265
    CrossrefPubMedGoogle Scholar
  • 4 Müller-Hermelink HK, Marx A. Thymoma. Curr Opin Oncol 2000; 12 (05) 426-433
    CrossrefPubMedGoogle Scholar
  • 5 Christopoulos P, Fisch P. Acquired T-cell immunodeficiency in thymoma patients. Crit Rev Immunol 2016; 36 (04) 315-327
    CrossrefPubMedGoogle Scholar
  • 6 Souadjian JV, Enriquez P, Silverstein MN, Pépin JM. The spectrum of diseases associated with thymoma. Coincidence or syndrome?. Arch Intern Med 1974; 134 (02) 374-379
    CrossrefPubMedGoogle Scholar
  • 7 Katsura M, Kouso H, Shikada Y, Ushijima C, Momosaki S, Takeo S. Primary intrapulmonary thymoma. Gen Thorac Cardiovasc Surg 2015; 63 (01) 56-59
    CrossrefPubMedGoogle Scholar
  • 8 Singh SJ, Puhan MA, Andrianopoulos V. et al. An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir J 2014; 44 (06) 1447-1478
    CrossrefPubMedGoogle Scholar
  • 9 Miller RD, Hyatt RE. Evaluation of obstructing lesions of the trachea and larynx by flow-volume loops. Am Rev Respir Dis 1973; 108 (03) 475-481
    PubMedGoogle Scholar
  • 10 Shi YH, Zhu SW, Mao XZ. et al. Transcriptome profiling, molecular biological, and physiological studies reveal a major role for ethylene in cotton fiber cell elongation. Plant Cell 2006; 18 (03) 651-664
    CrossrefPubMedGoogle Scholar
  • 11 Roden AC, Yi ES, Jenkins SM. et al. Reproducibility of 3 histologic classifications and 3 staging systems for thymic epithelial neoplasms and its effect on prognosis. Am J Surg Pathol 2015; 39 (04) 427-441
    CrossrefPubMedGoogle Scholar
  • 12 Roden AC, Yi ES, Jenkins SM. et al. Modified Masaoka stage and size are independent prognostic predictors in thymoma and modified Masaoka stage is superior to histopathologic classifications. J Thorac Oncol 2015; 10 (04) 691-700
    CrossrefPubMedGoogle Scholar
  • 13 Pellegrino R, Viegi G, Brusasco V. et al. Interpretative strategies for lung function tests. Eur Respir J 2005; 26 (05) 948-968
    CrossrefPubMedGoogle Scholar
  • 14 Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC. Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax 2003; 58 (05) 388-393
    CrossrefPubMedGoogle Scholar
  • 15 Salas J, Montiel M, Jiménez E. et al. Angiogenic properties of adult human thymus fat. Cell Tissue Res 2009; 338 (02) 313-318
    CrossrefPubMedGoogle Scholar
  • 16 Silva C, Perris PD, Fernandez I. et al. Effects of high-fat diets from different sources on serum and thymus lipid profile: study in an experimental model. Endocr Metab Immune Disord Drug Targets 2014; 14 (02) 77-83
    CrossrefPubMedGoogle Scholar
  • 17 Osserman KE, Genkins G. Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients. Mt Sinai J Med 1971; 38 (06) 497-537
    PubMedGoogle Scholar
  • 18 Shamji F, Pearson FG, Todd TR, Ginsberg RJ, Ilves R, Cooper JD. Results of surgical treatment for thymoma. J Thorac Cardiovasc Surg 1984; 87 (01) 43-47
    CrossrefPubMedGoogle Scholar
  • 19 Masaoka A, Yamakawa Y, Niwa H. et al. Extended thymectomy for myasthenia gravis patients: a 20-year review. Ann Thorac Surg 1996; 62 (03) 853-859
    CrossrefPubMedGoogle Scholar
  • 20 Casey EM, Kiel PJ, Loehrer Sr PJ. Clinical management of thymoma patients. Hematol Oncol Clin North Am 2008; 22 (03) 457-473
    CrossrefPubMedGoogle Scholar
  • 21 Evoli A, Minisci C, Di Schino C. et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002; 59 (12) 1844-1850
    CrossrefPubMedGoogle Scholar