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CC BY-NC-ND 4.0 · Thorac Cardiovasc Surg 2023; 71(05): 425-431
DOI: 10.1055/s-0042-1749320
Original Thoracic

Analysis of Pulmonary Function in Thymoma Subjects: A 20-Year Retrospective Cohort Study

Hongyun Ruan
1   Beijing Chest Hospital, Beijing, China
,
Bin Liu
1   Beijing Chest Hospital, Beijing, China
,
Xinting Yang
1   Beijing Chest Hospital, Beijing, China
,
Xuehui Shang
1   Beijing Chest Hospital, Beijing, China
,
Qi Li 
1   Beijing Chest Hospital, Beijing, China
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Abstract

Background Thymoma is the most common tumor of the anterior mediastinum. However, the correlation between thymoma stage and pulmonary function was not assessed. Our objective in this study was to describe the pulmonary function in thymoma subjects stratified with different staging systems.

Methods A total of 143 subjects with a diagnosis of thymoma who underwent extended thymectomy for thymoma between January 2001 and December 2019 were reviewed retrospectively. All the subjects experienced pulmonary function tests (PFTs) using Master Screen PFT system and total respiratory resistance measurement.

Results We evaluated 143 subjects with a diagnosis of thymoma; the significant differences were observed in mean values of vital capacity, inspiratory volume (IC), total lung capacity (TLC), ratio of residual volume to total lung capacity (RV/TLC), forced vital capacity, forced expiratory volume in 1 second, ratio of forced expiratory volume in 1 second to forced vital capacity, peak expiratory flow, peak inspiratory flow, maximum ventilation volume, total airway resistance, and diffusing capacity for carbon monoxide (DLCO) across upper airway obstruction classification. PFTs of subjects with varying Masaoka stages are different. RV and RV/TLC of subjects in stages III and IV were higher than those of normal level, while DLCO of subjects in stage IV was lower than the normal level, and the mean level of IC showed significant difference between stage II and stage III.

Discussion The pulmonary function patterns of thymoma subjects significantly correlate with tumor location and size rather than clinical Masaoka stage.

Keywords

surgery - thymoma - pulmonary function tests - upper airway obstruction (UAO) - cohort study

Ethics Approval Statement

The study design complies with the Helsinki Research Ethics Statement and was approved by the Ethics Committee of Beijing Chest Hospital (2019) interim review no. (85).


Authors' Contribution

Q.L., X.S., H.R., B.L., and X.Y. designed and supervised the project. H.R. and B.L. collected the clinical samples. H.R. did postoperative patient follow-up. H.R gathered and processed the data. H.R. and B.L. performed the data analysis. H.R. and Q.L. drafted the manuscript. All authors reviewed, discussed, and edited the final version of the manuscript. All the authors read and approved the final manuscript.




Publication History

Received: 26 October 2021

Accepted: 20 April 2022

Article published online:
27 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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