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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(03): e440-e444
DOI: 10.1055/s-0042-1749390
Original Research

Normal Serum Levels of Otolin-1 in Patients with Meniere Disease in Remission

Anup Singh 
1   Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
,
Harsha Yadav 
1   Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
,
Hitesh Verma 
1   Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
,
Kapil Sikka 
1   Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
,
Ransi Ann Abraham 
2   Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
,
David Victor Kumar Irugu 
1   Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
› Institutsangaben Funding Funded by Research Section, All India Institute of Medical Sciences, New Delhi (Project code: A-643, No.F.8-643/A-643/2018/RS, Dated 15-11-2018). Research grant approval letter has been uploaded with the rest of the files on author's page.
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Abstract

Introduction Degenerative changes in the otolithic organs have been theorized to be caused by the mechanical obstruction to endolymphatic flow, possibly resulting in endolymphatic hydrops (ELH). Otolin-1 is an otoconial matrix protein that crosses the blood labyrinth barrier and has been found in the serum of healthy and diseased patients.

Objective To measure the serum levels of Otolin-1 in Meniere disease (MD) patients and compared them with the healthy individuals.

Methods This pilot, cross-sectional study was performed at our tertiary care referral center to compare the serum Otolin-1 levels of healthy individuals with those of MD patients. The blood samples were obtained during patients' visit to the vertigo clinic following remission of an acute episode. The data was analyzed using the Stata/SE version 12.0 (StataCorp. College Station, TX, USA). Comparison between the serum Otolin-1 levels in the two groups was performed using the unpaired t-test. A p-value of 0.05 was considered to be statistically significant.

Results The participants were divided into two groups, with 31 MD patients, and 30 age and gender-matched members of the control group. The serum levels of Otolin-1 in MD patients (247.6, ± 44.2 pg/ml) were not found to be significantly different from those of the control group (236.2, ± 43.5 pg/ml) (p = 0.31).

Conclusion The current study reveals that the serum levels of Otolin-1 are not significantly different between the patients with MD in the interictal phase and the control group's healthy ones.

Keywords

Meniere disease - otolithic membrane - endolymph drainage - biomarkers

Disclosures

The corresponding author has received research grant from the institutional research committee. Rest of the authors have no conflicts of interest to declare. To keep the anonymity, rest of the details are mentioned in title page (following double blind policy of the journal).


Ethical Considerations

The ethical clearance was obtained from the institutional Ethical committee (Ref No. - IEC 506/05.10.18, RP-14/2018; dated 18.10.2018) prior to commencing the study. The same has been uploaded with the rest of the files on author's page.


Data Availability Statement

The study related data are available as supplementary file-1 uploaded with the rest of the files.


Author Contribution

David Victor Kumar Irugu – Main researcher of this study, conception and design of the study, acquisition, analysis, and interpretation of data.


Anup Singh – Acquisition, analysis, and interpretation of data, drafting the article, final approval of the version to be published.


Harsha Yadav – Acquisition, analysis, and interpretation of data, drafting the article, final approval of the version to be published.


Hitesh Verma – Analysis and interpretation of data, drafting the article, final approval of the version to be published.


Kapil Sikka – Analysis and interpretation of data, drafting the article, final approval of the version to be published.


Ransi Ann Abraham – Analysis and interpretation of data, drafting the article, final approval of the version to be published.




Publikationsverlauf

Eingereicht: 18. September 2021

Angenommen: 17. April 2022

Artikel online veröffentlicht:
04. August 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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