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DOI: 10.1055/s-0042-1749451
Long-Term Assessment of Bone Regeneration in Nonunion Fractures Treated with Compression-Resistant Matrix and Recombinant Human Bone Morphogenetic Protein-2 in Dogs
Funding Funded by the Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis. 2019-55-R![](https://www.thieme-connect.de/media/10.1055-s-00035023/202301/lookinside/thumbnails/10-1055-s-0042-1749451_210096-1.jpg)
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Abstract
Objective The aim of this study was to assess bone density, bone architecture and clinical function of canine nonunion distal appendicular long bone fractures with a defect treated with fixation, compression-resistant matrix and recombinant human bone morphogenetic protein-2 (rhBMP-2).
Study Design Prospective cohort study with dogs at least 1-year post treatment. Computed tomography was performed and quantitative measurements from previous fracture sites were compared with measurements from contralateral limbs. Subjective evaluation included gait assessment and palpation.
Results Six patients met the inclusion criteria. The rhBMP-2 treated bone exhibited higher density at the periphery and lower density in the centre, similar to the contralateral limb. All patients were weight bearing on the treated limb and all fractures were healed.
Conclusion The rhBMP-2-treated bone underwent restoration of normal architecture and density. Acceptable limb function was present in all patients. The results of this study can serve as a basis for long-term response in treating nonunion fractures in veterinary patients.
Keywords
Bone morphogenetic protein 2 - rhBMP-2 - nonunion fracture - compression-resistant matrix - bone regenerationAuthors' Contributions
All authors contributed to the development of study design. ASK performed the surgery on all of the patients. AC and ASK evaluated the clinical cases. MS, AC, BF, ASK and T.G contributed to the acquisition of data, data analysis and interpretation. AC and BF developed the main manuscript and all the authors contributed to the review and approval of the manuscript prior to submission.
Publication History
Received: 27 August 2021
Accepted: 13 April 2022
Article published online:
27 June 2022
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