Vet Comp Orthop Traumatol 2023; 36(01): 29-38
DOI: 10.1055/s-0042-1749451
Clinical Communication

Long-Term Assessment of Bone Regeneration in Nonunion Fractures Treated with Compression-Resistant Matrix and Recombinant Human Bone Morphogenetic Protein-2 in Dogs

Andrea Castilla
1   Veterinary Medical Teaching Hospital, Davis, University of California, California, United States
,
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
,
Mathieu Spriet
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
,
Tanya C. Garcia
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
,
Boaz Arzi
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
3   Veterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, California, United States
,
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
,
Amy S. Kapatkin
2   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States
› Author Affiliations
Funding Funded by the Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis. 2019-55-R
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Abstract

Objective The aim of this study was to assess bone density, bone architecture and clinical function of canine nonunion distal appendicular long bone fractures with a defect treated with fixation, compression-resistant matrix and recombinant human bone morphogenetic protein-2 (rhBMP-2).

Study Design Prospective cohort study with dogs at least 1-year post treatment. Computed tomography was performed and quantitative measurements from previous fracture sites were compared with measurements from contralateral limbs. Subjective evaluation included gait assessment and palpation.

Results Six patients met the inclusion criteria. The rhBMP-2 treated bone exhibited higher density at the periphery and lower density in the centre, similar to the contralateral limb. All patients were weight bearing on the treated limb and all fractures were healed.

Conclusion The rhBMP-2-treated bone underwent restoration of normal architecture and density. Acceptable limb function was present in all patients. The results of this study can serve as a basis for long-term response in treating nonunion fractures in veterinary patients.

Authors' Contributions

All authors contributed to the development of study design. ASK performed the surgery on all of the patients. AC and ASK evaluated the clinical cases. MS, AC, BF, ASK and T.G contributed to the acquisition of data, data analysis and interpretation. AC and BF developed the main manuscript and all the authors contributed to the review and approval of the manuscript prior to submission.




Publication History

Received: 27 August 2021

Accepted: 13 April 2022

Article published online:
27 June 2022

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