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CC BY-NC-ND 4.0 · World J Nucl Med 2022; 21(02): 112-119
DOI: 10.1055/s-0042-1750332
Original Article

The Diagnostic Accuracy of 18F-FGD-PET/CT for Cancer of the Gallbladder: A Retrospective Study

Stephanos Pericleous
1   Department of HPB Surgery, Academic Department of Surgery, Royal Marsden Hospital, London, United Kingdom
,
Sophie L. F. Doran
1   Department of HPB Surgery, Academic Department of Surgery, Royal Marsden Hospital, London, United Kingdom
,
Andrew Wotherspoon
2   Department of Histopathology, Royal Marsden Hospital, London, United Kingdom
,
Monica Terlizzo
2   Department of Histopathology, Royal Marsden Hospital, London, United Kingdom
,
Angela Riddell
3   Department of Radiology and Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom
,
Gina Brown
3   Department of Radiology and Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom
,
Joshua Shur
3   Department of Radiology and Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom
,
Sue Chua
3   Department of Radiology and Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom
,
Nabil Hujairi
3   Department of Radiology and Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom
,
Nicos Middleton
4   School of Health Sciences, Cyprus University of Technology, Limassol, Cyprus
,
David Cunningham
5   Department of Oncology, Royal Marsden Hospital, London, United Kingdom
,
Sacheen Kumar
6   Department of Surgery, Academic Department of Surgery, Royal Marsden Hospital, London, United Kingdom
,
Ricky H. Bhogal
1   Department of HPB Surgery, Academic Department of Surgery, Royal Marsden Hospital, London, United Kingdom
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Abstract

Background Gallbladder cancer has a poor prognosis and imaging can have variable diagnostic accuracy. We assessed the ability of preoperative 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) imaging to predict a postoperative histological diagnosis of gallbladder cancer.

Method A retrospective analysis was undertaken in a cohort of patients, who had suspected gallbladder cancer on cross-sectional imaging and that underwent preoperative FDG-PET/CT scan. The discriminatory power of FDG-PET/CT was determined in receiver operator characteristic (ROC) analysis and diagnostic accuracy parameters were estimated at different thresholds of maximum standard unit value (SUVmax).

Results Twenty-two patients were included in the study; 7 had malignant and 15 benign diagnoses. There was no statistically significant difference between the measured SUVmax between the two groups (p = 0.71). With an area under the curve of 0.486, the ROC curve did not indicate any discriminatory power of FDG-PET/CT at any potential threshold of SUVmax.

Conclusion This study indicates that the diagnosis of primary gallbladder cancer cannot be accurately confirmed with FDG PET/CT scanning.

Keywords

gallbladder - FDG - PET - CT - cancer - thickening - cholecystitis - diagnostic accuracy

Authors' Contributions

SP and RHB conceptualized the manuscript. SP and SLFD were involved in data curation. SP and RHB were involved in methodology. SP and NM did formal analysis. AW, MT, AR, GB, JS, SC, and NH validated the data. SP, SLFD, and RHB were involved in write up of original data. SP, AW, MT, AR, GB, JS, SC, NH, DC, SK, and RHB were involved in write-up, review, and editing.




Publication History

Article published online:
19 July 2022

© 2022. World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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