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CC BY-NC-ND 4.0 · Asian J Neurosurg 2022; 17(02): 286-301
DOI: 10.1055/s-0042-1750389
Case Report

Remote Supratentorial Recurrent Medulloblastoma: Case Study and Literature Review

Asimina Dominari
1   Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
,
Elias Antoniades
2   Department of Neurosurgery, AHEPA University Hospital, Thessaloniki, Greece
,
Antonio Capiccelo
3   Department of Radiotherapy, AHEPA University Hospital, Thessaloniki, Greece
,
Emmanuil Hatzipantelis
4   Pediatric Oncology Unit, 2nd Pediatric Department of Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
,
Nikolaos Foroglou
1   Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
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Abstract

Medulloblastomas comprise 10% of pediatric brain tumors. Subfrontal recurrence is uncommon and has been associated with prone positioning, inadequate irradiation of the cribriform plate area, and hydrocephalus management. We discuss the case report of an 8-year-old boy with subfrontal medulloblastoma recurrence. The literature was reviewed using terms such as “medulloblastoma,” “subfrontal recurrence,” and “child.” Forty-eight cases of subfrontal medulloblastoma recurrence were identified. The mean age at presentation was 12.3 years. Gross total resection was achieved in 44%, most patients received adjuvant radiation therapy, and approximately 25% received chemotherapy. The mean recurrence interval was 2.6 years. The mean number of recurrences per patient was 1.2 and the mean survival period was 3.3 years. Even in the case of meticulous resection and sufficient irradiation, recurrences may still occur. Our case indicates that resection of the recurrent lesion and repeat irradiation may benefit patients with satisfactory short-term results.

Keywords

subfrontal - recurrence - medulloblastoma - child - predisposing factors - treatment

Note

This paper was presented at the 27th Congress of the European Society of Pediatric Neurosurgery, held virtually at Athens, Greece, on April 25–28, 2021.




Publication History

Article published online:
24 August 2022

© 2022. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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