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CC BY 4.0 · Eur J Dent 2023; 17(02): 492-496
DOI: 10.1055/s-0042-1750776
Original Article

In Silico Study of Liquid Smoke Rice Husk against COVID-19

Ira Arundina
1   Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Neni Frimayanti
2   Sekolah Tinggi Ilmu Farmasi, Pekanbaru, Riau, Indonesia
,
Meircurius D. C. Surboyo 
3   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Theresia I. Budhy
4   Department of Oral Pathology and Maxillofacial, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Benni Iskandar 
2   Sekolah Tinggi Ilmu Farmasi, Pekanbaru, Riau, Indonesia
5   School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
,
Arya Pradana
6   Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Tytania Rahmaputry
6   Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
› Author Affiliations Funding This work is supported by Ministry of Higher Education Republic of Indonesia in the Schema Penelitian Dasar (PD) in 2021 with grant number: 310/UN3.15/PT/2021.
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Abstract

Objectives Liquid smoke rice husk has been researched and proved to consist of antibacterial, analgesic, anti-inflammatory, and growth factor stimulatory properties. By these complex properties, the liquid smoke rice hull is able to purpose as a novel coronavirus disease 2019 (COVID-19) inhibitor. The research was conducted to analyze the role of the dominant compound in rice husk liquid smoke against one of the main proteases in complex with inhibitor N3 of COVID-19 and 6LU7 protein data bank (PDB) ID.

Material and Methods The Molecular Operating Environment (MOE) 2020.0901 (Chemical computing group) was used to analyzed the interaction. The molecular structure test, including phenol, mequinol, 2-methoxy-phenol, 6-octadecenoic acid, oleic acid, 9-cctadecenoic acid, was chosen. The lopinavir as positive control and 6LU7 as COVID-19 protein were chosen. All the protein analyses were conducted using docking molecular.

Result The phenol, 2-methoxy-phenol, mequinol and 9-octadecenoic acid have higher binding free energy that causes difficult to bind to the active site of protein 6LU7 (−3.4758, −3.5509, −3.6845, and −5.0173 kcal/mol, respectively). The minor component of liquid smoke, such as 6-octadecenoic acid and oleic acid, has the binding free energy (−5,5327 and −5,4208 kcal/mol) and more factor of binding presumably as active COVID-19 inhibitor.

Conclusion The liquid smoke rice husk has active component like 6-octadecenoic acid and oleic acid are presumably as active COVID-19 inhibitor.

Keywords

liquid smoke - rice husk - coronavirus disease 2019 - infectious disease - in silico


Publication History

Article published online:
08 September 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Indraswari ADW, Aziz A, Surboyo MDC. The knowledge, attitude, and behavior of hospitalized patients' families in the effort to prevent COVID-19. J Health Allied Sci NU 2022; 12 (02) 113-118 DOI: 10.1055/s-0041-1736271.
    Article in Thieme ConnectGoogle Scholar
  • 2 Achmadi NK, Setiawan Y, Ayu Purwati A. An overview knowledge and usage of herbal medicines during the COVID-19 pandemic by students of Poltekkes Kemenkes Jakarta II. J Teknol Seni Kesehatan 2021; 12 (02) 106-114
    CrossrefGoogle Scholar
  • 3 Chaachouay N, Douira A, Zidane L. COVID-19, prevention and treatment with herbal medicine in the herbal markets of Salé Prefecture, North-Western Morocco. Eur J Integr Med 2021; 42: 101285
    CrossrefPubMedGoogle Scholar
  • 4 Zafar S. Biomass Pyrolysis Process. Accessed May 20, 2022 at: https://www.bioenergyconsult.com/biomass-pyrolysis-process/
    Google Scholar
  • 5 Arundina I, Diyatri I, Dwi M, Surboyo C. The component analysis of liquid smoke from rice hulls and its toxicity test on baby hamster kidney cells. J Pharm Res 2021; 9 (01) 78-87
    Google Scholar
  • 6 Surboyo MDC, Arundina I, Rahayu RP. Increase of collagen in diabetes-related traumatic ulcers after the application of liquid smoke coconut shell. Dent J 2017; 50 (02) 71
    CrossrefGoogle Scholar
  • 7 Surboyo MDC, Arundina I, Rahayu RP, Mansur D, Bramantoro T. Potential of distilled liquid smoke derived from coconut (Cocos nucifera L) shell for traumatic ulcer healing in diabetic rats. Eur J Dent 2019; 13 (02) 271-279
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Faisal M, Gani A, Mulana F. Preliminary assessment of the utilization of durian peel liquid smoke as a natural preservative for mackerel. F1000 Res 2019; 8: 240
    CrossrefPubMedGoogle Scholar
  • 9 Swastawati F, Agustini TW, Darmanto YS, Dewi EN. Liquid smoke performance of Lamtoro Wood and Corn Cob. J Coast Develop 2007; 10 (03) 189-196
    Google Scholar
  • 10 Triastuti WE, Budhi PA, Agustiani E, Hidayat RA, Retnoningsih R, Nisa' AA. Caracterization of liquid smoke bamboo waste with pyrolysis method. IPTEK J Proceed Series 2019; 3: 114-117
    CrossrefGoogle Scholar
  • 11 Handojo L, Indarto A. Cocoa bean skin waste as potential raw material for liquid smoke production. Environ Technol 2020; 41 (08) 1044-1053
    CrossrefPubMedGoogle Scholar
  • 12 Budhy TI, Arundina I, Surboyo MDC, Halimah AN. The effects of rice husk liquid smoke in porphyromonas gingivalis-induced periodontitis. Eur J Dent 2021; 15 (04) 653-659
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Arundina I, Diyatri I, Kusumaningsih T, Surboyo MDC, Monica E, Afanda NM. The role of rice hull liquid smoke in the traumatic ulcer healing. Eur J Dent 2020; 15 (01) 33-38
    PubMedGoogle Scholar
  • 14 Arundina I, Diyatri I, Surboyo MDC, Monica E, Afanda NM. Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke. J Taibah Univ Med Sci 2021; 16 (03) 431-439
    PubMedGoogle Scholar
  • 15 Surboyo MDC, Ernawati DS, Arundina I. et al. The potential of liquid smoke as an oral ulcer remedies: a proposed mechanism based on systematic review. J Pharm Pharmacogn Res 2021; 9 (06) 905-920
    CrossrefGoogle Scholar
  • 16 Surboyo MDC, Mahdani FY, Ayuningtyas NF. et al. The cytotoxicity, antiinflammation, anti nociceptive and oral ulcer healing properties of coconut shell liquid smoke. J Herbmed Pharmacol 2021; 10 (04) 459-467
    CrossrefGoogle Scholar
  • 17 Yang JY, Kang MY, Nam SH, Friedman M. Antidiabetic effects of rice hull smoke extract in alloxan-induced diabetic mice. J Agric Food Chem 2012; 60 (01) 87-94
    CrossrefPubMedGoogle Scholar
  • 18 Yang JY, Moon E, Nam SH, Friedman M. Antidiabetic effects of rice hull smoke extract on glucose-regulating mechanism in type 2 diabetic mice. J Agric Food Chem 2012; 60 (30) 7442-7449
    CrossrefPubMedGoogle Scholar
  • 19 Tarawan VM, Mantilidewi KI, Dhini IM, Radhiyanti PT, Sutedja E. Coconut shell liquid smoke promotes burn wound healing. J Evid Based Complementary Altern Med 2017; 22 (03) 436-440
    CrossrefPubMedGoogle Scholar
  • 20 Surboyo MDC, Tantiana T, Arundina I. Analgesic effect of coconut shell (Cocos nucifera L) liquid smoke on mice. Dent J 2012; 45 (03) 156-160
    CrossrefGoogle Scholar
  • 21 Arundina I, Diyatri I, Surboyo MDC, Halimah AN, Chusnurrafi FI. The antibacterial effect of liquid smoke rice hull on porphyromonas gingivalis and its proliferative effects on osteoblast as periodontitis remedies: an invitro study. Int J Pharmaceut Res 2020; 12 (03) 3466-3471
    Google Scholar
  • 22 Arundina I, Tantiana T, Diyatri I, Surboyo MDC, Adityasari R. Acute toxicity of liquid smoke of rice hull (Oryza sativa) on mice (Mus musculus). J Int Dent Med Res 2020; 13 (01) 91-96
    Google Scholar
  • 23 Ayudiarti DL, Sari RN. Liquid smoke and its applications for fisheries products. Ayudiarti 2010; 5 (03) 102-108
    Google Scholar
  • 24 CT N, Sekhar Chatterjee N, CG J. et al. Source-dependent compositional changes in coconut flavoured liquid smoke and its application in traditional Indian smoked fishery products. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2020; 37 (10) 1610-1620
    CrossrefPubMedGoogle Scholar
  • 25 Šimko P. Factors affecting elimination of polycyclic aromatic hydrocarbons from smoked meat foods and liquid smoke flavorings. Mol Nutr Food Res 2005; 49 (07) 637-647
    CrossrefPubMedGoogle Scholar
  • 26 Frimayanti N, Yam ML, Lee HB, Othman R, Zain SM, Rahman NA. Validation of quantitative structure-activity relationship (QSAR) model for photosensitizer activity prediction. Int J Mol Sci 2011; 12 (12) 8626-8644
    CrossrefPubMedGoogle Scholar
  • 27 Keretsu S, Bhujbal SP, Cho SJ. Rational approach toward COVID-19 main protease inhibitors via molecular docking, molecular dynamics simulation and free energy calculation. Sci Rep 2020; 10 (01) 17716
    CrossrefPubMedGoogle Scholar
  • 28 Nutho B, Mahalapbutr P, Hengphasatporn K. et al. Why are lopinavir and ritonavir effective against the newly emerged coronavirus 2019? Atomistic insights into the inhibitory mechanisms. Biochemistry 2020; 59 (18) 1769-1779
    CrossrefPubMedGoogle Scholar
  • 29 Vargas M, Servillo G, Einav S. Lopinavir/ritonavir for the treatment of SARS, MERS and COVID-19: a systematic review. Eur Rev Med Pharmacol Sci 2020; 24 (16) 8592-8605
    PubMedGoogle Scholar