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CC BY-NC-ND 4.0 · Asian J Neurosurg 2022; 17(02): 199-208
DOI: 10.1055/s-0042-1750784
Special Report

Patients with Invasive Tumors and eNOS Gene Polymorphisms with Subarachnoid Hemorrhage Tend to Have Poorer Prognosis

Hardik Lalit Siroya
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Bhagavatula Indira Devi
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Prasanthi Aripirala
2   Department of Pediatrics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Shruthi Shimoga Ramesh
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Dhananjaya Ishwar Bhat
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Dhaval Prem Shukla
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Subhash Kanti Konar
1   Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
,
Rita Christopher
3   Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India
› Institutsangaben Funding We thank the Indian Council of Medical Research for funding.
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Abstract

Context Endothelial nitric oxide synthase (eNOS) gene polymorphisms are found to predict predisposition to aneurysmal rupture and development of vasospasm in a patient of subarachnoid hemorrhage (SAH). eNOS gene polymorphisms are also found to predict invasiveness of malignant cells. Studies are not available in literature to describe the effect of eNOS gene polymorphisms and correlation between aneurysm and carcinoma. This study aims to investigate whether positive cancer history influences clinical outcome following SAH and eNOS gene polymorphisms.

Materials and Methods The eNOS gene polymorphisms were analyzed in seven consecutive patients (mean age, 52.28 ± 20 years) with a diagnosis of invasive systemic tumors from 2011 to 2017. The eNOS 4a/4b eNOS -786T> eNOS894G > T polymorphisms of the eNOS gene were determined by polymerase chain reaction and restriction fragment length polymorphism.

Results Seven patients of aneurysmal SAH in association with malignancies were studied for eNOS polymorphisms expression and outcome. Three patients had carcinoma cervix: one patient of carcinoma breast and one each of transitional cell carcinoma of urinary bladder, spindle cell carcinoma of left kidney, and untreated patient of atypical pituitary (adenoma). A genotype study of eNOS gene polymorphisms in these patients shows common polymorphisms are involved in the determination of disease progression in malignancies and aneurysmal SAH.

Conclusion Patients who expressed 4ab, eNOS -786T > TT/CC/TC, eNOS894G > T GG/GT polymorphisms did better than patients who expressed only 4bb, though both were associated with poor prognosis.

Keywords

invasive malignancy/tumors - eNOS gene polymorphisms - intracranial aneurysms


Publikationsverlauf

Artikel online veröffentlicht:
24. August 2022

© 2022. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Lee T-H, Huang S-C, Su T-M, Yang K-Y, Rau C-S. Multiple cerebral aneurysms and brain metastasis from primary cardiac myxosarcoma: a case report and literature review. Chang Gung Med J 2011; 34 (03) 315-319
    PubMedGoogle Scholar
  • 2 Nomura R, Yoshida D, Kim K, Kobayashi S, Teramoto A. Intracerebral hemorrhage caused by a neoplastic aneurysm from pleomorphic lung carcinoma. Neurol Med Chir (Tokyo) 2009; 49 (01) 33-36
    CrossrefPubMedGoogle Scholar
  • 3 Cheng WY, Shen CC. Minimally invasive approaches to treat simultaneous occurrence of glioblastoma multiforme and intracranial aneurysm – case report. Minim Invasive Neurosurg 2004; 47 (03) 181-185
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 4 Cheon KT, Choi KH, Lee HB, Park SK, Rhee YK, Lee YC. Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with lung cancer. Lung 2000; 178 (06) 351-360
    CrossrefPubMedGoogle Scholar
  • 5 Ivanović BA, Tadić M, Vraneš M, Orbović B. Cerebral aneurysm associated with cardiac myxoma: case report. Bosn J Basic Med Sci 2011; 11 (01) 65-68
    CrossrefPubMedGoogle Scholar
  • 6 Spetzger U, Mull M, Sure U, Gilsbach J. Subarachnoid and intraventricular hemorrhage caused by hypernephroma metastasis, accompanied by innocent bilateral posterior communicating artery aneurysms. Surg Neurol 1995; 44 (03) 275-278
    CrossrefPubMedGoogle Scholar
  • 7 Yamamoto F, Maruiwa M, Kanetani K, Matsuo H, Shigemori M, Kuramoto S. [Coexistence of multiple metastatic brain tumors from thyroid carcinoma and cerebral aneurysms]. No Shinkei Geka 1990; 18 (04) 361-365
    PubMedGoogle Scholar
  • 8 Matsko DE, Babaĭtsev AV, Glukhovets BI, Litvak EA. [Intracranial oncogenic aneurysm]. Arkh Patol 1989; 51 (02) 72-75
    PubMedGoogle Scholar
  • 9 Honda M, Kamada K, Nakata Y, Harada T, Iwanaga H, Tsukamoto M. [The association of cerebral aneurysm with malignant brain tumor–report of a case (author's transl)]. No Shinkei Geka 1980; 8 (11) 1065-1070
    PubMedGoogle Scholar
  • 10 Pant B, Arita K, Kurisu K, Tominaga A, Eguchi K, Uozumi T. Incidence of intracranial aneurysm associated with pituitary adenoma. Neurosurg Rev 1997; 20 (01) 13-17
    CrossrefPubMedGoogle Scholar
  • 11 Javalkar V, Guthikonda B, Vannemreddy P, Nanda A. Association of meningioma and intracranial aneurysm: report of five cases and review of literature. Neurol India 2009; 57 (06) 772-776
    CrossrefPubMedGoogle Scholar
  • 12 Shibahara I, Watanabe T, Ezura M. et al. Clinical features of subarachnoid hemorrhage in patients with positive cancer history. J Neurooncol 2016; 128 (01) 129-136
    CrossrefPubMedGoogle Scholar
  • 13 Maheshwari A, Gupta S, Wuntkal R, Kulkarni Y, Tongaonkar HM. Brain metastasis from cervical carcinoma–a case report. J Medscape Gen Med 2005
    Google Scholar
  • 14 Duarte FHG, Machado MC, Lima JR, Salgado LR. Severe hyperprolactinemia associated with internal carotid artery aneurysm: differential diagnosis between prolactinoma and hypothalamic-pituitary disconnection. Arq Bras Endocrinol Metabol 2008; 52 (07) 1189-1193
    CrossrefPubMedGoogle Scholar
  • 15 Wadasadawala T, Gupta S, Bagul V, Patil N. Brain metastases from breast cancer: management approach. J Cancer Res Ther 2007; 3 (03) 157-165
    CrossrefPubMedGoogle Scholar
  • 16 Koppelmans V, Schagen SB, Poels MMF. et al. Incidental findings on brain magnetic resonance imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. Eur J Cancer 2011; 47 (17) 2531-2536
    CrossrefPubMedGoogle Scholar
  • 17 Alexander S, Poloyac S, Hoffman L. et al. Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage. Biol Res Nurs 2009; 11 (01) 42-52
    CrossrefPubMedGoogle Scholar
  • 18 Gao X, Wang J, Wang W, Wang M, Zhang J. eNOS genetic polymorphisms and cancer risk: a meta-analysis and a case-control study of breast cancer. Medicine (Baltimore) 2015; 94 (26) e972
    CrossrefPubMedGoogle Scholar
  • 19 Khurana VG, Sohni YR, Mangrum WI. et al. Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. J Cereb Blood Flow Metab 2004; 24 (03) 291-297
    CrossrefPubMedGoogle Scholar
  • 20 Ko NU, Rajendran P, Kim H. et al. Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008; 39 (04) 1103-1108
    CrossrefPubMedGoogle Scholar
  • 21 Krischek B, Kasuya H, Akagawa H. et al. Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. J Neurosurg 2006; 105 (05) 717-722
    CrossrefPubMedGoogle Scholar
  • 22 Li P, Ma LT, Zhang XZ, Gong J, Mo XH. [Risk of cerebral vasospasm following subarachnoid hemorrhage is associated with endothelial nitric oxide synthase gene polymorphism]. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29 (02) 280-283
    PubMedGoogle Scholar
  • 23 McColgan P, Thant KZ, Sharma P. The genetics of sporadic ruptured and unruptured intracranial aneurysms: a genetic meta-analysis of 8 genes and 13 polymorphisms in approximately 20,000 individuals. J Neurosurg 2010; 112 (04) 714-721
    CrossrefPubMedGoogle Scholar
  • 24 Murthy SB, Shastri A, Merkler AE. et al. Intracerebral hemorrhage outcomes in patients with systemic cancer. J Stroke Cerebrovasc Dis 2016; 25 (12) 2918-2924
    CrossrefPubMedGoogle Scholar
  • 25 Navi BB, Reichman JS, Berlin D. et al. Intracerebral and subarachnoid hemorrhage in patients with cancer. Neurology 2010; 74 (06) 494-501
    CrossrefPubMedGoogle Scholar
  • 26 Navi BB, Reiner AS, Kamel H. et al. Association between incident cancer and subsequent stroke. Ann Neurol 2015; 77 (02) 291-300
    CrossrefPubMedGoogle Scholar
  • 27 Ozüm U, Bolat N, Gül E, Özdemir O. Endothelial nitric oxide synthase gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage. Acta Neurochir (Wien) 2008; 150 (01) 57-61 , discussion 62
    CrossrefPubMedGoogle Scholar
  • 28 Paschoal EHA, Yamaki VN, Teixeira RKC. et al. Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis. Neurosurg Rev 2018; 41 (01) 87-94
    CrossrefPubMedGoogle Scholar
  • 29 Polat F, Diler SB, Azazi İ, Öden A. T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in bladder cancer cases. Asian Pac J Cancer Prev 2015; 16 (06) 2199-2202
    CrossrefPubMedGoogle Scholar
  • 30 Rosalind Lai PM, Du R. Role of genetic polymorphisms in predicting delayed cerebral ischemia and radiographic vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis. World Neurosurg 2015; 84 (04) 933-41.e2
    CrossrefPubMedGoogle Scholar
  • 31 Staalsø JM, Edsen T, Kotinis A, Romner B, Springborg JB, Olsen NV. Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage. J Neurosurg 2014; 121 (03) 587-592
    CrossrefPubMedGoogle Scholar
  • 32 Starke RM, Kim GH, Komotar RJ. et al. Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab 2008; 28 (06) 1204-1211
    CrossrefPubMedGoogle Scholar
  • 33 Velander AJ, DeAngelis LM, Navi BB. Intracranial hemorrhage in patients with cancer. Curr Atheroscler Rep 2012; 14 (04) 373-381
    CrossrefPubMedGoogle Scholar
  • 34 Verim L, Toptas B, Ozkan NE. et al. Possible relation between the NOS3 gene GLU298ASP polymorphism and bladder cancer in Turkey. Asian Pac J Cancer Prev 2013; 14 (02) 665-668
    CrossrefPubMedGoogle Scholar
  • 35 Wu X, Wang Z-F, Xu Y, Ren R, Heng B-L, Su Z-X. Association between three eNOS polymorphisms and cancer risk: a meta-analysis. Asian Pac J Cancer Prev 2014; 15 (13) 5317-5324
    CrossrefPubMedGoogle Scholar
  • 36 Zhang L, Chen LM, Wang MN. et al. The G894t, T-786c and 4b/a polymorphisms in Enos gene and cancer risk: a meta-analysis. J Evid Based Med 2014; 7 (04) 263-269
    CrossrefPubMedGoogle Scholar
  • 37 Khalkhali-Ellis Z, Hendrix MJC. Nitric oxide regulation of Maspin expression in normal mammary epithelial and breast cancer cells. Am J Pathol 2003; 162 (05) 1411-1417
    CrossrefPubMedGoogle Scholar
  • 38 Schneider BP, Radovich M, Sledge GW. et al. Association of polymorphisms of angiogenesis genes with breast cancer. Breast Cancer Res Treat 2008; 111 (01) 157-163
    CrossrefPubMedGoogle Scholar
  • 39 Yeh C-C, Santella RM, Hsieh L-L, Sung F-C, Tang R. An intron 4 VNTR polymorphism of the endothelial nitric oxide synthase gene is associated with early-onset colorectal cancer. Int J Cancer 2009; 124 (07) 1565-1571
    CrossrefPubMedGoogle Scholar
  • 40 Khurana VG, Meissner I, Sohni YR. et al. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 2005; 102 (03) 526-531
    CrossrefPubMedGoogle Scholar