Synthesis of Nitrogen Heterocycles by a C–C Cross-Coupling/Cycloisomerization Strategy

Peter Langer

doi:10.1055/s-0042-1751352

Synlett, Inhaltsverzeichnis

Synlett 2022; 33(17): 1707-1715
DOI: 10.1055/s-0042-1751352

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Synthesis of Nitrogen Heterocycles by a C–C Cross-Coupling/Cycloisomerization Strategy

Peter Langer ∗

^aInstitut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany URL: http://www.langer.chemie.uni-rostock.de/

^bLeibniz-Institut für Katalyse an der Universität Rostock e. V., Albert-Einstein-Str. 29a, 18059 Rostock, Germany

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Abstract

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Abstract

The present article presents a personalized Account on the synthesis of nitrogen heterocycles by combination of regioselective Pd-catalyzed cross-coupling reactions of polyhalogenated heterocycles, i.e., Suzuki–Miyaura and Sonogashira reactions, with acid-mediated cycloisomerization reactions. In many cases, the products constitute new heterocyclic core structures and show interesting optical and electronic properties.

1 Introduction

2 Acridines

3 Phenathridines

4 Azapyrenes

5 Thienoquinolines

6 Pyrrolonaphthyridines

7 6-Aza-ullazines

8 Conclusions

Key words

catalysis - cross-coupling - cycloisomerization - heterocycles - palladium - regioselectivity

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Referenzen

References

For reviews of regioselective palladium(0)-catalyzed cross-coupling reactions, see:

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