Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy

Nasrin Jahan; Inul Ansary

doi:10.1055/s-0042-1751453

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CC BY 4.0 · SynOpen 2023; 07(02): 209-242
DOI: 10.1055/s-0042-1751453

review

Virtual Collection Click Chemistry and Drug Discovery

Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy

Nasrin Jahan

,

Inul Ansary ∗

Abstract

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Abstract

This review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer activities, and more. Thus, their syntheses and utilization are essential for both synthetic organic and medicinal chemists.

Key words

macrocycles - ring-closing metathesis - antiviral - antifungal - anticancer - antibiotic

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References

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