Boryl Radical-Promoted Deoxygenative Alkylation of Benzyl Acetates

Abstract

Deoxygenative alkylation of benzyl alcohols was realized by using acetate as the alcohol activation group. The C–O bond homolysis is achieved by a boryl radical-promoted β-scission process. The strategy is amenable to a variety of benzyl alcohols, including primary, secondary, and more challenging tertiary alcohols. The synthetic practicability was demonstrated by a gram-scale one-pot reaction.

Key words

deoxygenative alkylation - C–O bond activation - reduction - boryl radical

Publication History

Received: 23 March 2023

Accepted after revision: 12 May 2023

Article published online:
27 June 2023

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