Synlett 2024; 35(10): 1089-1100
DOI: 10.1055/s-0042-1751520
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Thieme Chemistry Journals Awardees 2023

Dearomatization of α-Unsubstituted β-Naphthols

Ying Li
,
Kongling Feng
,
Ruinan Zhao
,
Cuiju Zhu
,
Hao Xu
We are grateful for financial support from the National Natural Science Foundation of China (21801087), the Fundamental Research Funds for the Central Universities, and the Central China Normal University (CCNU19QN064).


Abstract

This Account summarizes the highly appealing dearomatization reactions of β-naphthols for the synthesis of highly functionalized, three-dimensional structures starting with simple planar aromatic compounds. The reactions are categorized mainly from the viewpoint of the construction of carbon–hydrogen, carbon–carbon, and carbon–hetero bonds (C–N/O, C–Cl, C–F) at the α-position of β-naphthols. The dearomatized products play an important role in organic synthesis and materials science.

1 Introduction

2 Construction of Carbon–Hydrogen Bonds at the α-Position of β-Naphthols

3 Construction of Carbon–Carbon Bonds at the α-Position of β-Naphthols

4 Construction of Carbon–Nitrogen/Oxygen Double Bond at the α-Position of β-Naphthols

5 Construction of Carbon–Carbon and Carbon–Oxygen Bonds at the α-Position of β-Naphthols

6 Construction of Carbon–Halogen Bonds at the α-Position of β-Naphthols

7 Conclusion



Publication History

Received: 15 September 2023

Accepted after revision: 05 October 2023

Article published online:
10 November 2023

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