Synthetic Approaches to Gliflozins: A Comprehensive Overview

Ch. V. A. Sasikala; Pradip D. Nahide; Mallesh Beesu; Sayantan Biswas; Debjit Basu; Srinivas Achanta; Ratnamala Annapragada; Rakeshwar Bandichhor

doi:10.1055/s-0042-1751524

Synthesis, Table of Contents

Synthesis 2024; 56(06): 906-943
DOI: 10.1055/s-0042-1751524

review

Emerging Trends in Glycoscience

Synthetic Approaches to Gliflozins: A Comprehensive Overview

Authors

Ch. V. A. Sasikala

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Pradip D. Nahide ∗

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Mallesh Beesu

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Sayantan Biswas

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Debjit Basu

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Srinivas Achanta

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India
Ratnamala Annapragada∗

^bDepartment of Chemistry, GITAM University, Rudraram, Hyderabad, Telangana, 502329, India
Rakeshwar Bandichhor∗

^aAPI R&D, IPDO, Dr. Reddy’s Laboratories Ltd., Bachupally, Hyderabad, Telangana, 500090, India

Abstract

All articles of this category

Abstract

Diabetes mellitus, commonly referred to as diabetes, is a persistent medical condition that contributes to a significant global mortality rate and various associated complications in individuals. To address the needs of those diagnosed with type 2 diabetes, the pharmaceutical market offers a range of antidiabetic medications. Among these options, gliflozins stand out as highly efficacious therapeutic agents for the management of type 2 diabetes. These medications inhibit the function of sodium–glucose linked transporter (SGLT) enzymes in the kidneys, effectively halting the reabsorption of sugar and leading to a reduction in the overall glucose load within the bloodstream. This review aims at providing a comprehensive overview of the various syntheses for each of the gliflozin drugs reported in the literature and also summarizes the synthetic advancements in this area to date.

1 Introduction

2 Synthesis of Gliflozins

2.1 Canagliflozin

2.2 Dapagliflozin

2.3 Ipragliflozin

2.4 Empagliflozin

2.5 Luseogliflozin

2.6 Tofogliflozin

2.7 Ertugliflozin

2.8 Sotagliflozin

2.9 Licogliflozin

2.10 Remogliflozin

2.11 Henagliflozin

2.12 Bexagliflozin

2.13 Janagliflozin

2.14 Velagliflozin

2.15 Sergliflozin Etabonate

2.16 Enavogliflozin

3 Conclusion

Key words

gliflozins - diabetes mellitus - sodium–glucose co-transporters - SGLT1/2 inhibitors - synthetic methodology

Full Text

References

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