Download PDF
CC BY 4.0 · Eur J Dent 2023; 17(03): 924-928
DOI: 10.1055/s-0042-1753454
Brief Report

Active MMP-8 as a Biomarker of Peri-implant Health or Disease

Vithleem Xanthopoulou 
1   Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Ismo Räisänen 
2   Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
,
Timo Sorsa
2   Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
3   Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
,
Dimitra Sakellari
1   Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
› Author Affiliations Funding This research was funded by Finnish Dental Society Apollonia, Finland; Karolinska Institutet, Stockholm, Sweden; Helsinki and Uusimaa Hospital District (HUS) (Grant/Award numbers: Y1014SULE1, Y1014SL018, Y1014SL017, TYH2019319, TYH2018229, TYH2017251, TYH2016251, TYH2022225).
› Further Information
Also available at
   Permissions and Reprints

Abstract

Objectives This study investigated the potential of testing for active matrix metalloproteinase-8 (aMMP-8) by a quantitative point-of-care (PoC), chairside, lateral flow immunotest as a biomarker for the presence or absence of peri-implant diseases.

Materials and Methods Eighty healthy patients with implants were recruited. The samples were collected from peri-implant sulcular fluid and quantitatively analyzed for aMMP-8. Clinical indices, which included probing depth, clinical attachment loss, bleeding on probing, and plaque, were recorded and radiographic assessments were performed.

Statistical Analysis Comparisons of aMMP-8 levels and clinical parameters were analyzed by the Kruskal–Wallis test and the pairwise post hoc Dunn–Bonferroni test. A receiver operating curve analysis was used to analyze the diagnostic ability of aMMP-8 and the correlation between aMMP-8 and probing depth of the sampled site was sought by Spearman's rho and the coefficient of determination (R 2).

Results Statistical analysis revealed statistically significant differences of aMMP-8 levels between the healthy and the mucositis and peri-implantitis groups, and between the mucositis and the peri-implantitis groups. Increasing probing depths of the sampled site and aMMP-8 levels were significantly correlated.

Conclusions These data suggest that the aMMP-8 PoC test can be a beneficial adjunctive tool for early identification and screening of the risk of peri-implant diseases and progression.

Keywords

aMMP-8 - peri-implant health - peri-implant disease


Publication History

Article published online:
05 September 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol 2018; 89 (Suppl. 01) S267-S290
    CrossrefPubMedSearch in Google Scholar
  • 2 Lindhe J, Meyle J. Group D of European Workshop on Periodontology. Peri-implant diseases: consensus report of the Sixth European Workshop on Periodontology. J Clin Periodontol 2008; 35 (8, Suppl): 282-285
    CrossrefPubMedSearch in Google Scholar
  • 3 Rakic M, Galindo-Moreno P, Monje A. et al. How frequent does peri-implantitis occur? A systematic review and meta-analysis. Clin Oral Investig 2018; 22 (04) 1805-1816
    CrossrefPubMedSearch in Google Scholar
  • 4 Berglundh T, Armitage G, Araujo MG. et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018; 89 (Suppl. 01) S313-S318
    CrossrefPubMedSearch in Google Scholar
  • 5 Sanz M, Chapple IL. Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol 2012; 39 (Suppl. 12) 202-206
    CrossrefPubMedSearch in Google Scholar
  • 6 Sanz M, Noguerol B, Sanz-Sanchez I. et al; Steering Committee. European Association for Osseointegration Delphi study on the trends in Implant Dentistry in Europe for the year 2030. Clin Oral Implants Res 2019; 30 (05) 476-486
    CrossrefPubMedSearch in Google Scholar
  • 7 Sorsa T, Gursoy UK, Nwhator S. et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000 2016; 70 (01) 142-163
    CrossrefPubMedSearch in Google Scholar
  • 8 Al-Majid A, Alassiri S, Rathnayake N, Tervahartiala T, Gieselmann DR, Sorsa T. Matrix metalloproteinase-8 as an inflammatory and prevention biomarker in periodontal and peri-implant diseases. Int J Dent 2018; 2018: 7891323
    CrossrefPubMedSearch in Google Scholar
  • 9 Alassy H, Parachuru P, Wolff L. Peri-implantitis diagnosis and prognosis using biomarkers in peri-implant crevicular fluid: a narrative review. Diagnostics (Basel) 2019; 9 (04) 9
    PubMedSearch in Google Scholar
  • 10 Alassiri S, Parnanen P, Rathnayake N. et al. The ability of quantitative, specific, and sensitive point-of-care/chair-side oral fluid immunotests for aMMP-8 to detect periodontal and peri-implant diseases. Dis Markers 2018; 2018: 1306396
    CrossrefPubMedSearch in Google Scholar
  • 11 Rathnayake N, Gieselmann DR, Heikkinen AM, Tervahartiala T, Sorsa T. Salivary diagnostics-point-of-care diagnostics of MMP-8 in dentistry and medicine. Diagnostics (Basel) 2017; 7 (01) 7
    CrossrefPubMedSearch in Google Scholar
  • 12 Arakawa H, Uehara J, Hara ES. et al. Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis. J Prosthodont Res 2012; 56 (04) 249-255
    CrossrefPubMedSearch in Google Scholar
  • 13 Räisänen IT, Sorsa T, van der Schoor GJ. et al. Active matrix metalloproteinase-8 point-of-care (PoC)/chairside mouthrinse test vs. bleeding on probing in diagnosing subclinical periodontitis in adolescents. Diagnostics (Basel) 2019; 9 (01) 9
    PubMedSearch in Google Scholar
  • 14 Sorsa T, Hernández M, Leppilahti J, Munjal S, Netuschil L, Mäntylä P. Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. Oral Dis 2010; 16 (01) 39-45
    CrossrefPubMedSearch in Google Scholar
  • 15 Lähteenmäki H, Umeizudike KA, Heikkinen AM. et al. aMMP-8 point-of-care/chairside oral fluid technology as a rapid, non-invasive tool for periodontitis and peri-implantitis screening in a medical care setting. Diagnostics (Basel) 2020; 10 (08) 10
    Search in Google Scholar
  • 16 Guarnieri R, Zanza A, D'Angelo M. et al. Correlation between peri-implant marginal bone loss progression and peri-implant sulcular fluid levels of metalloproteinase-8. J Pers Med 2022; 12 (01) 12
    CrossrefPubMedSearch in Google Scholar
  • 17 Sorsa T, Bacigalupo J, Könönen M, Pärnänen P, Räisänen IT. Host-modulation therapy and chair-side diagnostics in the treatment of peri-implantitis. Biosensors (Basel) 2020; 10 (05) 10
    PubMedSearch in Google Scholar
  • 18 Leppilahti JM, Hernández-Ríos PA, Gamonal JA. et al. Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis. J Clin Periodontol 2014; 41 (04) 348-356
    CrossrefPubMedSearch in Google Scholar
  • 19 Lähteenmäki H, Tervahartiala T, Räisänen IT. et al. Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis. Clin Exp Dent Res 2022; 8 (02) 485-496
    CrossrefPubMedSearch in Google Scholar
  • 20 Gul SS, Abdulkareem AA, Sha AM, Rawlinson A. diagnostic accuracy of oral fluids biomarker profile to determine the current and future status of periodontal and peri-implant diseases. Diagnostics (Basel) 2020; 10 (10) 10
    Search in Google Scholar