CC BY-NC-ND 4.0 · Revista Chilena de Ortopedia y Traumatología 2024; 65(01): e34-e39
DOI: 10.1055/s-0042-1755609
Reporte de Caso | Case Report

Aneurysmal Bone Cyst of the Atlas: Treatment with Denosumab and Case Report

Article in several languages: español | English
Sebastián Droguett
1   Servicio de Ortopedia y Traumatología, Hospital Base Valdivia, Valdivia, Chile
2   Instituto de Aparato Locomotor y Rehabilitación, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Los Ríos, Chile
,
Jorge Hernández
2   Instituto de Aparato Locomotor y Rehabilitación, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Los Ríos, Chile
,
1   Servicio de Ortopedia y Traumatología, Hospital Base Valdivia, Valdivia, Chile
2   Instituto de Aparato Locomotor y Rehabilitación, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Los Ríos, Chile
› Author Affiliations

Abstract

We present a case of aneurysmal bone cyst (ABC) of infrequent location and aggressive behavior in a 28-year-old male patient, in which surgical resection is controversial due to the risk of iatrogenicity and eventual recurrence. Treatment with denosumab has been recently proposed as an alternative for the management of unresectable or recurrent ABCs; however, the available literature is sparse. We report our experience with one case and analyze the available literature.



Publication History

Received: 30 July 2021

Accepted: 29 June 2022

Article published online:
03 May 2024

© 2024. Sociedad Chilena de Ortopedia y Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • Referencias

  • 1 Rapp TB, Ward JP, Alaia MJ. Aneurysmal bone cyst. J Am Acad Orthop Surg 2012; 20 (04) 233-241
  • 2 Alhumaid I, Abu-Zaid A. Denosumab Therapy in the Management of Aneurysmal Bone Cysts: A Comprehensive Literature Review. Cureus 2019; 11 (01) e3989
  • 3 Patel RS, Dhamne CA, Gopinathan A, Kumar N, Kumar N. Denosumab: a potential treatment option for aneurysmal bone cyst of the atlas. Eur Spine J 2018; 27 (Suppl. 03) 494-500
  • 4 Palmerini E, Ruggieri P, Angelini A. et al. Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results. Tumori 2018; 104 (05) 344-351
  • 5 Grahneis F, Klein A, Baur-Melnyk A. et al. Aneurysmal bone cyst: A review of 65 patients. J Bone Oncol 2019; 18: 100255
  • 6 Dürr HR, Grahneis F, Baur-Melnyk A. et al. Aneurysmal bone cyst: results of an off label treatment with Denosumab. BMC Musculoskelet Disord 2019; 20 (01) 456
  • 7 Kurucu N, Akyuz C, Ergen FB. et al. Denosumab treatment in aneurysmal bone cyst: Evaluation of nine cases. Pediatr Blood Cancer 2018; 65 (04) DOI: 10.1002/pbc.26926.
  • 8 Pittman K, Antill YC, Goldrick A, Goh J, de Boer RH. Denosumab: Prevention and management of hypocalcemia, osteonecrosis of the jaw and atypical fractures. Asia Pac J Clin Oncol 2017; 13 (04) 266-276
  • 9 Skubitz KM, Peltola JC, Santos ER, Cheng EY. Response of Aneurysmal Bone Cyst to Denosumab. Spine 2015; 40 (22) E1201-E1204
  • 10 Kulkarni AG, Patel A. Denosumab: A potential new treatment option for recurrent Aneurysmal Bone Cyst of the spine. SICOT J 2019; 5: 10