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DOI: 10.1055/s-0042-1756503
Identifying Trends and Quantifying Growth for Technological Innovation in Knee Arthroplasty: An Analysis of a Patent Database (1990 to 2020)
Funding None.Abstract
Technological innovation is the key for surgical progress in knee arthroplasty and improvement in patient outcomes. Exploring patented technologies can help elucidate trends and growth for numerous innovative technologies. However, patent databases, which contain millions of patents, remain underused in arthroplasty research. Therefore, the present study aimed to: (1) quantify patent activity; (2) group patents related to similar technologies into well-defined clusters; and (3) compare growth between technologies in the field of knee arthroplasty over a 30-year period. An open-source international patent database was queried from January 1990 to January 2020 for all patents related to knee arthroplasty A search strategy identified 70,154 patents, of which 24,425 were unique and included analysis. Patents were grouped into 14 independent technology clusters using Cooperative Patent Classification (CPC) codes. Patent activity was normalized via a validated formula adjusting for exponential growth. Compound annual growth rates (CAGR) were calculated (5-year, 10-year, and 30-year CAGR) and compared for each cluster. Overall yearly patent activity increased by 2,023%, from 104 patents in 1990 to 2,208 patents in 2020. The largest technology clusters were “drugs” (n = 5,347; 23.8%), “components” (n = 4,343; 19.0%), “instruments” (n = 3,130; 13.7%), and “materials” (n = 2,378; 10.4%). The fastest growing technologies with their 5-year CAGR were: “user interfaces for surgical systems” (58.1%); “robotics” (28.6%); “modularity” (21.1%); “navigation” (15.7%); and “computer modeling” (12.5%). Since 1990, overall patent growth rate has been greatest for “computer modeling” (8.4%), “robotics” (8.0%), “navigation” (7.9%), and “patient-specific instrumentation” (6.4%). Most patents in knee arthroplasty for the last 30 years have focused on drugs, components, instruments, and materials. Recent exponential growth was mainly observed for user interfaces for surgical systems, robotics, modularity, navigation, and computer-assisted technologies. Innovation theory would suggest that these rapidly growing technologies are experiencing high innovation output, increased resource investments, growing adoption by providers, and significant clinical impact. Periodic monitoring of technological innovation via patent databases can be useful to establish trends and future directions in the field of knee arthroplasty.
Keywords
technological innovation - patents - knee arthroplasty - knee - orthopaedics - research - technologyPublication History
Received: 04 June 2022
Accepted: 26 July 2022
Article published online:
22 September 2022
© 2022. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
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References
- 1 Baig MN, Kearns SR, Shannon FJ, Devitt A. Ten inventions that shaped modern orthopedics. Cureus 2021; 13 (01) e12819
- 2 Sloan M, Premkumar A, Sheth NP. Projected volume of primary total joint arthroplasty in the U.S., 2014 to 2030. J Bone Joint Surg Am 2018; 100 (17) 1455-1460
- 3 Batailler C, Parratte S. Assistive technologies in knee arthroplasty: fashion or evolution? Rate of publications and national registries prove the Scott Parabola wrong. Arch Orthop Trauma Surg 2021; 141 (12) 2027-2034
- 4 Noble PC, Conditt MA, Cook KF, Mathis KB. The John Insall Award: patient expectations affect satisfaction with total knee arthroplasty. Clin Orthop Relat Res 2006; 452 (452) 35-43
- 5 Choi Y-J, Ra HJ. Patient satisfaction after total knee arthroplasty. Knee Surg Relat Res 2016; 28 (01) 1-15
- 6 Kahlenberg CA, Nwachukwu BU, McLawhorn AS, Cross MB, Cornell CN, Padgett DE. patient satisfaction after total knee replacement: a systematic review. HSS J 2018; 14 (02) 192-201
- 7 Gunaratne R, Pratt DN, Banda J, Fick DP, Khan RJK, Robertson BW. Patient dissatisfaction following total knee arthroplasty: a systematic review of the literature. J Arthroplasty 2017; 32 (12) 3854-3860
- 8 Keeney JA. Innovations in total knee arthroplasty: improved technical precision, but unclear clinical benefits. Orthopedics 2016; 39 (04) 217-220
- 9 Siddiqi A, Horan T, Molloy RMRM, Bloomfield MRMR, Patel PDPD, Piuzzi NSNS. A clinical review of robotic navigation in total knee arthroplasty: historical systems to modern design. EFORT Open Rev 2021; 6 (04) 252-269
- 10 Haglin JM, Eltorai AEM, Gil JA, Marcaccio SE, Botero-Hincapie J, Daniels AH. Patient-specific orthopaedic implants. Orthop Surg 2016; 8 (04) 417-424
- 11 Brinkmann EJ, Fitz W. Custom total knee: understanding the indication and process. Arch Orthop Trauma Surg 2021; 141 (12) 2205-2216
- 12 Picard F, Deep K, Jenny JY. Current state of the art in total knee arthroplasty computer navigation. Knee Surg Sports Traumatol Arthrosc 2016; 24 (11) 3565-3574
- 13 Siddiqi A, Smith T, McPhilemy JJ, Ranawat AS, Sculco PK, Chen AF. Soft-tissue balancing technology for total knee arthroplasty. JBJS Rev 2020; 8 (01) e0050-e0050
- 14 Picard F, Deakin AH, Riches PE, Deep K, Baines J. Computer assisted orthopaedic surgery: past, present and future. Med Eng Phys 2019; 72: 55-65
- 15 Riskin DJ, Longaker MT, Gertner M, Krummel TM. Innovation in surgery: a historical perspective. Ann Surg 2006; 244 (05) 686-693
- 16 Hughes-Hallett A, Mayer EK, Marcus HJ. et al. Quantifying innovation in surgery. Ann Surg 2014; 260 (02) 205-211
- 17 Glossary USPTO. . Published 2022. Accessed January 17, 2022 at: https://www.uspto.gov/learning-and-resources/glossary
- 18 Hughes-Hallett A, Mayer EK, Pratt PJ, Vale JA, Darzi AW. Quantitative analysis of technological innovation in minimally invasive surgery. Br J Surg 2015; 102 (02) e151-e157
- 19 Bhatt NR, Davis NF, Dalton DM. et al. Quantitative analysis of technological innovation in urology. Urology 2018; 111: 230-237
- 20 Marcus HJ, Hughes-Hallett A, Kwasnicki RM, Darzi A, Yang G-Z, Nandi D. Technological innovation in neurosurgery: a quantitative study. J Neurosurg 2015; 123 (01) 174-181
- 21 Dalton DM, Burke TP, Kelly EG, Curtin PD. Quantitative analysis of technological innovation in knee arthroplasty: using patent and publication metrics to identify developments and trends. J Arthroplasty 2016; 31 (06) 1366-1372
- 22 Bonutti PM, Seyler TM, Bianco PD, Ulrich SD, Mont MA. Inventing in orthopaedics: from idea to marketed device. J Bone Joint Surg Am 2008; 90 (06) 1385-1392
- 23 Emara AK, Zhou G, Klika AK. et al. Robotic-arm-assisted knee arthroplasty associated with favorable in-hospital metrics and exponentially rising adoption compared with manual knee arthroplasty. J Am Acad Orthop Surg 2021; 29 (24) e1328-e1342
- 24 Tompkins GS, Sypher KS, Li H-F, Griffin TM, Duwelius PJ. Robotic versus manual total knee arthroplasty in high volume surgeons: a comparison of cost and quality metrics. J Arthroplasty 2022; 37 (8S): S782-S789
- 25 Rajan PV, Khlopas A, Klika A, Molloy R, Krebs V, Piuzzi NS. The cost-effectiveness of robotic-assisted versus manual total knee arthroplasty: a Markov model-based evaluation. J Am Acad Orthop Surg 2022; 30 (04) 168-176
- 26 The Lens - Free & Open Patent and Scholarly Search. 2022 . Published 2022. Accessed March 17 2022, at: https://www.lens.org/
- 27 Patent Classification USPTO. . Published 2022. Accessed March 17, 2022 at: https://www.uspto.gov/patents/search/classification-standards-and-development
- 28 Cooperative Patent Classification USPTO. . Published 2022. Accessed March 17, 2022 at: https://www.uspto.gov/web/offices/pac/mpep/s905.html
- 29 Patent Classification Timeline. . Published 2022. Accessed March 17, 2022 at: https://www.uspto.gov/sites/default/files/documents/Timeline.pdf
- 30 Patent Inspiration Database. . Accessed January 26, 2022, at: https://www.patentinspiration.com/
- 31 Siddiqi A, Mont MA, Krebs VE, Piuzzi NS. Not all robotic-assisted total knee arthroplasty are the same. J Am Acad Orthop Surg 2021; 29 (02) 45-59
- 32 Doan GW, Courtis RP, Wyss JG, Green EW, Clary CW. Image-free robotic-assisted total knee arthroplasty improves implant alignment accuracy: a cadaveric study. J Arthroplasty 2022; 37 (04) 795-801
- 33 Batailler C, Fernandez A, Swan J. et al. MAKO CT-based robotic arm-assisted system is a reliable procedure for total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc 2021; 29 (11) 3585-3598
- 34 Khlopas A, Sodhi N, Sultan AA, Chughtai M, Molloy RM, Mont MA. Robotic arm-assisted total knee arthroplasty. J Arthroplasty 2018; 33 (07) 2002-2006
- 35 Kayani B, Konan S, Ayuob A, Onochie E, Al-Jabri T, Haddad FS. Robotic technology in total knee arthroplasty: a systematic review. EFORT Open Rev 2019; 4 (10) 611-617
- 36 Hamilton DA, Ononuju U, Nowak C, Chen C, Darwiche H. Differences in immediate postoperative outcomes between robotic-assisted TKA and conventional TKA. Arthroplast Today 2021; 8: 57-62
- 37 Martinez WL. Graphical user interfaces. Wiley Interdiscip Rev Comput Stat 2011; 3 (02) 119-133
- 38 Karnuta JM, Luu BC, Roth AL. et al. Artificial intelligence to identify arthroplasty implants from radiographs of the knee. J Arthroplasty 2021; 36 (03) 935-940
- 39 Polce EM, Kunze KN, Dooley MS, Piuzzi NS, Boettner F, Sculco PK. Efficacy and applications of artificial intelligence and machine learning analyses in total joint arthroplasty: a call for improved reporting. J Bone Joint Surg Am 2022; 104 (09) 821-832
- 40 Hadad MJ, Orr MN, Emara AK, Klika AK, Johnson JK, Piuzzi NS. PLAN and AM-PAC “6-Clicks” scores to predict discharge disposition after primary total hip and knee arthroplasty. J Bone Joint Surg Am 2022; 104 (04) 326-335
- 41 Anis HK, Strnad GJ, Klika AK. et al; Cleveland Clinic OME Arthroplasty Group. Developing a personalized outcome prediction tool for knee arthroplasty. Bone Joint J 2020; 102-B (09) 1183-1193
- 42 Girbino KL, Klika AK, Barsoum WK. et al; Cleveland Clinic OME Arthroplasty Group. Understanding the main predictors of length of stay after total hip arthroplasty: patient-related or procedure-related risk factors?. J Arthroplasty 2021; 36 (05) 1663-1670.e4
- 43 Visperas AT, Greene KA, Krebs VE, Klika AK, Piuzzi NS, Higuera-Rueda CA. A web-based interactive patient-provider software platform does not increase patient satisfaction or decrease hospital resource utilization in total knee and hip arthroplasty patients in a single large hospital system. J Arthroplasty 2021; 36 (07) 2290-2296.e1
- 44 King D, Emara AK, Ng MK. et al. Transformation from a traditional model to a virtual model of care in orthopaedic surgery: COVID-19 experience and beyond. Bone Jt Open 2020; 1 (06) 272-280
- 45 Goh GS, Lohre R, Parvizi J, Goel DP. Virtual and augmented reality for surgical training and simulation in knee arthroplasty. Arch Orthop Trauma Surg 2021; 141 (12) 2303-2312
- 46 Alpaugh K, Ast MP, Haas SB. Immersive technologies for total knee arthroplasty surgical education. Arch Orthop Trauma Surg 2021; 141 (12) 2331-2335
- 47 Azar FM. Campbell's Operative Orthopaedics. 14th ed.. Elsevier; 2021
- 48 Sheth NP, Bonadio MB, Demange MK. Bone loss in revision total knee arthroplasty: evaluation and management. J Am Acad Orthop Surg 2017; 25 (05) 348-357
- 49 Carender CN, An Q, Tetreault MW, De A, Brown TS, Bedard NA. Use of cementless metaphyseal fixation in revision total knee arthroplasty in the United States. J Arthroplasty 2022; 37 (03) 554-558
- 50 Siddiqi A, Chen AF, Piuzzi NS, Kelly MA. The use of metaphyseal cones and sleeves in revision total knee arthroplasty. J Am Acad Orthop Surg 2021; 29 (18) e904-e920
- 51 Makhdom AM, Parvizi J. Modular versus nonmodular tibial inserts in total knee arthroplasty: what are the differences?. Ann Transl Med 2017; 5 (10) 225-225
- 52 Lamba C, Denning K, Ouellette E, Kurtz S, Bullock M. An interesting case of osteolysis with accompanying metallosis in a primary total knee arthroplasty. Arthroplast Today 2021; 11: 81-87
- 53 Kendall J, Pelt CE, Yep P, Mullen K, Kagan R. Trends in polyethylene design and manufacturing characteristics for total knee arthroplasty: an analysis from the American Joint Replacement Registry. J Arthroplasty 2022; 37 (04) 659-667