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CC BY 4.0 · Eur J Dent 2023; 17(02): 270-282
DOI: 10.1055/s-0042-1756690
Review Article

Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis

Athanasios Tsimpiris
1   Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
2   Dental Sector, 424 General Military Training Hospital, Thessaloniki, Greece
,
Ioannis Tsolianos
3   Dental School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Andreas Grigoriadis 
2   Dental Sector, 424 General Military Training Hospital, Thessaloniki, Greece
4   Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Ioannis Moschos
5   Department of Nursing, International Hellenic University, Thessaloniki, Greece
,
Dimitrios G. Goulis 
6   1st Department of Obstetrics and Gynecology, Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Georgios Kouklakis
7   A΄ Department of Pathology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
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Abstract

Helicobacter pylori (H. pylori) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I2. Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori, detected either in subgingival plaque and gingival crevicular fluid or in the stomach.

Keywords

chronic periodontitis - Helicobacter pylori - subgingival plaque - stomach - meta-analysis


Publication History

Article published online:
18 November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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