Impact of intraovarian injection of autologous platelet-rich plasma and mature oocyte retrieval in women with reduced ovarian reserve – a systemic review

The clinical treatment of patients with poor ovarian response (POR) or premature ovarian insufficiency (POI) is a major challenge in reproductive medicine. Recent studies on ovarian rejuvenation show that intraovarian injection of autologous platelet-rich plasma (PRP) can restore fertility in women with POI or POR. PRP contains a variety of growth factors, which play an important role in tissue regeneration and healing, and consequently, in intraovarianapplication, promote the reactivation of folliculogenesis, leading to improved development of primary and pre-antral follicles.

A systematic review was performed. PubMed(MEDLINE) databases were searched for studies published between 2013 and 2021. This systematic review was conducted to evaluate the effectiveness of intraovarian PRP application in subfertile women to improve reproductive outcomes after IVF. As primary outcome we defined the number of mature oocytes.

We will perform a meta-analysis, including three prospective and one retrospective study. The aim will be to compare the impact on retrieved and mature oocytes before and after intraovarian PRP treatment on a population of 158 patients. The total number and maturity of the collected oocytes were not modified by the volume of PRP used. All four studies showed a higher number of mature MII oocytes in the performance of the ICSI cycle after intraovarian PRP treatment.

Our systematic review showed that intraovarian infusion of PRP increases the retrieval of mature oocytes. This novel therapy represents an important finding in reproductive medicine, as it has the potential to overcome ovarian reserve deficiency and thus the possibility to obtain a genetically own child.

Publication History

Article published online:
11 October 2022